• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

AIM2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8589603

Interferon-inducible protein AIM2 (Absent in melanoma 2) is a 343 amino acid protein belonging to the HIN-200 family. Induced by IFN-gamma, AIM2 is thought to act as a tumor suppressor by repressing NFkappaB transcriptional activity. Localized to the nucleus,… More details

$400 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
AIM2, Polyclonal Antibody
Full Product Name
AIM2 Antibody
Product Gene Name
anti-AIM2 antibody
Product Synonym Names
PYHIN4
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Purity/Purification
Antigen affinity purification.
Specificity
The antibody detects endogenous levels of total AIM2 protein.
Preparation and Storage
Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze/thaw cycles.
Molecular Weight
38,954 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (159032275..159046647, complement). Location: 1q22
OMIM
604578
3D Structure
ModBase 3D Structure for O14862
Immunogen
Fusion protein corresponding to a region derived from internal residues of human absent in melanoma 2

Product Categories/Family for anti-AIM2 antibody

Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-AIM2 antibody
Immunohistochemistry (IHC)
Application Notes for anti-AIM2 antibody
IHC: 1:50-1:200

Other Notes

Small volumes of anti-AIM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AIM2 purchase

MBS8589603 is an antibody targeting AIM2. Also known as AIM2 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AIM2. It may not necessarily be applicable to this product.

NCBI GI #
4757734
NCBI GeneID
9447
NCBI Accession #
NP_004824.1
UniProt Primary Accession #
O14862
UniProt Secondary Accession #
Q5T3V9; Q96FG9; A8K7M7
UniProt Related Accession #
O14862
GenBank Nucleotide #
NM_004833.1
NCBI Official Full Name
interferon-inducible protein AIM2
NCBI Official Synonym Full Names
absent in melanoma 2
NCBI Official Symbol
AIM2
NCBI Official Synonym Symbols
PYHIN4
UniProt Protein Name
Interferon-inducible protein AIM2
UniProt Synonym Protein Names
Absent in melanoma 2
Protein Family
Interferon-inducible protein
UniProt Gene Name
AIM2
UniProt Entry Name
AIM2_HUMAN
NCBI Protein Information
interferon-inducible protein AIM2

NCBI Summary for AIM2

AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]

UniProt Comments for AIM2

AIM2: a tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. Induced by interferon gamma. Defects in AIM2 may be a cause of microsatellite unstable colon cancers. AIM2 and various NOD-like receptors form multiprotein complexes called inflammasomes, which mediate caspase-1-dependent processing of pro-IL-1beta.

Protein type: Tumor suppressor

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: identical protein binding; protein binding; double-stranded DNA binding

Biological Process: positive regulation of protein oligomerization; positive regulation of interleukin-1 beta production; tumor necrosis factor-mediated signaling pathway; apoptosis; inhibition of NF-kappaB transcription factor; innate immune response; immune response; interleukin-1 beta secretion; positive regulation of interleukin-1 beta secretion; inflammatory response; positive regulation of defense response to virus by host; activation of innate immune response; activation of NF-kappaB transcription factor
Show more

Research Articles on AIM2

1. Our data highlight the dynamics of epidermal AIM2 expression, showing Langerhans cell and melanocyte-restricted expression in normal epidermis but a pronounced induction in subpopulations of epidermal keratinocytes under inflammatory conditions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-AIM2 antibody

 Products by Pathway  Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammasomes Pathway antibodies  Inflammasomes Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 NOD Pathway antibodies  NOD Pathway Diagram
 Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways antibodies  Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways Diagram
 The AIM2 Inflammasome Pathway antibodies  The AIM2 Inflammasome Pathway Diagram

Diseases associated with anti-AIM2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >46 publications with AIM2 and Inflammation
 Neoplasms Antibodies  >24 publications with AIM2 and Neoplasms
 Autoimmune Diseases Antibodies  >17 publications with AIM2 and Autoimmune Diseases
 Breast Neoplasms Antibodies  >4 publications with AIM2 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with AIM2 and Neoplasms, Experimental
 Head and Neck Neoplasms Antibodies  >3 publications with AIM2 and Head and Neck Neoplasms
 Lymphatic Diseases Antibodies  >3 publications with AIM2 and Lymphatic Diseases
 Lymphoma, B-Cell Antibodies  >2 publications with AIM2 and Lymphoma, B-Cell
 Nervous System Diseases Antibodies  >2 publications with AIM2 and Nervous System Diseases
 Glioma Antibodies  >2 publications with AIM2 and Glioma

Organs/Tissues associated with anti-AIM2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >20 publications with AIM2 and Blood
 Bone Antibodies  >10 publications with AIM2 and Bone
 Intestine Antibodies  >5 publications with AIM2 and Intestine
 Lung Antibodies  >5 publications with AIM2 and Lung
 Brain Antibodies  >4 publications with AIM2 and Brain
 Mouth Antibodies  >2 publications with AIM2 and Mouth
 Cervix Antibodies  >1 publications with AIM2 and Cervix
 Spleen Antibodies  >1 publications with AIM2 and Spleen
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000