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AMBP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6273148

MBS6273148 is an antibody targeting AMBP. Also known as AMBP, NT (AMBP, HCP, ITIL, Protein AMBP, Alpha-1-microglobulin, Alpha-1 microglycoprotein, Complex-forming glycoprotein heterogeneous in charge, Inter-alpha-trypsin inhibitor light chain, Bikunin, EDC1,… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
AMBP, Polyclonal Antibody
Full Product Name
AMBP, NT (AMBP, HCP, ITIL, Protein AMBP, Alpha-1-microglobulin, Alpha-1 microglycoprotein, Complex-forming glycoprotein heterogeneous in charge, Inter-alpha-trypsin inhibitor light chain, Bikunin, EDC1, HI-30, Uronic-acid-rich protein, Trypstatin) (APC)
Product Gene Name
anti-AMBP antibody
Product Synonym Names
AMBP; HCP; ITIL; Protein AMBP; Alpha-1-microglobulin; Alpha-1 microglycoprotein; Complex-forming glycoprotein heterogeneous in charge; Inter-alpha-trypsin inhibitor light chain; Bikunin; EDC1; HI-30; Uronic-acid-rich protein; Trypstatin
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
OMIM
176870
3D Structure
ModBase 3D Structure for P02760
Immunogen
AMBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 76-104 amino acids from the N-terminal region of human AMBP.
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-AMBP antibody

Antibodies; Carbohydrates; Glycoproteins
Applications Tested/Suitable for anti-AMBP antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-AMBP antibody
IHC: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-AMBP antibody

AMBP Antibody (N-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the AMBP antibody detected the AMBP protein (arrow).
Rabbit Anti-AMBP Polyclonal Antibody – Cat# MBS6273148

Immunohistochemistry (IHC) of anti-AMBP antibody

AMBP Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of AMBP Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-AMBP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6273148

Product References and Citations for anti-AMBP antibody

Olsson, M.G., et al. Radiat. Res. 174(5):590-600(2010). Allhorn, M., et al. Blood 99(6):1894-1901(2002). Amoresano, A., et al. Eur. J. Biochem. 267(7):2105-2112(2000). Xu, Y., et al. J. Mol. Biol. 276(5):955-966(1998). Vetr, H., et al. Biol. Chem. Hoppe-Seyler 371(12):1185-1196(1990).

Other Notes

Small volumes of anti-AMBP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for AMBP. It may not necessarily be applicable to this product.

NCBI GI #
4502067
NCBI GeneID
259
NCBI Accession #
NP_001624.1
UniProt Primary Accession #
P02760
UniProt Secondary Accession #
P00977; P02759; P78491; Q2TU33; Q5TBD7; Q9UC58; Q9UDI8
UniProt Related Accession #
P02760
GenBank Nucleotide #
NM_001633.3
NCBI Official Full Name
protein AMBP preproprotein
NCBI Official Synonym Full Names
alpha-1-microglobulin/bikunin precursor
NCBI Official Symbol
AMBP
NCBI Official Synonym Symbols
A1M; HCP; ITI; UTI; EDC1; HI30; ITIL; IATIL; ITILC
UniProt Protein Name
Protein AMBP
UniProt Synonym Protein Names
Alpha-1 microglycoprotein; Complex-forming glycoprotein heterogeneous in charge
Protein Family
Protein
UniProt Gene Name
AMBP
UniProt Synonym Gene Names
HCP; ITIL; Protein HC; ITI-LC
UniProt Entry Name
AMBP_HUMAN
NCBI Protein Information
protein AMBP; bikunin; complex-forming glycoprotein heterogeneous in charge; growth-inhibiting protein 19; inter-alpha-trypsin inhibitor light chain; protein HC; trypstatin; uristatin; uronic-acid-rich protein

NCBI Summary for AMBP

This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]
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UniProt Comments for AMBP

AMBP: Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9q32-q33

Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; plasma membrane; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; protein homodimerization activity; calcium oxalate binding; IgA binding; heme binding; calcium channel inhibitor activity

Biological Process: negative regulation of JNK cascade; receptor-mediated endocytosis; viral reproduction; heme catabolic process; negative regulation of immune response; protein catabolic process; female pregnancy; cell adhesion; protein-chromophore linkage
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Research Articles on AMBP

1. The antioxidative protection of cells and collagen by A1M is totally dependent on its C34 amino acid residue.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AMBP antibody

 Reference Product  PubMed Publications
 APOA1 antibody  >2 publications with AMBP and APOA1
 SERPINC1 antibody  >2 publications with AMBP and SERPINC1
 AHSG antibody  >2 publications with AMBP and AHSG
 ALB antibody  >2 publications with AMBP and ALB
 FGG antibody  >1 publications with AMBP and FGG
 ITIH3 antibody  >1 publications with AMBP and ITIH3
 ITIH2 antibody  >1 publications with AMBP and ITIH2

Pathways associated with anti-AMBP antibody

 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Scavenging Of Heme From Plasma Pathway antibodies  Scavenging Of Heme From Plasma Pathway Diagram

Diseases associated with anti-AMBP antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >45 publications with AMBP and Hypertension
 Inflammation Antibodies  >22 publications with AMBP and Inflammation
 Necrosis Antibodies  >16 publications with AMBP and Necrosis
 Kidney Diseases Antibodies  >12 publications with AMBP and Kidney Diseases
 Heart Diseases Antibodies  >12 publications with AMBP and Heart Diseases
 Hemorrhage Antibodies  >9 publications with AMBP and Hemorrhage
 Liver Diseases Antibodies  >7 publications with AMBP and Liver Diseases
 Drug-Induced Liver Injury Antibodies  >6 publications with AMBP and Drug-Induced Liver Injury
 Disease Models, Animal Antibodies  >5 publications with AMBP and Disease Models, Animal
 Hypertrophy Antibodies  >3 publications with AMBP and Hypertrophy

Organs/Tissues associated with anti-AMBP antibody

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >35 publications with AMBP and Heart
 Liver Antibodies  >29 publications with AMBP and Liver
 Kidney Antibodies  >22 publications with AMBP and Kidney
 Intestine Antibodies  >14 publications with AMBP and Intestine
 Brain Antibodies  >13 publications with AMBP and Brain
 Muscle Antibodies  >6 publications with AMBP and Muscle
 Lung Antibodies  >5 publications with AMBP and Lung
 Pancreas Antibodies  >3 publications with AMBP and Pancreas
 Embryonic Tissue Antibodies  >2 publications with AMBP and Embryonic Tissue
 Spleen Antibodies  >1 publications with AMBP and Spleen
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