Rabbit Anti-ACACA Polyclonal Antibody – Cat# MBS6270751

ACACA Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the ACACA antibody detected the ACACA protein (arrow).

ACACA Antibody – Rabbit Polyclonal

Name: ACACA Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6270751
Price: 1120 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6270751

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta,… More details

$1120 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ACACA, Polyclonal Antibody

Full Product Name

ACACA, CT (ACACA, ACAC, ACC1, ACCA, Acetyl-CoA carboxylase 1, ACC-alpha, Biotin carboxylase) (Biotin)

Product Gene Name

anti-ACACA antibody

Product Synonym Names

ACACA; ACAC; ACC1; ACCA; Acetyl-CoA carboxylase 1; ACC-alpha; Biotin carboxylase

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

259,686 Da

OMIM

200350

3D Structure

ModBase 3D Structure for Q13085

Immunogen

ACACA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2009-2039 amino acids from the C-terminal region of human ACACA.

Conjugate

Biotin

Note

Preservative Free

Product Categories/Family for anti-ACACA antibody

Antibodies; Enzymes

Applications Tested/Suitable for anti-ACACA antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-ACACA antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-ACACA antibody

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Kim, C.W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(21):9626-9631(2010). Zhao, L.F., et al. Endocr. J. 57(4):317-324(2010).

Other Notes

Small volumes of anti-ACACA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACACA purchase

MBS6270751 is an antibody targeting ACACA. Also known as ACACA, CT (ACACA, ACAC, ACC1, ACCA, Acetyl-CoA carboxylase 1, ACC-alpha, Biotin carboxylase) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ACACA. It may not necessarily be applicable to this product.

NCBI GI #

38679967

NCBI GeneID

NCBI Accession #

NP_942133.1

NCBI Related Accession #

NP_942131.1

UniProt Primary Accession #

Q13085

UniProt Secondary Accession #

Q6KEV6; Q6XDA8; Q7Z2G8; Q7Z561; Q7Z563; Q7Z564; Q86WB2; Q86WB3; B2RP68

UniProt Related Accession #

Q13085

GenBank Nucleotide #

NM_198836.2

NCBI Official Full Name

acetyl-CoA carboxylase 1 isoform 2

NCBI Official Synonym Full Names

acetyl-CoA carboxylase alpha

NCBI Official Symbol

ACACA

NCBI Official Synonym Symbols

ACC; ACAC; ACC1; ACCA; ACACAD

UniProt Protein Name

Acetyl-CoA carboxylase 1

UniProt Synonym Protein Names

ACC-alpha

UniProt Gene Name

ACACA

UniProt Synonym Gene Names

ACAC; ACC1; ACCA; ACC1

UniProt Entry Name

ACACA_HUMAN

NCBI Protein Information

acetyl-CoA carboxylase 1

UniProt Comments for ACACA

ACC1: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity.

Protein type: Ligase; EC 6.3.4.14; EC 6.4.1.2; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; Lipid Metabolism - fatty acid biosynthesis

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: mitochondrion; cytoplasm; nucleolus; cytosol; actin cytoskeleton

Molecular Function: protein binding; acetyl-CoA carboxylase activity; metal ion binding; biotin carboxylase activity; ATP binding

Biological Process: vitamin metabolic process; acetyl-CoA metabolic process; multicellular organismal protein metabolic process; tissue homeostasis; positive regulation of cellular metabolic process; energy reserve metabolic process; lipid homeostasis; triacylglycerol biosynthetic process; carnitine shuttle; cellular lipid metabolic process; water-soluble vitamin metabolic process; fatty acid biosynthetic process; biotin metabolic process; protein homotetramerization

Disease: Acetyl-coa Carboxylase Deficiency

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ACACA antibody

Products by Pathway	Pathway Diagram
AMP-activated Protein Kinase (AMPK) Signaling Pathway antibodies	AMP-activated Protein Kinase (AMPK) Signaling Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
AMPK Signaling Pathway antibodies	AMPK Signaling Pathway Diagram
Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies	Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
Biotin Transport And Metabolism Pathway antibodies	Biotin Transport And Metabolism Pathway Diagram
ChREBP Activates Metabolic Gene Expression Pathway antibodies	ChREBP Activates Metabolic Gene Expression Pathway Diagram
Corticotropin-releasing Hormone Signaling Pathway antibodies	Corticotropin-releasing Hormone Signaling Pathway Diagram
Defective HLCS Causes Multiple Carboxylase Deficiency Pathway antibodies	Defective HLCS Causes Multiple Carboxylase Deficiency Pathway Diagram
Defects In Biotin (Btn) Metabolism Pathway antibodies	Defects In Biotin (Btn) Metabolism Pathway Diagram
Defects In Vitamin And Cofactor Metabolism Pathway antibodies	Defects In Vitamin And Cofactor Metabolism Pathway Diagram