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APOB48R Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6274399

Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If… More details

$1025 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
APOB48R, Polyclonal Antibody
Full Product Name
APOB48R, ID (APOBR, APOB48R, Apolipoprotein B receptor, Apolipoprotein B-100 receptor, Apolipoprotein B-48 receptor) (MaxLight 750)
Product Gene Name
anti-APOB48R antibody
Product Synonym Names
APOBR; APOB48R; Apolipoprotein B receptor; Apolipoprotein B-100 receptor; Apolipoprotein B-48 receptor
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
OMIM
605220
3D Structure
ModBase 3D Structure for Q0VD83
Immunogen
APOB48R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 595-622 amino acids from the Central region of human APOB48R.
Conjugate
MaxLight750
Note
Preservative Free

Product Categories/Family for anti-APOB48R antibody

Antibodies; Lipoproteins
Applications Tested/Suitable for anti-APOB48R antibody
Western Blot (WB), FLISA
Application Notes for anti-APOB48R antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-APOB48R antibody

Kawakami, A., et al. Arterioscler. Thromb. Vasc. Biol. 25(2):424-429(2005). Fujita, Y., et al. J. Hum. Genet. 50(4):203-209(2005). Brown, M.L., et al. Proc. Natl. Acad. Sci. U.S.A. 97(13):7488-7493(2000).

Other Notes

Small volumes of anti-APOB48R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APOB48R purchase

MBS6274399 is an antibody targeting APOB48R. Also known as APOB48R, ID (APOBR, APOB48R, Apolipoprotein B receptor, Apolipoprotein B-100 receptor, Apolipoprotein B-48 receptor) (MaxLight 750). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for APOB48R. It may not necessarily be applicable to this product.

NCBI GI #
119220598
NCBI GeneID
55911
NCBI Accession #
NP_061160.2
UniProt Primary Accession #
Q0VD83
UniProt Related Accession #
Q0VD83
GenBank Nucleotide #
NP_061160.2
NCBI Official Full Name
apolipoprotein B receptor
NCBI Official Synonym Full Names
apolipoprotein B receptor
NCBI Official Symbol
APOBR
NCBI Official Synonym Symbols
APOB48R; APOB100R
UniProt Protein Name
Apolipoprotein B receptor
UniProt Synonym Protein Names
Apolipoprotein B-100 receptor; Apolipoprotein B-48 receptor
UniProt Gene Name
APOBR
UniProt Synonym Gene Names
APOB48R; Apolipoprotein B48 receptor; apoB-48R
UniProt Entry Name
APOBR_HUMAN
NCBI Protein Information
apolipoprotein B receptor

NCBI Summary for APOB48R

Apolipoprotein B48 receptor is a macrophage receptor that binds to the apolipoprotein B48 of dietary triglyceride (TG)-rich lipoproteins. This receptor may provide essential lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. If overwhelmed with elevated plasma triglyceride, the apolipoprotein B48 receptor may contribute to foam cell formation, endothelial dysfunction, and atherothrombogenesis. [provided by RefSeq, Jul 2008]
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UniProt Comments for APOB48R

APOB48R: Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in macrophages. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.

Chromosomal Location of Human Ortholog: 16p11

Cellular Component: chylomicron; membrane; plasma membrane

Molecular Function: very-low-density lipoprotein receptor activity

Biological Process: receptor-mediated endocytosis; cholesterol metabolic process; triacylglycerol metabolic process; lipid transport
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Research Articles on APOB48R

1. the findings reported here demonstrated that patients with mutations in FASN (c.G7192T, p.A2398S) and APOBR (c.C1883G, p.T628R) may be predisposed to hypothyroidism. These mutations may disrupt the regulation of fatty acid biosynthesis and lipid metabolism. These findings may reveal the high degree of genetic heterogeneity in hypothyroidism phenotypes.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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