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ATP6AP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6370726

ATP6AP1 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme, which is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. V-ATPase dependent organelle acidification is necessary for intracellular processes… More details

$1165 / 0.1 mL +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ATP6AP1, Polyclonal Antibody
Full Product Name
ATP6AP1 (V-type Proton ATPase Subunit S1, V-ATPase Subunit S1, Protein XAP-3, V-ATPase Ac45 Subunit, V-ATPase S1 Accessory Protein, Vacuolar Proton Pump Subunit S1, ATP6IP1, ATP6S1, VATPS1, XAP3) (PE)
Product Gene Name
anti-ATP6AP1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human ATP6AP1.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
52,026 Da
OMIM
300197
3D Structure
ModBase 3D Structure for Q15904
Immunogen
Full length human ATP6AP1, aa1-470 (NP_001174.2).
Immunogen Sequence
MMAAMATARVRMGPRCAQALWRMPWLPVFLSLAAAAAAAAAEQQVPLVLWSSDRDLWAPAADTHEGHITSDLQLSTYLDPALELGPRNVLLFLQDKLSIEDFTAYGGVFGNKQDSAFSNLENALDLAPSSLVLPAVDWYAVSTLTTYLQEKLGASPLHVDLATLRELKLNASLPALLLIRLPYTASSGLMAPREVLTGNDEVIGQVLSTLKSEDVPYTAALTAVRPSRVARDVAVVAGGLGRQLLQKQPVSPVIHPPVSYNDTAPRILFWAQNFSVAYKDQWEDLTPLTFGVQELNLTGSFWNDSFARLSLTYERLFGTTVTFKFILANRLYPVSARHWFTMERLEVHSNGSVAYFNASQVTGPSIYSFHCEYVSSLSKKGSLLVARTQPSPWQMMLQDFQIQAFNVMGEQFSYASDCASFFSPGIWMGLLTSLFMLFIFTYGLHMILSLKTMDRFDDHKGPTISLTQIV
Conjugate
PE
Note
Preservative Free

Product Categories/Family for anti-ATP6AP1 antibody

Antibodies; Enzymes; ATPase
Applications Tested/Suitable for anti-ATP6AP1 antibody
Western Blot (WB)
Application Notes for anti-ATP6AP1 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ATP6AP1 antibody

ATP6AP1 rabbit polyclonal antibody. Western Blot analysis of ATP6AP1 expression in human kidney.
Rabbit Anti-ATP6AP1 Polyclonal Antibody – Cat# MBS6370726

Western Blot (WB) of anti-ATP6AP1 antibody

Western Blot analysis of ATP6AP1 expression in transfected 293T cell line by ATP6AP1 polyclonal antibody. Lane 1: ATP6AP1 transfected lysate (52kD). Lane 2: Non-transfected lysate.
Rabbit Anti-ATP6AP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6370726

Other Notes

Small volumes of anti-ATP6AP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ATP6AP1 purchase

MBS6370726 is an antibody targeting ATP6AP1. Also known as ATP6AP1 (V-type Proton ATPase Subunit S1, V-ATPase Subunit S1, Protein XAP-3, V-ATPase Ac45 Subunit, V-ATPase S1 Accessory Protein, Vacuolar Proton Pump Subunit S1, ATP6IP1, ATP6S1, VATPS1, XAP3) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ATP6AP1. It may not necessarily be applicable to this product.

NCBI GI #
17136148
NCBI GeneID
537
NCBI Accession #
NP_001174.2
UniProt Primary Accession #
Q15904
UniProt Secondary Accession #
Q8NBT4; Q9H0C7; A6ZKI4
UniProt Related Accession #
Q15904
GenBank Nucleotide #
NM_001183.4
NCBI Official Full Name
V-type proton ATPase subunit S1
NCBI Official Synonym Full Names
ATPase H+ transporting accessory protein 1
NCBI Official Symbol
ATP6AP1
NCBI Official Synonym Symbols
16A; CF2; Ac45; XAP3; XAP-3; ATP6S1; VATPS1; ATP6IP1
UniProt Protein Name
V-type proton ATPase subunit S1
UniProt Synonym Protein Names
Protein XAP-3; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; Vacuolar proton pump subunit S1
Protein Family
V-type proton ATPase
UniProt Gene Name
ATP6AP1
UniProt Synonym Gene Names
ATP6IP1; ATP6S1; VATPS1; XAP3; V-ATPase subunit S1
UniProt Entry Name
VAS1_HUMAN
NCBI Protein Information
V-type proton ATPase subunit S1

