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ABCB7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6460817

MBS6460817 is an antibody targeting ABCB7. Also known as ABCB7, CT (ATP-binding Cassette Sub-family B Member 7, Mitochondrial, ATP-binding Cassette Transporter 7, ABC Transporter 7 Protein, ABC7) (Biotin). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ABCB7, Polyclonal Antibody
Full Product Name
ABCB7, CT (ATP-binding Cassette Sub-family B Member 7, Mitochondrial, ATP-binding Cassette Transporter 7, ABC Transporter 7 Protein, ABC7) (Biotin)
Product Gene Name
anti-ABCB7 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A/G Affinity Chromatography.
Specificity
Recognizes human ABCB7.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
78,160 Da
OMIM
300135
3D Structure
ModBase 3D Structure for O75027
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 718-746 in the C-terminal region of human ABCB7, UniProt Accession #O75027. Species sequence homology: mouse and rat
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-ABCB7 antibody

Antibodies; Multi Drug Resistance (MDR)
Applications Tested/Suitable for anti-ABCB7 antibody
Immunohistochemistry (IHC) Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-ABCB7 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ABCB7 antibody

Western Blot to detect ABCB7 in Jurkat cell lysate usingMBS626330.
Rabbit Anti-ABCB7 Polyclonal Antibody – Cat# MBS6460817

Immunohistochemistry (IHC) of anti-ABCB7 antibody

Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human cancer tissue reacted withMBS626330, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates that MBS626330 for immunohistochemistry. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-ABCB7 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6460817

Product References and Citations for anti-ABCB7 antibody

1. Allikmets, R., et al., Hum. Mol. Genet. 8(5):743-749 (1999). 2. Csere, P., et al., FEBS Lett. 441(2):266-270 (1998). 3. Mao, M., et al., Proc. Natl. Acad. Sci. USA 95(14):8175-8180 (1998). 4. Shimada, Y., et al., J. Hum. Genet. 43(2):115-122 (1998). 5. Savary, S., et al., Genomics 41(2):275-278 (1997).

Other Notes

Small volumes of anti-ABCB7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ABCB7. It may not necessarily be applicable to this product.

NCBI GI #
42490749
NCBI GeneID
22
NCBI Accession #
NP_004290
UniProt Primary Accession #
O75027
UniProt Secondary Accession #
O75345; Q5VWY7; Q5VWY8; Q9BRE1; Q9UND1; Q9UP01; G3XAC4
UniProt Related Accession #
O75027
GenBank Nucleotide #
NM_004299
NCBI Official Full Name
ATP-binding cassette sub-family B member 7, mitochondrial isoform 1
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family B (MDR/TAP), member 7
NCBI Official Symbol
ABCB7
NCBI Official Synonym Symbols
ABC7; ASAT; Atm1p; EST140535
UniProt Protein Name
ATP-binding cassette sub-family B member 7, mitochondrial
UniProt Synonym Protein Names
ATP-binding cassette transporter 7
Protein Family
ABC transporter B family
UniProt Gene Name
ABCB7
UniProt Synonym Gene Names
ABC7; ABC transporter 7 protein
UniProt Entry Name
ABCB7_HUMAN
NCBI Protein Information
ATP-binding cassette sub-family B member 7, mitochondrial; ABC transporter 7 protein; ATP-binding cassette transporter 7

UniProt Comments for ABCB7

ABCB7: Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. Defects in ABCB7 are the cause of X-linked sideroblastic anemia with ataxia (ASAT). ASAT is a recessive disorder characterized by an infantile to early childhood onset of nonprogressive cerebellar ataxia and mild anemia with hypochromia and microcytosis. Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter; Transporter, ABC family; Membrane protein, multi-pass; Membrane protein, integral; Mitochondrial

Chromosomal Location of Human Ortholog: Xq13.3

Cellular Component: mitochondrion; mitochondrial inner membrane; integral to membrane

Molecular Function: ATPase activity, coupled to transmembrane movement of substances; heme transporter activity; ATP binding

Biological Process: heme transport; transport; cellular iron ion homeostasis; transmembrane transport

Disease: Anemia, Sideroblastic, And Spinocerebellar Ataxia
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ABCB7 antibody

 Reference Product  PubMed Publications
 PGK1 antibody  >1 publications with ABCB7 and PGK1
 FECH antibody  >1 publications with ABCB7 and FECH

Pathways associated with anti-ABCB7 antibody

 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Cytosolic Iron-sulfur Cluster Assembly Pathway antibodies  Cytosolic Iron-sulfur Cluster Assembly Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Mitochondrial ABC Transporters Pathway antibodies  Mitochondrial ABC Transporters Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-ABCB7 antibody

 Disease Name  Pubmed Publications
 Anemia Antibodies  >36 publications with ABCB7 and Anemia
 Anemia, Sideroblastic Antibodies  >31 publications with ABCB7 and Anemia, Sideroblastic
 Ataxia Antibodies  >21 publications with ABCB7 and Ataxia
 Nervous System Diseases Antibodies  >11 publications with ABCB7 and Nervous System Diseases
 Anemia, sideroblastic spinocerebellar ataxia Antibodies  >4 publications with ABCB7 and Anemia, sideroblastic spinocerebellar ataxia
 Liver Diseases Antibodies  >1 publications with ABCB7 and Liver Diseases
 Fatty Liver Antibodies  >1 publications with ABCB7 and Fatty Liver
 Cell Transformation, Neoplastic Antibodies  >1 publications with ABCB7 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-ABCB7 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >17 publications with ABCB7 and Blood
 Bone Antibodies  >12 publications with ABCB7 and Bone
 Bone Marrow Antibodies  >12 publications with ABCB7 and Bone Marrow
 Liver Antibodies  >5 publications with ABCB7 and Liver
 Brain Antibodies  >2 publications with ABCB7 and Brain
 Skin Antibodies  >1 publications with ABCB7 and Skin
 Embryonic Tissue Antibodies  >1 publications with ABCB7 and Embryonic Tissue
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