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BCAN Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3222395

This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix.… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BCAN, Polyclonal Antibody
Full Product Name
BCAN Antibody - middle region
Product Gene Name
anti-BCAN antibody
Product Synonym Gene Name
BEHAB; CSPG7
Immunogen Sequence
Synthetic peptide located within the following region: ESLSQAPARA VLQPGASPLP DGESEASRPP RVHGPPTETL PTPRERNLAS
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Purity/Purification
Affinity purified
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
BCAN peptide (MBS3247068) is used for blocking the activity of BCAN antibody (MBS3222395)
Molecular Weight
73 kDa
OMIM
600347
3D Structure
ModBase 3D Structure for Q96GW7
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human BCAN

Product Categories/Family for anti-BCAN antibody

Polyclonal; Cancer; Neurobiology; Cell Biology
Applications Tested/Suitable for anti-BCAN antibody
Western Blot (WB)

Western Blot (WB) of anti-BCAN antibody

Host: Rabbit
Target Name: BCAN
Sample Tissue: Human HCT15 Whole Cell lysates
Antibody Dilution: 1ug/ml
Rabbit Anti-BCAN Polyclonal Antibody – Cat# MBS3222395

Other Notes

Small volumes of anti-BCAN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BCAN purchase

MBS3222395 is an antibody targeting BCAN. Also known as BCAN Antibody - middle region. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BCAN. It may not necessarily be applicable to this product.

NCBI GI #
38372935
NCBI GeneID
63827
NCBI Accession #
NP_068767.3
UniProt Primary Accession #
Q96GW7
UniProt Related Accession #
Q96GW7
GenBank Nucleotide #
NM_021948.4
NCBI Official Full Name
brevican core protein isoform 1
NCBI Official Synonym Full Names
brevican
NCBI Official Symbol
BCAN
NCBI Official Synonym Symbols
BEHAB; CSPG7
UniProt Protein Name
Brevican core protein
UniProt Synonym Protein Names
Brain-enriched hyaluronan-binding protein; BEHAB; Chondroitin sulfate proteoglycan 7
Protein Family
Brevican core protein
UniProt Gene Name
BCAN
UniProt Synonym Gene Names
BEHAB; CSPG7; BEHAB
UniProt Entry Name
PGCB_HUMAN
NCBI Protein Information
brevican core protein

UniProt Comments for BCAN

BCAN: May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Belongs to the aggrecan/versican proteoglycan family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Membrane protein, GPI anchor; Secreted

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: proteinaceous extracellular matrix; lysosomal lumen; Golgi lumen; extracellular region

Molecular Function: extracellular matrix structural constituent; hyaluronic acid binding; carbohydrate binding

Biological Process: chondroitin sulfate metabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; chondroitin sulfate biosynthetic process; central nervous system development; glycosaminoglycan metabolic process; chondroitin sulfate catabolic process; hippocampus development; carbohydrate metabolic process; pathogenesis; cell adhesion; skeletal development; dermatan sulfate biosynthetic process
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Research Articles on BCAN

1. Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BCAN antibody

 Reference Product  PubMed Publications
 NCAN antibody  >24 publications with BCAN and NCAN
 VCAN antibody  >18 publications with BCAN and VCAN
 DCN antibody  >4 publications with BCAN and DCN
 BGN antibody  >1 publications with BCAN and BGN

Pathways associated with anti-BCAN antibody

 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 CS/DS Degradation Pathway antibodies  CS/DS Degradation Pathway Diagram
 Chondroitin Sulfate Biosynthesis Pathway antibodies  Chondroitin Sulfate Biosynthesis Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Dermatan Sulfate Biosynthesis Pathway antibodies  Dermatan Sulfate Biosynthesis Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram

Diseases associated with anti-BCAN antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >51 publications with BCAN and Nervous System Diseases
 Neoplasms Antibodies  >43 publications with BCAN and Neoplasms
 Disease Models, Animal Antibodies  >16 publications with BCAN and Disease Models, Animal
 Spinal Cord Diseases Antibodies  >14 publications with BCAN and Spinal Cord Diseases
 Urinary Bladder Neoplasms Antibodies  >8 publications with BCAN and Urinary Bladder Neoplasms
 Inflammation Antibodies  >7 publications with BCAN and Inflammation
 Lung Neoplasms Antibodies  >3 publications with BCAN and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >3 publications with BCAN and Neoplasms, Experimental
 Lung Diseases Antibodies  >3 publications with BCAN and Lung Diseases
 Breast Neoplasms Antibodies  >3 publications with BCAN and Breast Neoplasms

Organs/Tissues associated with anti-BCAN antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >120 publications with BCAN and Brain
 Embryonic Tissue Antibodies  >12 publications with BCAN and Embryonic Tissue
 Skin Antibodies  >4 publications with BCAN and Skin
 Uterus Antibodies  >1 publications with BCAN and Uterus
 Kidney Antibodies  >1 publications with BCAN and Kidney
 Eye Antibodies  >1 publications with BCAN and Eye
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