Rabbit Anti-AKAP13 Polyclonal Antibody – Cat# MBS6369244

Western Blot analysis of AKAP13 expression in transfected 293T cell line by AKAP13 polyclonal antibody. Lane 1: AKAP13 transfected lysate (120.2kD). Lane 2: Non-transfected lysate.

AKAP13 Antibody – Rabbit Polyclonal

Name: AKAP13 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6369244
Price: 1165 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6369244

AKAP13 functions as a protein kinase A (PKA)-anchoring protein and acts as an adapter protein to selectively couple G alpha-13 and Rho. It contains a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with… More details

$1165 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AKAP13, Polyclonal Antibody

Full Product Name

AKAP13 (A-kinase Anchor Protein 13, AKAP-13, AKAP-Lbc, Breast Cancer Nuclear Receptor-binding Auxiliary Protein, Guanine Nucleotide Exchange Factor Lbc, Human Thyroid-anchoring Protein 31, Lymphoid Blast Crisis Oncogene, LBC Oncogene, Non-oncogenic Rho GT

Product Gene Name

anti-AKAP13 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Specificity

Recognizes human AKAP13.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Chromosome Location

chromosome: 15; Location: 15q24-q25

OMIM

604686

3D Structure

ModBase 3D Structure for Q12802

Immunogen

Full length human AKAP13, aa1-1058 (NP_658913.1).

Immunogen Sequence

MSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC

Conjugate

Biotin

Note

Preservative Free

Product Categories/Family for anti-AKAP13 antibody

Antibodies; Protein Kinases

Applications Tested/Suitable for anti-AKAP13 antibody

Western Blot (WB)

Application Notes for anti-AKAP13 antibody

Applications are based on unconjugated antibody.

Other Notes

Small volumes of anti-AKAP13 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AKAP13 purchase

MBS6369244 is an antibody targeting AKAP13. Also known as AKAP13 (A-kinase Anchor Protein 13, AKAP-13, AKAP-Lbc, Breast Cancer Nuclear Receptor-binding Auxiliary Protein, Guanine Nucleotide Exchange Factor Lbc, Human Thyroid-anchoring Protein 31, Lymphoid Blast Crisis Oncogene, LBC Oncogene, Non-oncogenic Rho GT. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AKAP13. It may not necessarily be applicable to this product.

NCBI GI #

21493031

NCBI GeneID

11214

NCBI Accession #

NP_658913.1

UniProt Primary Accession #

Q12802

UniProt Secondary Accession #

Q14572; Q59FP6; Q86W90; Q8WXQ6; Q96JP6; Q96P79; Q9Y5T0; Q9Y5T6

UniProt Related Accession #

Q12802

GenBank Nucleotide #

NM_144767

NCBI Official Full Name

A-kinase anchor protein 13 isoform 3 [Homo sapiens]

NCBI Official Synonym Full Names

A kinase (PRKA) anchor protein 13

NCBI Official Symbol

AKAP13

NCBI Official Synonym Symbols

BRX; LBC; HA-3; Ht31; c-lbc; AKAP-Lbc; ARHGEF13; FLJ11952; FLJ43341; PROTO-LB; PROTO-LBC; AKAP13

UniProt Protein Name

A-kinase anchor protein 13

UniProt Synonym Protein Names

AKAP-Lbc; Breast cancer nuclear receptor-binding auxiliary protein; Guanine nucleotide exchange factor Lbc; Human thyroid-anchoring protein 31; Lymphoid blast crisis oncogene; LBC oncogene; Non-oncogenic Rho GTPase-specific GTP exchange factor; Protein kinase A-anchoring protein 13; PRKA13; p47

Protein Family

A-kinase anchor protein

UniProt Gene Name

AKAP13

UniProt Synonym Gene Names

BRX; HT31; LBC; AKAP-13; LBC oncogene; PRKA13

UniProt Entry Name

AKP13_HUMAN

NCBI Protein Information

A-kinase anchor protein 13; p47; AKAP-13; LBC oncogene; A-kinase anchoring protein; lymphoid blast crisis oncogene; human thyroid-anchoring protein 31; protein kinase A-anchoring protein 13; guanine nucleotide exchange factor Lbc; non-oncogenic Rho GTPase

UniProt Comments for AKAP13

AKAP13: Anchors cAMP-dependent protein kinase (PKA) and acts as an adapter protein to selectively couple G alpha-13 and Rho. Augments gene activation by the estrogen receptor in an element- specific and ligand-dependent manner. Activates estrogen receptor beta by a p38 MAPK-dependent pathway. Stimulates exchange activity on Rho proteins in vitro, but not on CDC42, Ras or Rac and may bind calcium ions. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; GEFs, Rac/Rho; Nuclear export; GEFs; Oncoprotein; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 15q24-q25

Cellular Component: membrane; perinuclear region of cytoplasm; cytoplasm; nucleus; cytosol

Molecular Function: protein binding; Rho guanyl-nucleotide exchange factor activity; signal transducer activity; Rho GTPase binding; cAMP-dependent protein kinase activity; metal ion binding; protein kinase A binding; protein complex scaffold

Biological Process: regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; nuclear export; regulation of protein kinase activity; protein amino acid phosphorylation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AKAP13 antibody

Reference Product	PubMed Publications
RHOA antibody	>17 publications with AKAP13 and RHOA
CTNNAL1 antibody	>2 publications with AKAP13 and CTNNAL1

Pathways associated with anti-AKAP13 antibody

Products by Pathway	Pathway Diagram
Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies	Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
G Protein Signaling Pathways antibodies	G Protein Signaling Pathways Diagram
G Alpha (12/13) Signalling Events Pathway antibodies	G Alpha (12/13) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
NRAGE Signals Death Through JNK Pathway antibodies	NRAGE Signals Death Through JNK Pathway Diagram
Regulation Of RhoA Activity Pathway antibodies	Regulation Of RhoA Activity Pathway Diagram
Rho GTPase Cycle Pathway antibodies	Rho GTPase Cycle Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram
Signaling By Rho GTPases Pathway antibodies	Signaling By Rho GTPases Pathway Diagram
Signalling By NGF Pathway antibodies	Signalling By NGF Pathway Diagram

Diseases associated with anti-AKAP13 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>19 publications with AKAP13 and Neoplasms
Cell Transformation, Neoplastic Antibodies	>7 publications with AKAP13 and Cell Transformation, Neoplastic
Carcinoma Antibodies	>5 publications with AKAP13 and Carcinoma
Breast Neoplasms Antibodies	>4 publications with AKAP13 and Breast Neoplasms
Recurrence Antibodies	>3 publications with AKAP13 and Recurrence
Leukemia Antibodies	>3 publications with AKAP13 and Leukemia
Leukemia, Myeloid Antibodies	>3 publications with AKAP13 and Leukemia, Myeloid
Leukemia, Myeloid, Acute Antibodies	>2 publications with AKAP13 and Leukemia, Myeloid, Acute
Skin Diseases Antibodies	>2 publications with AKAP13 and Skin Diseases
Gallbladder Neoplasms Antibodies	>1 publications with AKAP13 and Gallbladder Neoplasms

Organs/Tissues associated with anti-AKAP13 antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>3 publications with AKAP13 and Kidney
Lung Antibodies	>2 publications with AKAP13 and Lung
Uterus Antibodies	>2 publications with AKAP13 and Uterus
Liver Antibodies	>1 publications with AKAP13 and Liver
Brain Antibodies	>1 publications with AKAP13 and Brain