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BBC3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6454429

MBS6454429 is an antibody targeting BBC3. Also known as BBC3 (Bcl-2-Binding Component 3, JFY-1, p53 Up-Regulated Modulator of Apoptosis, BBC3, PUMA) (MaxLight 405). Reactive in Human. Host: Rabbit. More details

$1025 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BBC3, Polyclonal Antibody
Full Product Name
BBC3 (Bcl-2-Binding Component 3, JFY-1, p53 Up-Regulated Modulator of Apoptosis, BBC3, PUMA) (MaxLight 405)
Product Gene Name
anti-BBC3 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human BBC3. Species Crossreactivity: human
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
23 kDa
OMIM
605854
3D Structure
ModBase 3D Structure for Q96PG8
Immunogen
KLH conjugated synthetic peptide corresponding to aa158-192 from human BBC3.
Conjugate
MaxLight405
Note
Preservative Free

Product Categories/Family for anti-BBC3 antibody

Antibodies; Apoptosis
Applications Tested/Suitable for anti-BBC3 antibody
Western Blot (WB)
Application Notes for anti-BBC3 antibody
WB: 1:2000
Applications are based on unconjugated antibody.

Product References and Citations for anti-BBC3 antibody

Nakano K., et al. Mol. Cell 7:683-694(2001). Grimwood J., et al. Nature 428:529-535(2004). Mural R.J., et al. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

Other Notes

Small volumes of anti-BBC3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BBC3. It may not necessarily be applicable to this product.

NCBI GI #
15193488
NCBI GeneID
27113
NCBI Accession #
NP_055232
UniProt Primary Accession #
Q96PG8
UniProt Secondary Accession #
O00171; Q96PG9; B9EGI3
UniProt Related Accession #
Q96PG8; Q9BXH1
GenBank Nucleotide #
NM_014417.4
NCBI Official Full Name
bcl-2-binding component 3 isoform 4
NCBI Official Synonym Full Names
BCL2 binding component 3
NCBI Official Symbol
BBC3
NCBI Official Synonym Symbols
JFY1; PUMA; JFY-1
UniProt Protein Name
Bcl-2-binding component 3
UniProt Synonym Protein Names
JFY-1; p53 up-regulated modulator of apoptosis
Protein Family
Bcl-2-binding component
UniProt Gene Name
BBC3
UniProt Synonym Gene Names
PUMA
UniProt Entry Name
BBC3_HUMAN
NCBI Protein Information
bcl-2-binding component 3; p53 up-regulated modulator of apoptosis

NCBI Summary for BBC3

This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
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UniProt Comments for BBC3

BBC3B: Essential mediator of p53/TP53-dependent and p53/TP53- independent apoptosis. Isoform 3 fails to show any growth- inhibitory or apoptotic activity. Induced by DNA damage, glucocorticoid treatment, growth factor deprivation and p53/TP53. {ECO:0000269|PubMed:11463392}. Isoform 3 does not interact with BCL2. 4 isoforms of the human protein are produced by alternative splicing

Protein type: Apoptosis; Mitochondrial

Chromosomal Location of Human Ortholog: 19q13.3-q13.4

Cellular Component: mitochondrial outer membrane; mitochondrion; cytosol

Molecular Function: protein binding

Biological Process: caspase activation; release of cytochrome c from mitochondria; positive regulation of protein homooligomerization; apoptosis; positive regulation of neuron apoptosis; release of sequestered calcium ion into cytosol; reduction of endoplasmic reticulum calcium ion concentration; determination of adult life span; response to DNA damage stimulus; negative regulation of growth
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Research Articles on BBC3

1. c-Jun transactivates Puma gene expression to promote osteoarthritis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-BBC3 antibody

 Products by Pathway  Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Activation Of PUMA And Translocation To Mitochondria Pathway antibodies  Activation Of PUMA And Translocation To Mitochondria Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway antibodies  BH3-only Proteins Associate With And Inactivate Anti-apoptotic BCL-2 Members Pathway Diagram
 DNA Damage Response Pathway antibodies  DNA Damage Response Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram

Diseases associated with anti-BBC3 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >73 publications with BBC3 and Carcinoma
 Adenocarcinoma Antibodies  >33 publications with BBC3 and Adenocarcinoma
 Breast Neoplasms Antibodies  >32 publications with BBC3 and Breast Neoplasms
 Lung Neoplasms Antibodies  >24 publications with BBC3 and Lung Neoplasms
 Necrosis Antibodies  >20 publications with BBC3 and Necrosis
 Liver Diseases Antibodies  >18 publications with BBC3 and Liver Diseases
 Lung Diseases Antibodies  >17 publications with BBC3 and Lung Diseases
 Nervous System Diseases Antibodies  >16 publications with BBC3 and Nervous System Diseases
 Carcinoma, Squamous Cell Antibodies  >13 publications with BBC3 and Carcinoma, Squamous Cell
 Brain Diseases Antibodies  >13 publications with BBC3 and Brain Diseases

Organs/Tissues associated with anti-BBC3 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >30 publications with BBC3 and Lung
 Brain Antibodies  >18 publications with BBC3 and Brain
 Kidney Antibodies  >13 publications with BBC3 and Kidney
 Skin Antibodies  >12 publications with BBC3 and Skin
 Prostate Antibodies  >12 publications with BBC3 and Prostate
 Stomach Antibodies  >12 publications with BBC3 and Stomach
 Muscle Antibodies  >9 publications with BBC3 and Muscle
 Bone Antibodies  >9 publications with BBC3 and Bone
 Eye Antibodies  >7 publications with BBC3 and Eye
 Intestine Antibodies  >6 publications with BBC3 and Intestine
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