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ABCG2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9601350

Function: High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to… More details

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Product Overview

Online Datasheet in PDF
Product Name
ABCG2, Polyclonal Antibody
Full Product Name
ABCG2 Antibody
Product Gene Name
anti-ABCG2 antibody
Product Synonym Names
ABC transporter; ABC15; ABCG 2; ABCG2; ABCG2_HUMAN; ABCP; ATP binding cassette sub family G (WHITE) member 2; ATP binding cassette transporter G2; ATP-binding cassette sub-family G member 2; BCRP; BCRP1; BMDP; Breast cancer resistance protein; CD338; CDw338; CDw338 antigen; EST157481; GOUT1; MGC102821; Mitoxantrone resistance associated protein; Mitoxantrone resistance-associated protein; MRX; Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2; MXR; MXR1; Placenta specific ATP binding cassette transporter; Placenta specific MDR protein; Placenta-specific ATP-binding cassette transporter; UAQTL1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
ABCG2 antibody detects endogenous levels of total ABCG2
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
ABCG2 peptide (MBS9616882) is used for blocking the activity of ABCG2 antibody (MBS9601350)
Molecular Weight
Observed: 72 kDa
Predicted: 73 kDa
3D Structure
ModBase 3D Structure for Q9UNQ0
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human ABCG2
Subcellular Location
Cell Membrane
Tissue Specificity
Highly expressed in placenta. Low expression in small intestine, liver and colon.
Predicted Cross Reactivity
Rabbit
Similarity
Rabbit (89%)
Conjugation
Unconjugated
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ABCG2 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-ABCG2 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200

Immunohistochemistry (IHC) of anti-ABCG2 antibody

MBS9601350 at 1/100 staining human brain tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Rabbit Anti-ABCG2 Polyclonal Antibody – Cat# MBS9601350

Western Blot (WB) of anti-ABCG2 antibody

Western blot analysis of ABCG2 expression in HT-29 cells, The lane on the left is treated with the antigen-specific peptide.
Rabbit Anti-ABCG2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9601350

Other Notes

Small volumes of anti-ABCG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ABCG2 purchase

MBS9601350 is an antibody targeting ABCG2. Also known as ABCG2 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ABCG2. It may not necessarily be applicable to this product.

NCBI GI #
383792176
NCBI GeneID
9429
NCBI Accession #
NP_001244315.1
UniProt Primary Accession #
Q9UNQ0
UniProt Secondary Accession #
O95374; Q4W5I3; Q53ZQ1; Q569L4; Q5YLG4; Q86V64; Q8IX16; Q96LD6; Q96TA8; A0A1W3; A8K1T5
UniProt Related Accession #
Q9UNQ0
GenBank Nucleotide #
NM_001257386.2
NCBI Official Full Name
ATP-binding cassette sub-family G member 2 isoform 2
NCBI Official Synonym Full Names
ATP binding cassette subfamily G member 2 (Junior blood group)
NCBI Official Symbol
ABCG2
NCBI Official Synonym Symbols
MRX; MXR; ABCP; BCRP; BMDP; MXR1; ABC15; BCRP1; CD338; GOUT1; MXR-1; CDw338; UAQTL1; EST157481
UniProt Protein Name
ATP-binding cassette sub-family G member 2
UniProt Synonym Protein Names
Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; Urate exporter; CD_antigen: CD338
Protein Family
ABC transporter G family
UniProt Gene Name
ABCG2
UniProt Synonym Gene Names
ABCP; BCRP; BCRP1; MXR
NCBI Protein Information
ATP-binding cassette sub-family G member 2

NCBI Summary for ABCG2

The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
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UniProt Comments for ABCG2

High-capacity urate exporter functioning in both renal and extrarenal urate excretion. Plays a role in porphyrin homeostasis as it is able to mediates the export of protoporhyrin IX (PPIX) both from mitochondria to cytosol and from cytosol to extracellular space, and cellular export of hemin, and heme. Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. Implicated in the efflux of numerous drugs and xenobiotics: mitoxantrone, the photosensitizer pheophorbide, camptothecin, methotrexate, azidothymidine (AZT), and the anthracyclines daunorubicin and doxorubicin.
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Research Articles on ABCG2

1. 13-cis-retinoic acid, retinol and retinyl-acetate inhibited the Pgp and ABCG2 mediated substrate transport as well as the substrate stimulated ATPase activity of these transporters.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ABCG2 antibody

 Reference Product  PubMed Publications
 ABCC1 antibody  >317 publications with ABCG2 and ABCC1
 ABCC2 antibody  >263 publications with ABCG2 and ABCC2
 SLC22A1 antibody  >23 publications with ABCG2 and SLC22A1
 PTEN antibody  >22 publications with ABCG2 and PTEN
 HIF1A antibody  >11 publications with ABCG2 and HIF1A
 ABL1 antibody  >5 publications with ABCG2 and ABL1
 SLC22A2 antibody  >5 publications with ABCG2 and SLC22A2
 ARNT antibody  >3 publications with ABCG2 and ARNT
 SLC22A3 antibody  >1 publications with ABCG2 and SLC22A3

Pathways associated with anti-ABCG2 antibody

 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 Abacavir Transmembrane Transport Pathway antibodies  Abacavir Transmembrane Transport Pathway Diagram
 Abacavir Transport And Metabolism Pathway antibodies  Abacavir Transport And Metabolism Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Fluoropyrimidine Activity Pathway antibodies  Fluoropyrimidine Activity Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 HIF-2-alpha Transcription Factor Network Pathway antibodies  HIF-2-alpha Transcription Factor Network Pathway Diagram
 Irinotecan Pathway antibodies  Irinotecan Pathway Diagram

Diseases associated with anti-ABCG2 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >462 publications with ABCG2 and Breast Neoplasms
 Lung Neoplasms Antibodies  >159 publications with ABCG2 and Lung Neoplasms
 Nervous System Diseases Antibodies  >128 publications with ABCG2 and Nervous System Diseases
 Brain Diseases Antibodies  >113 publications with ABCG2 and Brain Diseases
 Liver Diseases Antibodies  >101 publications with ABCG2 and Liver Diseases
 Colorectal Neoplasms Antibodies  >94 publications with ABCG2 and Colorectal Neoplasms
 Liver Neoplasms Antibodies  >89 publications with ABCG2 and Liver Neoplasms
 Disease Models, Animal Antibodies  >76 publications with ABCG2 and Disease Models, Animal
 Inflammation Antibodies  >68 publications with ABCG2 and Inflammation
 Cardiovascular Diseases Antibodies  >65 publications with ABCG2 and Cardiovascular Diseases

Organs/Tissues associated with anti-ABCG2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >447 publications with ABCG2 and Brain
 Liver Antibodies  >346 publications with ABCG2 and Liver
 Kidney Antibodies  >282 publications with ABCG2 and Kidney
 Lung Antibodies  >253 publications with ABCG2 and Lung
 Intestine Antibodies  >202 publications with ABCG2 and Intestine
 Placenta Antibodies  >130 publications with ABCG2 and Placenta
 Embryonic Tissue Antibodies  >127 publications with ABCG2 and Embryonic Tissue
 Vascular Antibodies  >124 publications with ABCG2 and Vascular
 Muscle Antibodies  >68 publications with ABCG2 and Muscle
 Prostate Antibodies  >61 publications with ABCG2 and Prostate
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