Rabbit Anti-ATXN7 Polyclonal Antibody – Cat# MBS6276824

ATXN7 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ATXN7 antibody detected the ATXN7 protein (arrow).

ATXN7 Antibody – Rabbit Polyclonal

Name: ATXN7 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6276824
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6276824

MBS6276824 is an antibody targeting ATXN7. Also known as ATXN7, ID (ATXN7, SCA7, Ataxin-7, Spinocerebellar ataxia type 7 protein) (FITC). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ATXN7, Polyclonal Antibody

Full Product Name

ATXN7, ID (ATXN7, SCA7, Ataxin-7, Spinocerebellar ataxia type 7 protein) (FITC)

Product Gene Name

anti-ATXN7 antibody

Product Synonym Names

ATXN7; SCA7; Ataxin-7; Spinocerebellar ataxia type 7 protein

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

95,451 Da

Chromosome Location

Chromosome: 3; NC_000003.11 (63850233..63989138). Location: 3p21.1-p12

OMIM

164500

3D Structure

ModBase 3D Structure for O15265

Immunogen

ATXN7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353-381 amino acids from the Central region of human ATXN7.

Conjugate

FITC

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-ATXN7 antibody

Antibodies; Ataxin

Applications Tested/Suitable for anti-ATXN7 antibody

Western Blot (WB), FLISA

Application Notes for anti-ATXN7 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-ATXN7 antibody

Bonnet, J., et al. EMBO Rep. 11(8):612-618(2010). Han, Y., et al. Neurol India 58(4):622-626(2010). Chou, A.H., et al. Neurochem. Int. 56(2):329-339(2010). Mookerjee, S., et al. J. Neurosci. 29(48):15134-15144(2009). Freund, A.A., et al. Arq Neuropsiquiatr 67(4):1124-1132(2009).

Other Notes

Small volumes of anti-ATXN7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ATXN7. It may not necessarily be applicable to this product.

NCBI GI #

4506797

NCBI GeneID

6314

NCBI Accession #

NP_000324.1

NCBI Related Accession #

NP_001170858.1

UniProt Primary Accession #

O15265

UniProt Secondary Accession #

O75328; O75329; Q9Y6P8

UniProt Related Accession #

O15265

GenBank Nucleotide #

NM_000333.3

NCBI Official Full Name

ataxin-7 isoform a

NCBI Official Synonym Full Names

ataxin 7

NCBI Official Symbol

ATXN7

NCBI Official Synonym Symbols

SCA7; OPCA3; ADCAII

UniProt Protein Name

Ataxin-7

UniProt Synonym Protein Names

Spinocerebellar ataxia type 7 protein

Protein Family

Ataxin

UniProt Gene Name

ATXN7

UniProt Synonym Gene Names

SCA7

UniProt Entry Name

ATX7_HUMAN

NCBI Protein Information

ataxin-7; spinocerebellar ataxia type 7 protein

UniProt Comments for ATXN7

ataxin-7: Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization. Defects in ATXN7 are the cause of spinocerebellar ataxia type 7 (SCA7); also known as olivopontocerebellar atrophy III (OPCA III or OPCA3) or olivopontocerebellar atrophy with retinal degeneration. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA7 belongs to the autosomal dominant cerebellar ataxias type II (ADCA II) which are characterized by cerebellar ataxia with retinal degeneration and pigmentary macular dystrophy. Belongs to the ataxin-7 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus; Transcription regulation

Chromosomal Location of Human Ortholog: 3p21.1-p12

Cellular Component: nucleoplasm; microtubule cytoskeleton; nuclear matrix; cytoplasm; nucleolus; nucleus

Molecular Function: protein binding; chromatin binding

Biological Process: establishment and/or maintenance of chromatin architecture; visual perception; transcription, DNA-dependent; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of phosphorylation; positive regulation of transcription from RNA polymerase II promoter; microtubule cytoskeleton organization and biogenesis; nuclear organization and biogenesis; histone deubiquitination

Disease: Spinocerebellar Ataxia 7

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ATXN7 antibody

Reference Product	PubMed Publications
TRRAP antibody	>1 publications with ATXN7 and TRRAP

Diseases associated with anti-ATXN7 antibody

Disease Name	Pubmed Publications
Cerebellar Ataxia Antibodies	>10 publications with ATXN7 and Cerebellar Ataxia
Nervous System Diseases Antibodies	>9 publications with ATXN7 and Nervous System Diseases
Central Nervous System Diseases Antibodies	>8 publications with ATXN7 and Central Nervous System Diseases
Spinocerebellar Ataxias Antibodies	>8 publications with ATXN7 and Spinocerebellar Ataxias
Eye Diseases Antibodies	>3 publications with ATXN7 and Eye Diseases
Nerve Degeneration Antibodies	>3 publications with ATXN7 and Nerve Degeneration
Movement Disorders Antibodies	>3 publications with ATXN7 and Movement Disorders
Death Antibodies	>2 publications with ATXN7 and Death
Drug Toxicity Antibodies	>1 publications with ATXN7 and Drug Toxicity
Breast Neoplasms Antibodies	>1 publications with ATXN7 and Breast Neoplasms

Organs/Tissues associated with anti-ATXN7 antibody

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>3 publications with ATXN7 and Eye
Brain Antibodies	>3 publications with ATXN7 and Brain
Heart Antibodies	>1 publications with ATXN7 and Heart