Rabbit Anti-ALDH1A1 Polyclonal Antibody – Cat# MBS8105297

ALDH1A1 Antibody – Rabbit Polyclonal

Name: ALDH1A1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS8105297
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8105297

Aldehyde dehydrogenase 1 family, member A1 (ALDH1A1), also known as Aldehyde dehydrogenase 1 (ALDH1), or Retinaldehyde Dehydrogenase 1 (RALDH1), is an enzyme that is expressed at high levels in stem cells and that has been suggested to regulate stem cell… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ALDH1A1, Polyclonal Antibody

Full Product Name

Anti-ALDH1A1 Antibody, Rabbit Polyclonal

Product Gene Name

anti-ALDH1A1 antibody

Product Synonym Names

ALDH1/ALDH1A1/ALDC Antibody, Rabbit PAb; aldehyde dehydrogenase 1 family, member A1; Anti-ALDC Antibody; Anti-ALDH-E1 Antibody; Anti-ALDH1 Antibody; Anti-ALDH11 Antibody; Anti-HEL-9 Antibody; Anti-HEL-S-53e Antibody; Anti-HEL12 Antibody; Anti-PUMB1 Antibody; Anti-RALDH1 Antibody

Clonality

Polyclonal

Isotype

Rabbit IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid; 0.2um filtered solution in PBS

Purity/Purification

Protein A

Specificity

Human ALDH1/ALDH1A1/ALDC

Preparation and Storage

This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Molecular Weight

54,862 Da

OMIM

100640

3D Structure

ModBase 3D Structure for P00352

Immunogen

Recombinant Human ALDH1 protein

Conjugation

Unconjugated

Preparation

Produced in rabbits immunized with purified, recombinant Human ALDH1 (rh ALDH1). Total IgG was purified by Protein A affinity chromatography .

Applications Tested/Suitable for anti-ALDH1A1 antibody

ELISA (EIA)

Application Notes for anti-ALDH1A1 antibody

ELISA: 1:1000-1:2000

Product References and Citations for anti-ALDH1A1 antibody

Li T, et al. (2010). ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome. Lab Invest. 90(2): 234-44.Levi BP, et al. (2009) Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Blood. 113(8): 1670-80.Rahman FB, et al. (2006) Uncompetitive inhibition of Xenopus laevis aldehyde dehydrogenase 1A1 by divalent cations. Zoolog Sci. 23(3): 239-44.Jester JV, et al. (1999). The cellular basis of corneal transparency: evidence for corneal crystallins. J Cell Sci. 112 (Pt 5): 613-22.

Other Notes

Small volumes of anti-ALDH1A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALDH1A1 purchase

MBS8105297 is an antibody targeting ALDH1A1. Also known as Anti-ALDH1A1 Antibody, Rabbit Polyclonal. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ALDH1A1. It may not necessarily be applicable to this product.

NCBI GI #

21361176

NCBI GeneID

216

NCBI Accession #

NP_000680.2

UniProt Primary Accession #

P00352

UniProt Secondary Accession #

O00768; Q5SYR1

UniProt Related Accession #

P00352

GenBank Nucleotide #

NM_000689.4

NCBI Official Full Name

retinal dehydrogenase 1

NCBI Official Synonym Full Names

aldehyde dehydrogenase 1 family, member A1

NCBI Official Symbol

ALDH1A1

NCBI Official Synonym Symbols

ALDC; ALDH1; HEL-9; HEL12; PUMB1; ALDH11; RALDH1; ALDH-E1; HEL-S-53e

UniProt Protein Name

Retinal dehydrogenase 1

UniProt Synonym Protein Names

ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic

Protein Family

Retinal dehydrogenase

UniProt Gene Name

ALDH1A1

UniProt Synonym Gene Names

ALDC; ALDH1; PUMB1; RALDH 1; RalDH1

UniProt Entry Name

AL1A1_HUMAN

NCBI Protein Information

retinal dehydrogenase 1; ALDH class 1; ALHDII; RALDH 1; acetaldehyde dehydrogenase 1; aldehyde dehydrogenase 1, soluble; aldehyde dehydrogenase, liver cytosolic; epididymis luminal protein 12; epididymis luminal protein 9; epididymis secretory sperm bindi

NCBI Summary for ALDH1A1

The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]

UniProt Comments for ALDH1A1

ALDH1A1: Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid. Belongs to the aldehyde dehydrogenase family.

