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B2-Microglobulin (HLA-G) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS624989

Beta-2-microglobulin is a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
b2-Microglobulin (HLA-G), Polyclonal Antibody
Full Product Name
b2-Microglobulin, NT (B2M, Beta-2-microglobulin, CDABP0092, HDCMA22P)
Product Gene Name
anti-HLA-G antibody
Product Synonym Names
Anti -b2-Microglobulin, NT (B2M, Beta-2-microglobulin, CDABP0092, HDCMA22P)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human B2M.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
31,549 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (29794756..29798899). Location: 6p21.3
3D Structure
ModBase 3D Structure for O02923
Immunogen
Synthetic peptide selected from the N-terminal region of human B2M (KLH).

Product Categories/Family for anti-HLA-G antibody

Antibodies; Abs to Serum Proteins
Applications Tested/Suitable for anti-HLA-G antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-HLA-G antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:10-1:50

Western Blot (WB) of anti-HLA-G antibody

Western blot analysis of B2M (arrow) using rabbit polyclonal B2M Antibody (N-term) (RB14679). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the B2M gene (Lane 2) (Origene Technologies).
Rabbit Anti-HLA-G Polyclonal Antibody – Cat# MBS624989

Flow Cytometry (FC/FACS) of anti-HLA-G antibody

B2M Antibody (N-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-HLA-G Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS624989

Immunohistochemistry (IHC) of anti-HLA-G antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with B2M antibody (N-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-HLA-G Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS624989

Other Notes

Small volumes of anti-HLA-G antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HLA-G purchase

MBS624989 is an antibody targeting HLA-G. Also known as b2-Microglobulin, NT (B2M, Beta-2-microglobulin, CDABP0092, HDCMA22P). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HLA-G. It may not necessarily be applicable to this product.

NCBI GI #
188468
NCBI GeneID
3135
UniProt Primary Accession #
O02923
UniProt Related Accession #
O02923; O02924; O02925; O02926; O02927; O02928; O02929; O19588; O19658; O19659
NCBI Official Full Name
b2 microglobulin
NCBI Official Synonym Full Names
major histocompatibility complex, class I, G
NCBI Official Symbol
HLA-G
NCBI Official Synonym Symbols
MHC-G
UniProt Protein Name
HLA-G protein
Protein Family
HLA class I histocompatibility antigen
UniProt Gene Name
HLA-G
UniProt Entry Name
O02923_HUMAN
NCBI Protein Information
HLA class I histocompatibility antigen, alpha chain G; HLA G antigen; b2 microglobulin; OTTHUMP00000029218; OTTHUMP00000029220; OTTHUMP00000033527; OTTHUMP00000159507; HLA class I molecule; MHC class I antigen G; HLA-G histocompatibility antigen, class I, G

NCBI Summary for HLA-G

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq]
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UniProt Comments for HLA-G

Sequence similarities: Belongs to the MHC class I family. RuleBase RU004439

Research Articles on HLA-G

1. We found the production of HLA-G and HLA-E in a majority of cases of glioblastoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HLA-G antibody

 Reference Product  PubMed Publications
 LILRB1 antibody  >45 publications with HLA-G and LILRB1
 LILRB2 antibody  >33 publications with HLA-G and LILRB2
 KLRD1 antibody  >26 publications with HLA-G and KLRD1
 KIR2DL4 antibody  >22 publications with HLA-G and KIR2DL4
 TAP1 antibody  >14 publications with HLA-G and TAP1
 TAP2 antibody  >9 publications with HLA-G and TAP2
 B2M antibody  >4 publications with HLA-G and B2M

Pathways associated with anti-HLA-G antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immunity Signaling Pathway antibodies  Adaptive Immunity Signaling Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies  Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram

Diseases associated with anti-HLA-G antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >254 publications with HLA-G and Neoplasms
 Carcinoma Antibodies  >108 publications with HLA-G and Carcinoma
 Adenocarcinoma Antibodies  >72 publications with HLA-G and Adenocarcinoma
 Skin Diseases Antibodies  >53 publications with HLA-G and Skin Diseases
 Neuroectodermal Tumors Antibodies  >49 publications with HLA-G and Neuroectodermal Tumors
 Leukemia Antibodies  >49 publications with HLA-G and Leukemia
 Melanoma Antibodies  >44 publications with HLA-G and Melanoma
 Inflammation Antibodies  >42 publications with HLA-G and Inflammation
 Nervous System Diseases Antibodies  >31 publications with HLA-G and Nervous System Diseases
 Lung Diseases Antibodies  >26 publications with HLA-G and Lung Diseases

Organs/Tissues associated with anti-HLA-G antibody

 Organ/Tissue Name  Pubmed Publications
 Placenta Antibodies  >388 publications with HLA-G and Placenta
 Embryonic Tissue Antibodies  >167 publications with HLA-G and Embryonic Tissue
 Thymus Antibodies  >22 publications with HLA-G and Thymus
 Brain Antibodies  >22 publications with HLA-G and Brain
 Lung Antibodies  >21 publications with HLA-G and Lung
 Stomach Antibodies  >6 publications with HLA-G and Stomach
 Intestine Antibodies  >6 publications with HLA-G and Intestine
 Testis Antibodies  >4 publications with HLA-G and Testis
 Pancreas Antibodies  >3 publications with HLA-G and Pancreas
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