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ATH1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6464344

MBS6464344 is an antibody targeting ATH1. Also known as ATH1, NT (Protein Atonal Homolog 1, Helix-loop-helix Protein hATH-1, Class A Basic Helix-loop-helix Protein 14, bHLHa14, ATOH1, MATH1, HATH1) (PE). Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ATH1, Polyclonal Antibody
Full Product Name
ATH1, NT (Protein Atonal Homolog 1, Helix-loop-helix Protein hATH-1, Class A Basic Helix-loop-helix Protein 14, bHLHa14, ATOH1, MATH1, HATH1) (PE)
Product Gene Name
anti-ATH1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Immunoaffinity chromatography.
Specificity
Recognizes human ATOH1.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
21.3 kDa (198aa)
OMIM
601461
3D Structure
ModBase 3D Structure for Q92858
Immunogen
Synthetic peptide selected from the N-terminal region of human ATOH1 (KLH).
Conjugate
PE
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-ATH1 antibody

Antibodies; Transcription Factors
Applications Tested/Suitable for anti-ATH1 antibody
Western Blot (WB), FLISA
Application Notes for anti-ATH1 antibody
WB: 1:50-1:100
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ATH1 antibody

Western blot analysis of ATOH1 (arrow) using rabbit polyclonal ATOH1 Antibody (Human N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ATOH1 gene (Lane 2) (Origene Technologies).
Rabbit Anti-ATH1 Polyclonal Antibody – Cat# MBS6464344

Product References and Citations for anti-ATH1 antibody

1. Aragaki, M., Biochem. Biophys. Res. Commun. 368(4), 923-929 (2008). 2. Scheffer, D., FEBS Lett. 581(24), 4651-4656 (2007).

Other Notes

Small volumes of anti-ATH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ATH1. It may not necessarily be applicable to this product.

NCBI GI #
4885075
NCBI GeneID
474
NCBI Accession #
NP_005163
UniProt Primary Accession #
Q92858
UniProt Secondary Accession #
Q14CT9
UniProt Related Accession #
Q92858
GenBank Nucleotide #
NM_005172.1
NCBI Official Full Name
protein atonal homolog 1
NCBI Official Synonym Full Names
atonal bHLH transcription factor 1
NCBI Official Symbol
ATOH1
NCBI Official Synonym Symbols
ATH1; HATH1; MATH-1; bHLHa14
UniProt Protein Name
Protein atonal homolog 1
UniProt Synonym Protein Names
Class A basic helix-loop-helix protein 14; bHLHa14; Helix-loop-helix protein hATH-1; hATH1
Protein Family
Homeobox protein
UniProt Gene Name
ATOH1
UniProt Synonym Gene Names
ATH1; BHLHA14; bHLHa14; hATH1
UniProt Entry Name
ATOH1_HUMAN
NCBI Protein Information
protein atonal homolog 1

NCBI Summary for ATH1

This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with E47. [provided by RefSeq, Jul 2008]

UniProt Comments for ATH1

ATOH1: a conserved transcription factor that regulates secretory cell differentiation in colonic epithelium. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box- dependent transcription . Efficient DNA binding requires dimerization with another bHLH protein. Loss of ATOH1 expression in the colon of mice initiates colon cancer. ATOH1 has been silenced in most human colon cancers, and reactivation of this gene in cultured human colon cancer cells is anti-proliferative and induces apoptosis.

Protein type: DNA-binding; Transcription factor; Cell development/differentiation

Chromosomal Location of Human Ortholog: 4q22

Cellular Component: nucleus

Molecular Function: protein dimerization activity; chromatin DNA binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; axon guidance; inner ear morphogenesis; central nervous system development; auditory receptor cell fate determination; neuron migration; positive regulation of transcription from RNA polymerase II promoter; positive regulation of auditory receptor cell differentiation; auditory receptor cell fate specification; cerebral cortex development; positive regulation of neuron differentiation; negative regulation of apoptosis
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Research Articles on ATH1

1. ATOH1 expression was detected consistently in recurrent and metastatic SHH medulloblastoma. Chromatin immunoprecipitation sequencing and gene expression profiling identified candidate ATOH1 targets in tumor cells involved in development and tumorigenesis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ATH1 antibody

 Reference Product  PubMed Publications
 SOX2 antibody  >28 publications with ATH1 and SOX2
 PROX1 antibody  >7 publications with ATH1 and PROX1
 HIC1 antibody  >5 publications with ATH1 and HIC1
 TCF4 antibody  >3 publications with ATH1 and TCF4
 MUC6 antibody  >2 publications with ATH1 and MUC6
 ZIC1 antibody  >2 publications with ATH1 and ZIC1
 HES6 antibody  >2 publications with ATH1 and HES6
 POU4F1 antibody  >1 publications with ATH1 and POU4F1

Diseases associated with anti-ATH1 antibody

 Disease Name  Pubmed Publications
 Medulloblastoma Antibodies  >33 publications with ATH1 and Medulloblastoma
 Brain Diseases Antibodies  >20 publications with ATH1 and Brain Diseases
 Inflammation Antibodies  >8 publications with ATH1 and Inflammation
 Colitis Antibodies  >7 publications with ATH1 and Colitis
 Hyperplasia Antibodies  >5 publications with ATH1 and Hyperplasia
 Necrosis Antibodies  >5 publications with ATH1 and Necrosis
 Ataxia Antibodies  >4 publications with ATH1 and Ataxia
 Lung Diseases Antibodies  >2 publications with ATH1 and Lung Diseases
 Intracranial Hypertension Antibodies  >1 publications with ATH1 and Intracranial Hypertension
 Hypertrophy Antibodies  >1 publications with ATH1 and Hypertrophy

Organs/Tissues associated with anti-ATH1 antibody

 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >1 publications with ATH1 and Mixed
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