Rabbit Anti-AKR1E2 Polyclonal Antibody – Cat# MBS6272586

AKR1E2 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the AKR1E2 antibody detected the AKR1E2 protein (arrow).

AKR1E2 Antibody – Rabbit Polyclonal

Name: AKR1E2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6272586
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6272586

AKR1E2 catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. Can also catalyze the reduction of various aldehydes and quinones (By similarity). Has low NADPH-dependent reductase activity towards… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AKR1E2, Polyclonal Antibody

Full Product Name

AKR1E2, CT (AKR1E2, AKR1CL2, AKRDC1, 1,5-anhydro-D-fructose reductase, Aldo-keto reductase family 1 member C-like protein 2, Aldo-keto reductase family 1 member E2, LoopADR, Testis-specific protein) (AP)

Product Gene Name

anti-AKR1E2 antibody

Product Synonym Names

AKR1E2; AKR1CL2; AKRDC1; 1,5-anhydro-D-fructose reductase; Aldo-keto reductase family 1 member C-like protein 2; Aldo-keto reductase family 1 member E2; LoopADR; Testis-specific protein

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

36,589 Da

Chromosome Location

Chromosome: 10; NC_000010.10 (4868369..4890254). Location: 10p15.1

3D Structure

ModBase 3D Structure for Q96JD6

Immunogen

AKR1E2 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 290-320 amino acids selected from the C-terminal region of human AKR1E2.

Conjugate

Note

Preservative Free

Product Categories/Family for anti-AKR1E2 antibody

Antibodies; Enzymes; Reductase

Applications Tested/Suitable for anti-AKR1E2 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-AKR1E2 antibody

WB: 1:100-500
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-AKR1E2 antibody

Clancy, R.M., et al. Arthritis Rheum. 62(11):3415-3424(2010). Lamesch, P., et al. Genomics 89(3):307-315(2007). Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006). Azuma, Y., et al. Mol. Hum. Reprod. 10(7):527-533(2004). Nishinaka, T., et al. Chem. Biol. Interact. 143-144, 299-305 (2003).

Other Notes

Small volumes of anti-AKR1E2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AKR1E2 purchase

MBS6272586 is an antibody targeting AKR1E2. Also known as AKR1E2, CT (AKR1E2, AKR1CL2, AKRDC1, 1,5-anhydro-D-fructose reductase, Aldo-keto reductase family 1 member C-like protein 2, Aldo-keto reductase family 1 member E2, LoopADR, Testis-specific protein) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AKR1E2. It may not necessarily be applicable to this product.

NCBI GI #

93277124

NCBI GeneID

83592

NCBI Accession #

NP_001035267.1

UniProt Primary Accession #

Q96JD6

UniProt Secondary Accession #

Q86Z16; Q86Z17; Q86Z18; Q9BU71

UniProt Related Accession #

Q96JD6

GenBank Nucleotide #

NM_001040177.2

NCBI Official Full Name

1,5-anhydro-D-fructose reductase isoform 1

NCBI Official Synonym Full Names

aldo-keto reductase family 1, member E2

NCBI Official Symbol

AKR1E2

NCBI Official Synonym Symbols

hTSP; htAKR; AKRDC1; AKR1CL2; LoopADR

UniProt Protein Name

1,5-anhydro-D-fructose reductase

UniProt Synonym Protein Names

Aldo-keto reductase family 1 member C-like protein 2; Aldo-keto reductase family 1 member E2; LoopADR; Testis-specific protein

Protein Family

1,5-anhydro-D-fructose reductase

UniProt Gene Name

AKR1E2

UniProt Synonym Gene Names

AKR1CL2; AKRDC1; AF reductase; hTSP

UniProt Entry Name

AKCL2_HUMAN

NCBI Protein Information

1,5-anhydro-D-fructose reductase; AF reductase; testis-specific protein; aldo-keto reductase loopADR; aldo-keto reductase family 1, member C-like 2; aldo-keto reductase family 1 member C-like protein 2

NCBI Summary for AKR1E2

The protein encoded by this gene is a member of the aldo-keto reductase superfamily. Members in this family are characterized by their structure (evolutionarily highly conserved TIM barrel) and function (NAD(P)H-dependent oxido-reduction of carbonyl groups). Transcripts of this gene have been reported in specimens of human testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

UniProt Comments for AKR1E2

AKR1CL2: Catalyzes the NADPH-dependent reduction of 1,5-anhydro- D-fructose (AF) to 1,5-anhydro-D-glucitol. Can also catalyze the reduction of various aldehydes and quinones. Has low NADPH-dependent reductase activity towards 9,10- phenanthrenequinone (in vitro). Belongs to the aldo/keto reductase family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; EC 1.1.1.263

Chromosomal Location of Human Ortholog: 10p15.1

Cellular Component: cytoplasm

Molecular Function: 1,5-anhydro-D-fructose reductase activity

Research Articles on AKR1E2

1. Observational study of gene-disease association. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-AKR1E2 antibody

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>1 publications with AKR1E2 and Eye