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ANAPC1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9412456

This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation.… More details

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Product Overview

Online Datasheet in PDF
Product Name
ANAPC1, Polyclonal Antibody
Full Product Name
ANAPC1 Antibody
Product Gene Name
anti-ANAPC1 antibody
Product Synonym Names
APC1; MCPR; TSG24
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Purity/Purification
Antigen affinity purification.
Concentration
2.1 mg/ml (lot specific)
Specificity
The antibody detects endogenous levels of total ANAPC1 protein.
Preparation and Storage
Store at -20 degree C
Molecular Weight
216,500 Da
OMIM
608473
3D Structure
ModBase 3D Structure for Q9H1A4
Immunogen Type
Peptide
Immunogen Description
Synthetic peptide corresponding to a region derived from internal residues of human anaphase promoting complex subunit 1
Target Name
ANAPC1

Product Categories/Family for anti-ANAPC1 antibody

Total protein Ab
Applications Tested/Suitable for anti-ANAPC1 antibody
Immunohistochemistry (IHC)
Application Notes for anti-ANAPC1 antibody
Immunohistochemistry: 1:25-1:100

Immunohistochemistry (IHC) of anti-ANAPC1 antibody

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/30.
Rabbit Anti-ANAPC1 Polyclonal Antibody – Cat# MBS9412456

Other Notes

Small volumes of anti-ANAPC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ANAPC1 purchase

MBS9412456 is an antibody targeting ANAPC1. Also known as ANAPC1 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ANAPC1. It may not necessarily be applicable to this product.

NCBI GI #
12056971
NCBI GeneID
64682
NCBI Accession #
NP_073153.1
UniProt Primary Accession #
Q9H1A4
UniProt Secondary Accession #
Q2M3H8; Q9BSE6; Q9H8D0
UniProt Related Accession #
Q9H1A4
GenBank Nucleotide #
NM_022662.3
NCBI Official Full Name
anaphase-promoting complex subunit 1
NCBI Official Synonym Full Names
anaphase promoting complex subunit 1
NCBI Official Symbol
ANAPC1
NCBI Official Synonym Symbols
APC1; MCPR; TSG24
UniProt Protein Name
Anaphase-promoting complex subunit 1
UniProt Synonym Protein Names
Cyclosome subunit 1; Mitotic checkpoint regulator; Testis-specific gene 24 protein
UniProt Gene Name
ANAPC1
UniProt Synonym Gene Names
TSG24; APC1
UniProt Entry Name
APC1_HUMAN
NCBI Protein Information
anaphase-promoting complex subunit 1

NCBI Summary for ANAPC1

This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]

UniProt Comments for ANAPC1

APC1: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC1 family.

Protein type: Ubiquitin conjugating system; Cell cycle regulation

Chromosomal Location of Human Ortholog: 2q12.1

Cellular Component: nucleoplasm; anaphase-promoting complex; cytosol

Biological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle
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Research Articles on ANAPC1

1. Human Cytomegalovirus UL21a but not UL97 can disrupt APC/C function, leading to the accumulation of substrates and that UL21a is necessary and sufficient to induce the degradation of APC1, in addition to the previously reported APC4 and APC5.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ANAPC1 antibody

 Reference Product  PubMed Publications
 ANAPC2 antibody  >10 publications with ANAPC1 and ANAPC2
 CDC23 antibody  >7 publications with ANAPC1 and CDC23
 ANAPC4 antibody  >7 publications with ANAPC1 and ANAPC4
 CDC27 antibody  >7 publications with ANAPC1 and CDC27
 ANAPC5 antibody  >6 publications with ANAPC1 and ANAPC5
 ANAPC10 antibody  >6 publications with ANAPC1 and ANAPC10
 CDC16 antibody  >6 publications with ANAPC1 and CDC16
 CDC20 antibody  >3 publications with ANAPC1 and CDC20
 ANAPC7 antibody  >3 publications with ANAPC1 and ANAPC7

Pathways associated with anti-ANAPC1 antibody

 Products by Pathway  Pathway Diagram
 APC-Cdc20 Mediated Degradation Of Nek2A Pathway antibodies  APC-Cdc20 Mediated Degradation Of Nek2A Pathway Diagram
 APC/C Complex Pathway antibodies  APC/C Complex Pathway Diagram
 APC/C Complex Pathway antibodies  APC/C Complex Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Securin Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Securin Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway antibodies  APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway Diagram
 APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies  APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram

Diseases associated with anti-ANAPC1 antibody

 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >1 publications with ANAPC1 and Lung Diseases
 Adenocarcinoma Antibodies  >1 publications with ANAPC1 and Adenocarcinoma
 Hyperplasia Antibodies  >1 publications with ANAPC1 and Hyperplasia

Organs/Tissues associated with anti-ANAPC1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with ANAPC1 and Brain
 Lung Antibodies  >2 publications with ANAPC1 and Lung
 Skin Antibodies  >1 publications with ANAPC1 and Skin
 Kidney Antibodies  >1 publications with ANAPC1 and Kidney
 Uterus Antibodies  >1 publications with ANAPC1 and Uterus
 Stomach Antibodies  >1 publications with ANAPC1 and Stomach
 Intestine Antibodies  >1 publications with ANAPC1 and Intestine
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