Rabbit Anti-ARAP2 Polyclonal Antibody – Cat# MBS9210201

ARAP2 Antibody (N-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the ARAP2 antibody detected the ARAP2 protein (arrow).

ARAP2 Antibody – Rabbit Polyclonal

Name: ARAP2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9210201
Price: 240 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9210201

$240 / 0.08 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ARAP2, Polyclonal Antibody

Full Product Name

ARAP2 Antibody (N-term)

Product Gene Name

anti-ARAP2 antibody

Product Synonym Names

Arf-GAP with Rho-GAP domain; ANK repeat and PH domain-containing protein 2; Centaurin-delta-1; Cnt-d1; Protein PARX; ARAP2; CENTD1; KIAA0580

Clonality

Polyclonal

Isotype

Rabbit Ig

Host

Rabbit

Species Reactivity

Human

Form/Format

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Purity/Purification

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Concentration

Vial Concentration: 0.5 (lot specific)

Specificity

This ARAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-93 amino acids from the N-terminal region of human ARAP2.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Antibody/Peptide Pairs

ARAP2 peptide (MBS9222131) is used for blocking the activity of ARAP2 antibody (MBS9210201)

Molecular Weight

193452

Immunogen Sequence Positions

63-93

OMIM

606645

3D Structure

ModBase 3D Structure for Q8WZ64

Antigen Type

Synthetic Peptide

Antigen Source

HUMAN

Product Categories/Family for anti-ARAP2 antibody

Signal Transduction

Applications Tested/Suitable for anti-ARAP2 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-ARAP2 antibody

WB~~1:1000

Product References and Citations for anti-ARAP2 antibody

Gavicherla, B., et al. Infect. Immun. 78(11):4532-4541(2010)
Liu, C., et al. Mol. Med. 14 (9-10), 575-581 (2008) :
Yoon, H.Y., et al. J. Cell. Sci. 119 (PT 22), 4650-4666 (2006) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)

Other Notes

Small volumes of anti-ARAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARAP2 purchase

MBS9210201 is an antibody targeting ARAP2. Also known as ARAP2 Antibody (N-term). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ARAP2. It may not necessarily be applicable to this product.

NCBI GI #

21264592

NCBI GeneID

116984

NCBI Accession #

NP_056045.2

UniProt Primary Accession #

Q8WZ64

UniProt Secondary Accession #

Q4W5D2; Q7Z2L5; Q96L70; Q96P49; Q9Y4E4

UniProt Related Accession #

Q8WZ64

GenBank Nucleotide #

NM_015230.3

NCBI Official Full Name

arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

NCBI Official Synonym Full Names

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

NCBI Official Symbol

ARAP2

NCBI Official Synonym Symbols

PARX; CENTD1

UniProt Protein Name

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

UniProt Synonym Protein Names

Centaurin-delta-1; Cnt-d1; Protein PARX

Protein Family

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein

UniProt Gene Name

ARAP2

UniProt Synonym Gene Names

CENTD1; KIAA0580; Cnt-d1

UniProt Entry Name

ARAP2_HUMAN

NCBI Protein Information

arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

NCBI Summary for ARAP2

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]

UniProt Comments for ARAP2

CENTD1: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency.

Protein type: GAPs, ARF; GAPs

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: cytosol

Molecular Function: phosphatidylinositol-3,4,5-triphosphate binding; zinc ion binding

Biological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; positive regulation of GTPase activity

Research Articles on ARAP2

1. ACAP1 and ARAP2 each colocalize with Arf6 but they did not colocalize with each other and have opposing effects on focal adhesions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ARAP2 antibody

Reference Product	PubMed Publications
ARF6 antibody	>5 publications with ARAP2 and ARF6
RHOA antibody	>3 publications with ARAP2 and RHOA
RAC1 antibody	>1 publications with ARAP2 and RAC1
CDC42 antibody	>1 publications with ARAP2 and CDC42

Diseases associated with anti-ARAP2 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>1 publications with ARAP2 and Inflammation

Organs/Tissues associated with anti-ARAP2 antibody

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>1 publications with ARAP2 and Prostate
Brain Antibodies	>1 publications with ARAP2 and Brain