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BACH1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS614831

BRCA1 interacts in vivo with a novel protein, BACH1, a member of the DEAH helicase family. Mutations in BACH1 interfere with normal double-strand break repair in a manner that is dependent on its BRCA1 binding function. More details

$450 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BACH1, Polyclonal Antibody
Full Product Name
BACH1
Product Gene Name
anti-BACH1 antibody
Product Synonym Names
Anti -BACH1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide before the addition of 40% glycerol.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Reacts with residues 1233-1249 NFKPSPSKNKGMFPGFK of the human BACH1 protein.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (30-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
81,958 Da
Chromosome Location
chromosome: 21; Location: 21q22.11
OMIM
602751
3D Structure
ModBase 3D Structure for O14867
Immunogen
Synthetic peptide, aa1233-1249[ NFKPSPSKNKGMFPGFK] of the human BACH1 protein.

Product Categories/Family for anti-BACH1 antibody

Antibodies; Abs to Enzymes
Applications Tested/Suitable for anti-BACH1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-BACH1 antibody
Suitable for use in Western Blot and ELISA.
Dilution: Western Blot: 1:250-1:500

Other Notes

Small volumes of anti-BACH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BACH1 purchase

MBS614831 is an antibody targeting BACH1. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BACH1. It may not necessarily be applicable to this product.

NCBI GI #
2911116
NCBI GeneID
571
UniProt Primary Accession #
O14867
UniProt Secondary Accession #
O43285
UniProt Related Accession #
O14867; Q6ICU0; Q9BXM4
NCBI Official Full Name
BACH1
NCBI Official Synonym Full Names
BTB and CNC homology 1, basic leucine zipper transcription factor 1
NCBI Official Symbol
BACH1
NCBI Official Synonym Symbols
BACH-1; BACH1
UniProt Protein Name
Transcription regulator protein BACH1
UniProt Synonym Protein Names
BTB and CNC homolog 1; HA2303
Protein Family
Transcription regulator protein
UniProt Gene Name
BACH1
UniProt Entry Name
BACH1_HUMAN
NCBI Protein Information
transcription regulator protein BACH1; HA2303; BTB and CNC homolog 1; basic region leucine zipper transcriptional regulator BACH1

NCBI Summary for BACH1

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq]
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UniProt Comments for BACH1

BACH1: a transcriptional regulator that acts as a repressor or activator. Binds, in-vitro, to NF-E2 binding sites on DNA. Plays an important role in coordinating transcription activation and repression by NF-E2. Belongs to the bZIP family, CNC subfamily.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: nucleoplasm; cytoplasm; nucleus; cytosol

Molecular Function: heme binding; transcription factor activity

Biological Process: G1/S-specific transcription in mitotic cell cycle; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; G2/M-specific transcription in mitotic cell cycle
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Research Articles on BACH1

1. prevents radiation-induced upregulation of heme oxygenase 1 gene expression in keratinocytes
2. miR-196 directly acts on the 3'-UTR of Bach1 messenger RNA and translationally represses the expression of this protein.
3. The interaction between TopBP1 and BACH1 is required for the extension of single-stranded DNA regions and RPA loading following replication stress, which is a prerequisite for the subsequent activation of replication checkpoint.
4. ERK(1/2) and JNK are involved in cigarette smoking-induced biphasic HO-1 expression by a specific regulation of Nrf2/Keap1-Bach1.
5. regulates oxidative stress response in cellular senescence. (review)
6. Bach1 inhibits expression of oxidative stress responsive genes by competing with Nrf2, the key activator of oxidative stress response. Bach1 inhibits p53-dependent cellular senescence induced by oxidative stress
7. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
8. Loss of BACH1 function in human keratinocytes results almost exclusively in HMOX1 induction
9. BACH-1 protein levels are low in cells expressing either the human miR-155 or miR-K12-11 of Kaposi's sarcoma-associated herpesvirus.
10. These results indicated that heme plays an important role in the induction of alpha-globin gene expression through disrupting the interaction of Bach1 and the NA site in HS-40 enhancer in erythroid cells.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BACH1 antibody

 Reference Product  PubMed Publications
 MAFK antibody  >14 publications with BACH1 and MAFK

Diseases associated with anti-BACH1 antibody

 Disease Name  Pubmed Publications
 Anemia Antibodies  >123 publications with BACH1 and Anemia
 Neoplasms Antibodies  >56 publications with BACH1 and Neoplasms
 Breast Neoplasms Antibodies  >32 publications with BACH1 and Breast Neoplasms
 Skin Diseases Antibodies  >32 publications with BACH1 and Skin Diseases
 Leukemia Antibodies  >13 publications with BACH1 and Leukemia
 Ovarian Neoplasms Antibodies  >11 publications with BACH1 and Ovarian Neoplasms
 Carcinoma Antibodies  >11 publications with BACH1 and Carcinoma
 Congenital Abnormalities Antibodies  >10 publications with BACH1 and Congenital Abnormalities
 Nervous System Diseases Antibodies  >9 publications with BACH1 and Nervous System Diseases
 Leukemia, Myeloid, Acute Antibodies  >8 publications with BACH1 and Leukemia, Myeloid, Acute

Organs/Tissues associated with anti-BACH1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with BACH1 and Blood
 Liver Antibodies  >12 publications with BACH1 and Liver
 Vascular Antibodies  >8 publications with BACH1 and Vascular
 Bone Antibodies  >7 publications with BACH1 and Bone
 Lung Antibodies  >6 publications with BACH1 and Lung
 Muscle Antibodies  >5 publications with BACH1 and Muscle
 Brain Antibodies  >5 publications with BACH1 and Brain
 Skin Antibodies  >3 publications with BACH1 and Skin
 Intestine Antibodies  >2 publications with BACH1 and Intestine
 Testis Antibodies  >2 publications with BACH1 and Testis
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