BBS10 Antibody – Rabbit Polyclonal

BBS10 is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes.

Marion, V., et al. Proc. Natl. Acad. Sci. U.S.A. 106(6):1820-1825(2009). Gerth, C., et al. Vision Res. 48(3):392-399(2008). White, D.R., et al. Eur. J. Hum. Genet. 15(2):173-178(2007).

Small volumes of anti-BBS10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6277728 is an antibody targeting BBS10. Also known as BBS10, CT (BBS10, C12orf58, Bardet-Biedl syndrome 10 protein) (Azide free) (HRP). Reactive in Human. Host: Rabbit.