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ALKBH8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8593604

ALKBH8 (alkylated DNA repair protein AlkB homolog 8) is a 664 amino acid protein that is encoded by a gene located on chromosome 11. ALKBH8 contains one RRM (RNA recognition motif) domain and belongs to the AlkB family of proteins. ALKBH8 is one of many… More details

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Product Overview

Online Datasheet in PDF
Product Name
ALKBH8, Polyclonal Antibody
Full Product Name
ALKBH8 Antibody
Product Gene Name
anti-ALKBH8 antibody
Product Synonym Names
ABH8; TRM9; TRMT9
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Purity/Purification
Antigen affinity purification.
Specificity
The antibody detects endogenous levels of total ALKBH8 protein.
Preparation and Storage
Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze/thaw cycles.
Molecular Weight
75,208 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (107373453..107436461, complement). Location: 11q22.3
OMIM
613306
3D Structure
ModBase 3D Structure for Q96BT7
Immunogen
Full length fusion protein of human ALKBH8

Product Categories/Family for anti-ALKBH8 antibody

Primary Antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ALKBH8 antibody
Immunohistochemistry (IHC)
Application Notes for anti-ALKBH8 antibody
IHC: 1:25-1:100

Other Notes

Small volumes of anti-ALKBH8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALKBH8 purchase

MBS8593604 is an antibody targeting ALKBH8. Also known as ALKBH8 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ALKBH8. It may not necessarily be applicable to this product.

NCBI GI #
195927056
NCBI GeneID
91801
NCBI Accession #
NP_620130.2
UniProt Primary Accession #
Q96BT7
UniProt Secondary Accession #
Q8N989; B1Q2M0; B4DEF6
UniProt Related Accession #
Q96BT7
GenBank Nucleotide #
NM_138775.2
NCBI Official Full Name
alkylated DNA repair protein alkB homolog 8
NCBI Official Synonym Full Names
alkB, alkylation repair homolog 8 (E. coli)
NCBI Official Symbol
ALKBH8
NCBI Official Synonym Symbols
ABH8; FLJ38204; MGC10235
UniProt Protein Name
Alkylated DNA repair protein alkB homolog 8
UniProt Synonym Protein Names
Probable alpha-ketoglutarate-dependent dioxygenase ABH8; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8
Protein Family
Alkylated DNA repair protein
UniProt Gene Name
ALKBH8
UniProt Synonym Gene Names
ABH8
UniProt Entry Name
ALKB8_HUMAN
NCBI Protein Information
alkylated DNA repair protein alkB homolog 8; AlkB homologue 8; OTTHUMP00000211286; OTTHUMP00000211287; OTTHUMP00000232587; probable alpha-ketoglutarate-dependent dioxygenase ABH8; S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8

UniProt Comments for ALKBH8

ALKBH8: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis. Belongs to the alkB family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.1.1.229; Methyltransferase; RNA processing

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: microtubule cytoskeleton; nucleoplasm; nucleus; cytosol

Molecular Function: protein binding; zinc ion binding; tRNA (uracil) methyltransferase activity; iron ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; tRNA binding

Biological Process: tRNA wobble uridine modification; response to DNA damage stimulus; tRNA methylation
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Research Articles on ALKBH8

1. Data show that human AlkB homolog 8 (ABH8) catalyzes tRNA methylation to generate 5-methylcarboxymethyl uridine (mcm(5)U) at the wobble position of certain tRNAs, a critical anticodon loop modification linked to DNA damage survival.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-ALKBH8 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1 publications with ALKBH8 and Neoplasms
 Carcinoma Antibodies  >1 publications with ALKBH8 and Carcinoma

Organs/Tissues associated with anti-ALKBH8 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with ALKBH8 and Blood
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