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AASS Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6270366

This gene encodes a bifunctional enzyme that catalyzes the first two steps in the mammalian lysine degradation pathway. The N-terminal and the C-terminal portions of this enzyme contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity,… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
AASS, Polyclonal Antibody
Full Product Name
AASS, CT (AASS, Alpha-aminoadipic semialdehyde synthase, mitochondrial, LKR/SDH, Lysine ketoglutarate reductase, Saccharopine dehydrogenase) (Biotin)
Product Gene Name
anti-AASS antibody
Product Synonym Names
AASS; Alpha-aminoadipic semialdehyde synthase, mitochondrial; LKR/SDH; Lysine ketoglutarate reductase; Saccharopine dehydrogenase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
102,132 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (121713598..121784344, complement). Location: 7q31.3
OMIM
238700
3D Structure
ModBase 3D Structure for Q9UDR5
Immunogen
AASS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 812-841 amino acids from the C-terminal region of human AASS.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-AASS antibody

Antibodies; Mitochondrial Proteins
Applications Tested/Suitable for anti-AASS antibody
Flow Cytometry (FC/FACS), ELISA (EIA), Western Blot (WB)
Application Notes for anti-AASS antibody
FC/FACS: 1:10-50
ELISA: 1:1,000
WB: 1:50-100
Applications are based on unconjugated antibody.

Product References and Citations for anti-AASS antibody

Sacksteder, K.A., et al. Am. J. Hum. Genet. 66(6):1736-1743(2000). Papes, F., et al. Biochem. J. 344 PT 2, 555-563 (1999).

Other Notes

Small volumes of anti-AASS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AASS purchase

MBS6270366 is an antibody targeting AASS. Also known as AASS, CT (AASS, Alpha-aminoadipic semialdehyde synthase, mitochondrial, LKR/SDH, Lysine ketoglutarate reductase, Saccharopine dehydrogenase) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AASS. It may not necessarily be applicable to this product.

NCBI GI #
13027640
NCBI GeneID
10157
NCBI Accession #
NP_005754.2
UniProt Primary Accession #
Q9UDR5
UniProt Secondary Accession #
O95462
UniProt Related Accession #
Q9UDR5
GenBank Nucleotide #
NM_005763.3
NCBI Official Full Name
alpha-aminoadipic semialdehyde synthase, mitochondrial
NCBI Official Synonym Full Names
aminoadipate-semialdehyde synthase
NCBI Official Symbol
AASS
NCBI Official Synonym Symbols
LKRSDH; LORSDH; LKR/SDH
UniProt Protein Name
Alpha-aminoadipic semialdehyde synthase, mitochondrial
UniProt Synonym Protein Names
LKR/SDH
UniProt Gene Name
AASS
UniProt Synonym Gene Names
LKR; LOR; SDH
UniProt Entry Name
AASS_HUMAN
NCBI Protein Information
alpha-aminoadipic semialdehyde synthase, mitochondrial; lysine-2-oxoglutarate reductase; alpha-aminoadipate semialdehyde synthase; lysine-ketoglutarate reductase /saccharopine dehydrogenase

UniProt Comments for AASS

AASS: Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively. Defects in AASS are the cause of hyperlysinemia (HYPLYS). Hyperlysinemia is an autosomal recessive condition characterized by hyperlysinemia lysinuria and variable saccharopinuria.

Protein type: EC 1.5.1.8; EC 1.5.1.9; Oxidoreductase; Mitochondrial; Amino Acid Metabolism - lysine biosynthesis; Amino Acid Metabolism - lysine degradation

Chromosomal Location of Human Ortholog: 7q31.3

Cellular Component: mitochondrion; intracellular membrane-bound organelle; mitochondrial matrix

Molecular Function: saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity; saccharopine dehydrogenase (NADP+, L-lysine-forming) activity

Biological Process: L-lysine catabolic process to acetyl-CoA via saccharopine; lysine catabolic process; protein tetramerization

Disease: Saccharopinuria; Hyperlysinemia, Type I
Show more

Research Articles on AASS

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-AASS antibody

 Products by Pathway  Pathway Diagram
 Lysine Catabolism Pathway antibodies  Lysine Catabolism Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation, Lysine => Saccharopine => Acetoacetyl-CoA Pathway antibodies  Lysine Degradation, Lysine => Saccharopine => Acetoacetyl-CoA Pathway Diagram
 Lysine Degradation, Lysine => Saccharopine => Acetoacetyl-CoA Pathway antibodies  Lysine Degradation, Lysine => Saccharopine => Acetoacetyl-CoA Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Lysine Degradation II Pathway antibodies  Lysine Degradation II Pathway Diagram
 Lysine Degradation II Pathway antibodies  Lysine Degradation II Pathway Diagram
 Superpathway Of Lysine Degradation antibodies  Superpathway Of Lysine Degradation Diagram

Diseases associated with anti-AASS antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >88 publications with AASS and Neoplasms
 Cardiovascular Diseases Antibodies  >49 publications with AASS and Cardiovascular Diseases
 Heart Diseases Antibodies  >36 publications with AASS and Heart Diseases
 Nervous System Diseases Antibodies  >23 publications with AASS and Nervous System Diseases
 Drug Toxicity Antibodies  >15 publications with AASS and Drug Toxicity
 Necrosis Antibodies  >10 publications with AASS and Necrosis
 Brain Diseases Antibodies  >8 publications with AASS and Brain Diseases
 Lung Diseases Antibodies  >8 publications with AASS and Lung Diseases
 Inflammation Antibodies  >7 publications with AASS and Inflammation
 Hypertrophy Antibodies  >6 publications with AASS and Hypertrophy

Organs/Tissues associated with anti-AASS antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >62 publications with AASS and Heart
 Blood Antibodies  >51 publications with AASS and Blood
 Muscle Antibodies  >48 publications with AASS and Muscle
 Bone Antibodies  >27 publications with AASS and Bone
 Brain Antibodies  >24 publications with AASS and Brain
 Lymph Node Antibodies  >16 publications with AASS and Lymph Node
 Liver Antibodies  >15 publications with AASS and Liver
 Testis Antibodies  >13 publications with AASS and Testis
 Nerve Antibodies  >12 publications with AASS and Nerve
 Lung Antibodies  >12 publications with AASS and Lung
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