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B3GAT3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6370838

The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the… More details

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Product Overview

Online Datasheet in PDF
Product Name
B3GAT3, Polyclonal Antibody
Full Product Name
B3GAT3 (Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3, Beta-1,3-glucuronyltransferase 3, Glucuronosyltransferase I, UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase) APC
Product Gene Name
anti-B3GAT3 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human B3GAT3.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
37,122 Da
OMIM
245600
3D Structure
ModBase 3D Structure for O94766
Immunogen
Full length human B3GAT3, aa1-335 (NP_036332.2).
Immunogen Sequence
MKLKLKNVFLAYFLVSIAGLLYALVQLGQPCDCLPPLRAAAEQLRQKDLRISQLQAELRRPPPAPAQPPEPEALPTIYVVTPTYARLVQKAELVRLSQTLSLVPRLHWLLVEDAEGPTPLVSGLLAASGLLFTHLVVLTPKAQRLREGEPGWVHPRGVEQRNKALDWLRGRGGAVGGEKDPPPPGTQGVVYFADDDNTYSRELFEEMRWTRGVSVWPVGLVGGLRFEGPQVQDGRVVGFHTAWEPSRPFPVDMAGFAVALPLLLDKPNAQFDSTAPRGHLESSLLSHLVDPKDLEPRAANCTRVLVWHTRTEKPKMKQEEQLQRQGRGSDPAIEV
Conjugate
APC
Note
Preservative Free

Product Categories/Family for anti-B3GAT3 antibody

Antibodies; Enzymes; Glucuronosyltransferase
Applications Tested/Suitable for anti-B3GAT3 antibody
Western Blot (WB)
Application Notes for anti-B3GAT3 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-B3GAT3 antibody

Western Blot analysis of B3GAT3 expression in transfected 293T cell line by B3GAT3 polyclonal antibody. Lane 1: B3GAT3 transfected lysate (37.1kD). Lane 2: Non-transfected lysate.
Rabbit Anti-B3GAT3 Polyclonal Antibody – Cat# MBS6370838

Other Notes

Small volumes of anti-B3GAT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for B3GAT3 purchase

MBS6370838 is an antibody targeting B3GAT3. Also known as B3GAT3 (Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3, Beta-1,3-glucuronyltransferase 3, Glucuronosyltransferase I, UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase) APC. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for B3GAT3. It may not necessarily be applicable to this product.

NCBI GI #
12408654
NCBI GeneID
26229
NCBI Accession #
NP_036332.2
UniProt Primary Accession #
O94766
UniProt Secondary Accession #
Q96I06; Q9UEP0
UniProt Related Accession #
O94766
GenBank Nucleotide #
NM_012200.2
NCBI Official Full Name
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 isoform 1
NCBI Official Synonym Full Names
beta-1,3-glucuronyltransferase 3
NCBI Official Symbol
B3GAT3
NCBI Official Synonym Symbols
GLCATI; glcUAT-I
UniProt Protein Name
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3
UniProt Synonym Protein Names
Beta-1,3-glucuronyltransferase 3; Glucuronosyltransferase I; GlcAT-I; UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase; GlcUAT-I
Protein Family
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase
UniProt Gene Name
B3GAT3
UniProt Synonym Gene Names
GlcAT-I; GlcUAT-I
UniProt Entry Name
B3GA3_HUMAN
NCBI Protein Information
galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3; Sqv-8-like protein; UDP-GlcUA:Gal beta-1,3-Gal-R glucuronyltransferase; beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)

UniProt Comments for B3GAT3

B3GAT3: Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc. Defects in B3GAT3 are the cause of multiple joint dislocations short stature craniofacial dysmorphism and congenital heart defects (JDSSDHD). An autosomal recessive disease characterized by dysmorphic facies, bilateral dislocations of the elbows, hips, and knees, clubfeet, and short stature, as well as cardiovascular defects. Belongs to the glycosyltransferase 43 family.

Protein type: Glycan Metabolism - heparan sulfate biosynthesis; Transferase; EC 2.4.1.135; Membrane protein, integral; Glycan Metabolism - chondroitin sulfate biosynthesis

Chromosomal Location of Human Ortholog: 11q12.3

Cellular Component: Golgi membrane; Golgi apparatus; cis-Golgi network; membrane; integral to membrane

Molecular Function: protein binding; glucuronosyltransferase activity; metal ion binding; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity

Biological Process: chondroitin sulfate metabolic process; positive regulation of catalytic activity; glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; heparan sulfate proteoglycan biosynthetic process; chondroitin sulfate proteoglycan biosynthetic process; carbohydrate metabolic process; protein amino acid glycosylation; pathogenesis; dermatan sulfate proteoglycan biosynthetic process

Disease: Multiple Joint Dislocations, Short Stature, Craniofacial Dysmorphism, And Congenital Heart Defects
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-B3GAT3 antibody

 Reference Product  PubMed Publications
 B4GALT7 antibody  >2 publications with B3GAT3 and B4GALT7
 EXTL3 antibody  >1 publications with B3GAT3 and EXTL3
 CSGALNACT1 antibody  >1 publications with B3GAT3 and CSGALNACT1
 CSGALNACT2 antibody  >1 publications with B3GAT3 and CSGALNACT2

Pathways associated with anti-B3GAT3 antibody

 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram
 Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway Diagram
 Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway antibodies  Glycosaminoglycan Biosynthesis - Chondroitin Sulfate / Dermatan Sulfate Pathway Diagram
 Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway antibodies  Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway Diagram
 Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway antibodies  Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway Diagram
 Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway antibodies  Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway Diagram
 Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway antibodies  Glycosaminoglycan Biosynthesis, Linkage Tetrasaccharide Pathway Diagram

Diseases associated with anti-B3GAT3 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >2 publications with B3GAT3 and Congenital Abnormalities

Organs/Tissues associated with anti-B3GAT3 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >2 publications with B3GAT3 and Bone
 Connective Tissue Antibodies  >2 publications with B3GAT3 and Connective Tissue
 Heart Antibodies  >1 publications with B3GAT3 and Heart
 Skin Antibodies  >1 publications with B3GAT3 and Skin
 Embryonic Tissue Antibodies  >1 publications with B3GAT3 and Embryonic Tissue
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