NCBI Summary for ATP6AP1

This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]
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UniProt Comments for ATP6AP1

ATP6AP1: Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the vacuolar ATPase subunit S1 family.

Protein type: Transporter; EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: vacuolar membrane; integral to membrane; endosome membrane; proton-transporting two-sector ATPase complex

Molecular Function: transporter activity; hydrogen ion transporting ATP synthase activity, rotational mechanism; hydrogen ion transporting ATPase activity, rotational mechanism; Rab GTPase binding; ATP binding

Biological Process: positive regulation of osteoblast differentiation; proton transport; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; pH reduction; insulin receptor signaling pathway; positive regulation of bone resorption; transferrin transport; transmembrane transport; establishment of organelle localization; positive regulation of exocytosis
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Research Articles on ATP6AP1

1. ATP6AP1 is somatically mutated in 12% of follicular lymphoma tumors. Mutations clustered around the transmembrane domain.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ATP6AP1 antibody

 Reference Product  PubMed Publications
 ATP6V0D2 antibody  >2 publications with ATP6AP1 and ATP6V0D2
 ATP6AP2 antibody  >2 publications with ATP6AP1 and ATP6AP2
 ATP6V1E1 antibody  >1 publications with ATP6AP1 and ATP6V1E1
 ATP6V1F antibody  >1 publications with ATP6AP1 and ATP6V1F
 ATP6V0D1 antibody  >1 publications with ATP6AP1 and ATP6V0D1
 GDI1 antibody  >1 publications with ATP6AP1 and GDI1

Pathways associated with anti-ATP6AP1 antibody

 Products by Pathway  Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway antibodies  Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 Insulin Receptor Recycling Pathway antibodies  Insulin Receptor Recycling Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Oxidative Phosphorylation Pathway antibodies  Oxidative Phosphorylation Pathway Diagram

Diseases associated with anti-ATP6AP1 antibody

 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >7 publications with ATP6AP1 and Disease Models, Animal
 Nervous System Diseases Antibodies  >3 publications with ATP6AP1 and Nervous System Diseases
 Neoplasm Metastasis Antibodies  >2 publications with ATP6AP1 and Neoplasm Metastasis
 Inflammation Antibodies  >2 publications with ATP6AP1 and Inflammation
 Liver Diseases Antibodies  >1 publications with ATP6AP1 and Liver Diseases
 Hypertension Antibodies  >1 publications with ATP6AP1 and Hypertension
 Neurobehavioral Manifestations Antibodies  >1 publications with ATP6AP1 and Neurobehavioral Manifestations
 Fibrosis Antibodies  >1 publications with ATP6AP1 and Fibrosis
 Heart Diseases Antibodies  >1 publications with ATP6AP1 and Heart Diseases
 Congenital Abnormalities Antibodies  >1 publications with ATP6AP1 and Congenital Abnormalities

Organs/Tissues associated with anti-ATP6AP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with ATP6AP1 and Blood
 Brain Antibodies  >5 publications with ATP6AP1 and Brain
 Eye Antibodies  >3 publications with ATP6AP1 and Eye
 Liver Antibodies  >2 publications with ATP6AP1 and Liver
 Heart Antibodies  >1 publications with ATP6AP1 and Heart
 Muscle Antibodies  >1 publications with ATP6AP1 and Muscle
 Stomach Antibodies  >1 publications with ATP6AP1 and Stomach
 Lung Antibodies  >1 publications with ATP6AP1 and Lung
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