Protein type: GAPs, Ras; EC 1.2.1.36; GAPs; Cofactor and Vitamin Metabolism - retinol; Apoptosis; Oxidoreductase

Chromosomal Location of Human Ortholog: 9q21.13

Cellular Component: cytoplasm; cytosol

Molecular Function: aldehyde dehydrogenase (NAD) activity; androgen binding; 3-chloroallyl aldehyde dehydrogenase activity; benzaldehyde dehydrogenase (NAD+) activity; retinal dehydrogenase activity

Biological Process: retinol metabolic process; xenobiotic metabolic process; aldehyde metabolic process; ethanol oxidation

Research Articles on ALDH1A1

1. Decreased expression of RALDH1 gene is associated with disease progression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ALDH1A1 antibody

Reference Product	PubMed Publications
ADH1B antibody	>11 publications with ALDH1A1 and ADH1B
CYP26B1 antibody	>10 publications with ALDH1A1 and CYP26B1
CYP26A1 antibody	>7 publications with ALDH1A1 and CYP26A1
CYP3A4 antibody	>5 publications with ALDH1A1 and CYP3A4
ADH5 antibody	>4 publications with ALDH1A1 and ADH5
ADH1A antibody	>4 publications with ALDH1A1 and ADH1A
ADH7 antibody	>3 publications with ALDH1A1 and ADH7
CYP26C1 antibody	>2 publications with ALDH1A1 and CYP26C1
ADH6 antibody	>2 publications with ALDH1A1 and ADH6

Pathways associated with anti-ALDH1A1 antibody

Products by Pathway	Pathway Diagram
Biological Oxidations Pathway antibodies	Biological Oxidations Pathway Diagram
Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway antibodies	Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway Diagram
Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway antibodies	Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway Diagram
Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway antibodies	Defective CYP11B2 Causes Corticosterone Methyloxidase 1 Deficiency (CMO-1 Deficiency) Pathway Diagram
Defective CYP17A1 Causes Adrenal Hyperplasia 5 (AH5) Pathway antibodies	Defective CYP17A1 Causes Adrenal Hyperplasia 5 (AH5) Pathway Diagram
Defective CYP19A1 Causes Aromatase Excess Syndrome (AEXS) Pathway antibodies	Defective CYP19A1 Causes Aromatase Excess Syndrome (AEXS) Pathway Diagram
Defective CYP1B1 Causes Glaucoma Pathway antibodies	Defective CYP1B1 Causes Glaucoma Pathway Diagram
Defective CYP21A2 Causes Adrenal Hyperplasia 3 (AH3) Pathway antibodies	Defective CYP21A2 Causes Adrenal Hyperplasia 3 (AH3) Pathway Diagram
Defective CYP24A1 Causes Hypercalcemia, Infantile (HCAI) Pathway antibodies	Defective CYP24A1 Causes Hypercalcemia, Infantile (HCAI) Pathway Diagram
Defective CYP26B1 Causes Radiohumeral Fusions With Other Skeletal And Craniofacial Anomalies (RHFCA) Pathway antibodies	Defective CYP26B1 Causes Radiohumeral Fusions With Other Skeletal And Craniofacial Anomalies (RHFCA) Pathway Diagram

Diseases associated with anti-ALDH1A1 antibody

Disease Name	Pubmed Publications
Lung Neoplasms Antibodies	>29 publications with ALDH1A1 and Lung Neoplasms
Breast Neoplasms Antibodies	>22 publications with ALDH1A1 and Breast Neoplasms
Disease Models, Animal Antibodies	>21 publications with ALDH1A1 and Disease Models, Animal
Neoplasms, Experimental Antibodies	>19 publications with ALDH1A1 and Neoplasms, Experimental
Brain Diseases Antibodies	>18 publications with ALDH1A1 and Brain Diseases
Nervous System Diseases Antibodies	>18 publications with ALDH1A1 and Nervous System Diseases
Liver Diseases Antibodies	>15 publications with ALDH1A1 and Liver Diseases
Liver Neoplasms Antibodies	>12 publications with ALDH1A1 and Liver Neoplasms
Parkinsonian Disorders Antibodies	>11 publications with ALDH1A1 and Parkinsonian Disorders
Inflammation Antibodies	>8 publications with ALDH1A1 and Inflammation

Organs/Tissues associated with anti-ALDH1A1 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>44 publications with ALDH1A1 and Lung
Liver Antibodies	>40 publications with ALDH1A1 and Liver
Blood Antibodies	>39 publications with ALDH1A1 and Blood
Brain Antibodies	>36 publications with ALDH1A1 and Brain
Eye Antibodies	>29 publications with ALDH1A1 and Eye
Prostate Antibodies	>15 publications with ALDH1A1 and Prostate
Bone Antibodies	>13 publications with ALDH1A1 and Bone
Testis Antibodies	>12 publications with ALDH1A1 and Testis
Intestine Antibodies	>12 publications with ALDH1A1 and Intestine
Kidney Antibodies	>11 publications with ALDH1A1 and Kidney