Rabbit Anti-BAG5 Polyclonal Antibody – Cat# MBS6277556

BAG5 Antibody – Rabbit Polyclonal

Name: BAG5 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6277556
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6277556

BAG5 is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth… More details

$1060 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BAG5, Polyclonal Antibody

Full Product Name

BAG5, NT (BAG5, KIAA0873, BAG family molecular chaperone regulator 5, Bcl-2-associated athanogene 5) (MaxLight 650)

Product Gene Name

anti-BAG5 antibody

Product Synonym Names

BAG5; KIAA0873; BAG family molecular chaperone regulator 5; Bcl-2-associated athanogene 5

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

56,027 Da

OMIM

603885

3D Structure

ModBase 3D Structure for Q9UL15

Immunogen

BAG5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-50 amino acids from the N-terminal region of human BAG5.

Conjugate

MaxLight650

Note

Preservative Free

Product Categories/Family for anti-BAG5 antibody

Antibodies; KIAA; orf

Applications Tested/Suitable for anti-BAG5 antibody

Western Blot (WB), FLISA

Application Notes for anti-BAG5 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-BAG5 antibody

Bailey, S.D., et al. Diabetes Care (2010). In press: Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Kalia, S.K., et al. Neuron 44(6):931-945(2004). Takayama, S., et al. J. Biol. Chem. 274(2):781-786(1999). Hohfeld, J., et al. EMBO J. 16(20):6209-6216(1997).

Other Notes

Small volumes of anti-BAG5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BAG5 purchase

MBS6277556 is an antibody targeting BAG5. Also known as BAG5, NT (BAG5, KIAA0873, BAG family molecular chaperone regulator 5, Bcl-2-associated athanogene 5) (MaxLight 650). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BAG5. It may not necessarily be applicable to this product.

NCBI GI #

62548854

NCBI GeneID

9529

NCBI Accession #

NP_001015048.1

NCBI Related Accession #

NP_004864.1

UniProt Primary Accession #

Q9UL15

UniProt Secondary Accession #

O94950; Q86W59

UniProt Related Accession #

Q9UL15

GenBank Nucleotide #

NM_001015048.2

NCBI Official Full Name

BAG family molecular chaperone regulator 5 isoform b

NCBI Official Synonym Full Names

BCL2-associated athanogene 5

NCBI Official Symbol

BAG5

NCBI Official Synonym Symbols

BAG-5

UniProt Protein Name

BAG family molecular chaperone regulator 5

UniProt Synonym Protein Names

Bcl-2-associated athanogene 5

Protein Family

BAG family molecular chaperone regulator

UniProt Gene Name

BAG5

UniProt Synonym Gene Names

KIAA0873; BAG-5

UniProt Entry Name

BAG5_HUMAN

NCBI Protein Information

BAG family molecular chaperone regulator 5; bcl-2-associated athanogene 5; BAG-family molecular chaperone regulator-5

NCBI Summary for BAG5

The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for BAG5

BAG5: Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2. May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: membrane; mitochondrion; perinuclear region of cytoplasm; inclusion body; nucleus

Molecular Function: protein binding; chaperone binding; ubiquitin protein ligase binding; protein kinase binding

Biological Process: protein folding; negative regulation of ubiquitin-protein ligase activity; negative regulation of protein ubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process

Research Articles on BAG5

1. BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BAG5 antibody

Reference Product	PubMed Publications
PARK2 antibody	>6 publications with BAG5 and PARK2
BAG1 antibody	>5 publications with BAG5 and BAG1
BAG2 antibody	>2 publications with BAG5 and BAG2
HSPA8 antibody	>2 publications with BAG5 and HSPA8
STUB1 antibody	>1 publications with BAG5 and STUB1

Diseases associated with anti-BAG5 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>6 publications with BAG5 and Nervous System Diseases
Necrosis Antibodies	>3 publications with BAG5 and Necrosis
Breast Neoplasms Antibodies	>2 publications with BAG5 and Breast Neoplasms
Nerve Degeneration Antibodies	>2 publications with BAG5 and Nerve Degeneration
Prostatic Neoplasms Antibodies	>1 publications with BAG5 and Prostatic Neoplasms
Inflammation Antibodies	>1 publications with BAG5 and Inflammation

Organs/Tissues associated with anti-BAG5 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>6 publications with BAG5 and Brain
Blood Antibodies	>2 publications with BAG5 and Blood
Bone Antibodies	>1 publications with BAG5 and Bone
Ganglia Antibodies	>1 publications with BAG5 and Ganglia
Heart Antibodies	>1 publications with BAG5 and Heart
Lung Antibodies	>1 publications with BAG5 and Lung
Prostate Antibodies	>1 publications with BAG5 and Prostate
Kidney Antibodies	>1 publications with BAG5 and Kidney
Eye Antibodies	>1 publications with BAG5 and Eye
Liver Antibodies	>1 publications with BAG5 and Liver