ASNS Antibody – Rabbit Polyclonal

The protein encoded by this gene is involved in the synthesis of asparagine. This gene complements a mutation in the temperature-sensitive hamster mutant ts11, which blocks progression through the G1 phase of the cell cycle at nonpermissive temperature. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

ASNS: asparagine synthetase, an ubiquitous enzyme in mammalian organs, is involved in the first step of the synthesis of L-asparagine from L-glutamine and L-aspartate. Highly regulated in response to cell stress. Induced by dietary protein deficiency, imbalanced amino acid intake via the amino acid response, or ER stress via the EIF2AK3-eIF2-ATF4 branch of the unfolded protein response (UPR). Expression induced by nutrient deprivation or hypoxia in solid tumors. Essential for brain development but apparently not for that of other organs. Deficiency impairs brain development resulting in microcephaly and progressive cerebral atrophy, as well as deficiencies in learning and memory. The mechanism through which ASNS induces neuronal damage may be via damage induced by excessive excitability induced by elevated levels of aspartate/glutamate, via asparagine deficiency, or both. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Cell cycle regulation; Cell development/differentiation; EC 6.3.5.4; Energy Metabolism - nitrogen; Ligase

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: cytosol

Molecular Function: asparagine synthase (glutamine-hydrolyzing) activity; protein binding; protein homodimerization activity

Biological Process: amino acid biosynthetic process; asparagine biosynthetic process; cellular response to glucose starvation; glutamine metabolic process; negative regulation of apoptosis; positive regulation of mitotic cell cycle

Disease: Asparagine Synthetase Deficiency