• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

ABRAXAS Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3902604

Abraxas was identified in a phosphopeptide affinity proteomic and mass spec analysis as a protein that bound directly to the BRCA1 BRCT repeat. Along with RAP80, Abraxas was required to form a complex with BRCA1 for the DNA damage response. More details

$250 / 0.01 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Abraxas, Polyclonal Antibody
Full Product Name
Rabbit anti-Abraxas Antibody, Affinity Purified
Product Gene Name
anti-Abraxas antibody
Product Synonym Gene Name
ABRAXAS1
Product Synonym Names
coiled-coil domain containing 98; family with sequence similarity 175 member A; Protein FAM175A; FAM175A; Coiled-coil domain-containing protein 98; CCDC98; BRCA1-A complex subunit Abraxas 1; BRCA1-A complex subunit Abraxas; ABRA1; abraxas protein; BRCA1-A complex subunit Abraxas; abraxas 1, BRCA1 A complex subunit
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Whole IgG. Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Purity/Purification
Antigen Affinity Purified
Concentration
1000ug/ml (lot specific)
Preparation and Storage
Store at 2-8 degree C
Shelf Life: 1 year from date of receipt
Molecular Weight
46,663 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (84382092..84406290, complement). Location: 4q21.23
OMIM
phenotype 611143
3D Structure
ModBase 3D Structure for Q6UWZ7
Immunogen
Between 359 and C-terminus
Conjugation
Unconjugated

Product Categories/Family for anti-Abraxas antibody

Primary Antibodies
Applications Tested/Suitable for anti-Abraxas antibody
Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-Abraxas antibody
IP: 6ug/mg lysate
IHC: 1:500-1:2000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Immunohistochemistry (IHC) of anti-Abraxas antibody

Detection of human Abraxas by immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-Abraxas (Cat. No. MBS3902604) used at a dilution of 1:1,000 (1ug/ml). Detection: DAB
Rabbit Anti-ABRAXAS Polyclonal Antibody – Cat# MBS3902604

Immunoprecipitation (IP) of anti-Abraxas antibody

Detection of human Abraxas by western blot of immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-Abraxas antibody MBS3902604 used for IP at 10 ug/mg lysate. Abraxas was also immunoprecipitated by rabbit anti-Abraxas antibody MBS3902603, which recognizes an upstream epitope. For blotting immunoprecipitated Abraxas, MBS3902603 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.
Rabbit Anti-ABRAXAS Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS3902604

Other Notes

Small volumes of anti-Abraxas antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Abraxas purchase

MBS3902604 is an antibody targeting Abraxas. Also known as Rabbit anti-Abraxas Antibody, Affinity Purified. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Abraxas. It may not necessarily be applicable to this product.

NCBI GI #
109148531
NCBI GeneID
84142
NCBI Accession #
NP_620775.2
UniProt Primary Accession #
Q6UWZ7
UniProt Secondary Accession #
Q9H8I1; Q9H9N4; A5JJ07
UniProt Related Accession #
Q6UWZ7
GenBank Nucleotide #
NM_139076.2
NCBI Official Full Name
BRCA1-A complex subunit Abraxas
NCBI Official Synonym Full Names
family with sequence similarity 175, member A
NCBI Official Symbol
FAM175A
NCBI Official Synonym Symbols
ABRA1; CCDC98
UniProt Protein Name
BRCA1-A complex subunit Abraxas
UniProt Synonym Protein Names
Coiled-coil domain-containing protein 98; Protein FAM175A
Protein Family
BRCA1-A complex
UniProt Gene Name
FAM175A
UniProt Synonym Gene Names
ABRA1; CCDC98
UniProt Entry Name
F175A_HUMAN
NCBI Protein Information
BRCA1-A complex subunit Abraxas; abraxas protein; coiled-coil domain containing 98; coiled-coil domain-containing protein 98

UniProt Comments for Abraxas

Abraxas: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1. Belongs to the FAM175 family. Abraxas subfamily.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 4q21.23

Cellular Component: nucleus

Molecular Function: protein binding; polyubiquitin binding

Biological Process: positive regulation of DNA repair; double-strand break repair; chromatin modification; response to ionizing radiation; G2/M transition DNA damage checkpoint
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Abraxas antibody

 Reference Product  PubMed Publications
 BRCA1 antibody  >23 publications with Abraxas and BRCA1
 BRCC3 antibody  >6 publications with Abraxas and BRCC3
 BRE antibody  >4 publications with Abraxas and BRE
 BARD1 antibody  >3 publications with Abraxas and BARD1
 ATM antibody  >2 publications with Abraxas and ATM
 MRE11A antibody  >2 publications with Abraxas and MRE11A
 RAD50 antibody  >1 publications with Abraxas and RAD50
 UIMC1 antibody  >1 publications with Abraxas and UIMC1

Diseases associated with anti-Abraxas antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >7 publications with Abraxas and Breast Neoplasms
 Ovarian Neoplasms Antibodies  >5 publications with Abraxas and Ovarian Neoplasms

Organs/Tissues associated with anti-Abraxas antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >2 publications with Abraxas and Lung
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000