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ABCG1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6460864

MBS6460864 is an antibody targeting ABCG1. Also known as ABCG1, NT (ATP-binding Cassette Sub-family G Member 1, ATP-binding Cassette Transporter 8, White Protein Homolog, WHT1, ABC8) (MaxLight 405). Reactive in Human. Host: Rabbit. More details

$1025 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ABCG1, Polyclonal Antibody
Full Product Name
ABCG1, NT (ATP-binding Cassette Sub-family G Member 1, ATP-binding Cassette Transporter 8, White Protein Homolog, WHT1, ABC8) (MaxLight 405)
Product Gene Name
anti-ABCG1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human ABCG1.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
86,628 Da
OMIM
603076
3D Structure
ModBase 3D Structure for P45844
Immunogen
Synthetic peptide selected from the center region of human ABCG1 (KLH).
Conjugate
MaxLight405
Note
Preservative Free

Product Categories/Family for anti-ABCG1 antibody

Antibodies; Multi Drug Resistance (MDR)
Applications Tested/Suitable for anti-ABCG1 antibody
Western Blot (WB), FLISA
Application Notes for anti-ABCG1 antibody
WB: 1:50-1:100
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ABCG1 antibody

Western blot analysis of ABCG1 Antibody (Center) in 293 cell line lysates (35ug/lane). ABCG1 (arrow) was detected using the purified Pab.
Rabbit Anti-ABCG1 Polyclonal Antibody – Cat# MBS6460864

Immunohistochemistry (IHC) of anti-ABCG1 antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with ABCG1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-ABCG1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6460864

Flow Cytometry (FC/FACS) of anti-ABCG1 antibody

ABCG1 Antibody (Center) flow cytometry analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-ABCG1 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6460864

Product References and Citations for anti-ABCG1 antibody

1. Furuyama, S., J. Atheroscler. Thromb. 16(3), 194-200 (2009). 2. Stefulj, J., Circ. Res. 104(5), 600-608 (2009). 3. Mauerer, R., Exp. Mol. Med. 41(2), 126-132 (2009).

Other Notes

Small volumes of anti-ABCG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ABCG1. It may not necessarily be applicable to this product.

NCBI GI #
46592915
NCBI GeneID
9619
NCBI Accession #
NP_004906
UniProt Primary Accession #
P45844
UniProt Secondary Accession #
Q86SU8; Q96L76; Q9BXK6; Q9BXK7; Q9BXK8; Q9BXK9; Q9BXL0; Q9BXL1; Q9BXL2; Q9BXL3; Q9BXL4
UniProt Related Accession #
P45844
GenBank Nucleotide #
NM_004915
NCBI Official Full Name
ATP-binding cassette sub-family G member 1 isoform 4
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family G (WHITE), member 1
NCBI Official Symbol
ABCG1
NCBI Official Synonym Symbols
ABC8; WHITE1
UniProt Protein Name
ATP-binding cassette sub-family G member 1
UniProt Synonym Protein Names
ATP-binding cassette transporter 8; White protein homolog
Protein Family
ABC transporter G family
UniProt Gene Name
ABCG1
UniProt Synonym Gene Names
ABC8; WHT1
UniProt Entry Name
ABCG1_HUMAN
NCBI Protein Information
ATP-binding cassette sub-family G member 1; ABC transporter 8; ATP-binding cassette transporter 8; ATP-binding cassette transporter member 1 of subfamily G; homolog of Drosophila white; white protein homolog (ATP-binding cassette transporter 8)

UniProt Comments for ABCG1

ABCG1: Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, ABC family; Transporter

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: Golgi membrane; nucleoplasm; Golgi apparatus; endoplasmic reticulum membrane; recycling endosome; mitochondrion; intracellular membrane-bound organelle; integral to plasma membrane; plasma membrane; endosome; external side of plasma membrane

Molecular Function: protein dimerization activity; protein binding; protein homodimerization activity; phospholipid transporter activity; protein heterodimerization activity; cholesterol transporter activity; cholesterol binding; toxin transporter activity; phospholipid binding; sterol-transporting ATPase activity; ADP binding; ATP binding

Biological Process: cholesterol metabolic process; detection of hormone stimulus; response to high density lipoprotein stimulus; positive regulation of cholesterol biosynthetic process; lipoprotein metabolic process; intracellular cholesterol transport; cholesterol efflux; response to lipid; response to organic substance; cholesterol homeostasis; amyloid precursor protein catabolic process; reverse cholesterol transport; regulation of transcription, DNA-dependent; phospholipid efflux; transmembrane transport; phospholipid homeostasis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ABCG1 antibody

 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 ABCA Transporters In Lipid Homeostasis Pathway antibodies  ABCA Transporters In Lipid Homeostasis Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
 Lipoprotein Metabolism Pathway antibodies  Lipoprotein Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram

Diseases associated with anti-ABCG1 antibody

 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >302 publications with ABCG1 and Atherosclerosis
 Cardiovascular Diseases Antibodies  >208 publications with ABCG1 and Cardiovascular Diseases
 Inflammation Antibodies  >102 publications with ABCG1 and Inflammation
 Dyslipidemias Antibodies  >55 publications with ABCG1 and Dyslipidemias
 Liver Diseases Antibodies  >53 publications with ABCG1 and Liver Diseases
 Fatty Liver Antibodies  >47 publications with ABCG1 and Fatty Liver
 Hyperlipidemias Antibodies  >36 publications with ABCG1 and Hyperlipidemias
 Hypercholesterolemia Antibodies  >33 publications with ABCG1 and Hypercholesterolemia
 Necrosis Antibodies  >31 publications with ABCG1 and Necrosis
 Nervous System Diseases Antibodies  >30 publications with ABCG1 and Nervous System Diseases

Organs/Tissues associated with anti-ABCG1 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >323 publications with ABCG1 and Liver
 Blood Antibodies  >214 publications with ABCG1 and Blood
 Brain Antibodies  >56 publications with ABCG1 and Brain
 Lung Antibodies  >37 publications with ABCG1 and Lung
 Muscle Antibodies  >36 publications with ABCG1 and Muscle
 Intestine Antibodies  >22 publications with ABCG1 and Intestine
 Kidney Antibodies  >22 publications with ABCG1 and Kidney
 Pancreas Antibodies  >12 publications with ABCG1 and Pancreas
 Connective Tissue Antibodies  >12 publications with ABCG1 and Connective Tissue
 Spleen Antibodies  >12 publications with ABCG1 and Spleen
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