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BCAN Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6277761

Brevican core protein may play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BCAN, Polyclonal Antibody
Full Product Name
BCAN, CT (BCAN, BEHAB, CSPG7, Brevican core protein, Brain-enriched hyaluronan-binding protein, Chondroitin sulfate proteoglycan 7) (Azide free) (HRP)
Product Gene Name
anti-BCAN antibody
Product Synonym Names
BCAN; BEHAB; CSPG7; Brevican core protein; Brain-enriched hyaluronan-binding protein; Chondroitin sulfate proteoglycan 7
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human BCAN.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
99,118 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (156611740..156629324). Location: 1q31
OMIM
600347
3D Structure
ModBase 3D Structure for Q96GW7
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 715-741 in the C-terminal region of human BCAN, UniProt Accession #NP_940819.1; Q96GW7. Species sequence homology: bovine
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-BCAN antibody

Antibodies; Carbohydrates; Glycoproteins
Applications Tested/Suitable for anti-BCAN antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-BCAN antibody
IHC: 1:50-100
ELISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-BCAN antibody

Western Blot analysis in CEM cell line lysates (35ug/lane) usingMBS642278. This demonstrates that MBS642278 detected the BCAN protein (arrow).
Rabbit Anti-BCAN Polyclonal Antibody – Cat# MBS6277761

Immunohistochemistry (IHC) of anti-BCAN antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue using MBS642278 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS642278 for immunohistochemistry.
Rabbit Anti-BCAN Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6277761

Other Notes

Small volumes of anti-BCAN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BCAN purchase

MBS6277761 is an antibody targeting BCAN. Also known as BCAN, CT (BCAN, BEHAB, CSPG7, Brevican core protein, Brain-enriched hyaluronan-binding protein, Chondroitin sulfate proteoglycan 7) (Azide free) (HRP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BCAN. It may not necessarily be applicable to this product.

NCBI GI #
38372931
NCBI GeneID
63827
NCBI Accession #
NP_940819.1
NCBI Related Accession #
NP_068767.3
UniProt Primary Accession #
Q96GW7
UniProt Secondary Accession #
Q28062
UniProt Related Accession #
Q96GW7
GenBank Nucleotide #
NM_198427.1
NCBI Official Full Name
brevican core protein isoform 2
NCBI Official Synonym Full Names
brevican
NCBI Official Symbol
BCAN
NCBI Official Synonym Symbols
BEHAB; CSPG7
UniProt Protein Name
Brevican core protein
UniProt Synonym Protein Names
Brain-enriched hyaluronan-binding protein; BEHAB; Chondroitin sulfate proteoglycan 7
Protein Family
Brevican core protein
UniProt Gene Name
BCAN
UniProt Synonym Gene Names
BEHAB; CSPG7; BEHAB
UniProt Entry Name
PGCB_HUMAN
NCBI Protein Information
brevican core protein; chondroitin sulfate proteoglycan 7; chondroitin sulfate proteoglycan BEHAB; brain-enriched hyaluronan-binding protein

NCBI Summary for BCAN

This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
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UniProt Comments for BCAN

BCAN: May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans. Belongs to the aggrecan/versican proteoglycan family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Membrane protein, GPI anchor; Secreted

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: proteinaceous extracellular matrix; lysosomal lumen; Golgi lumen; extracellular region

Molecular Function: extracellular matrix structural constituent; hyaluronic acid binding; carbohydrate binding

Biological Process: chondroitin sulfate metabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; chondroitin sulfate biosynthetic process; central nervous system development; glycosaminoglycan metabolic process; chondroitin sulfate catabolic process; hippocampus development; carbohydrate metabolic process; pathogenesis; cell adhesion; skeletal development; dermatan sulfate biosynthetic process
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Research Articles on BCAN

1. Data indicate that median methylation levels of BCAN, HOXD1, KCTD8, KLF11, NXPH1, POU4F1, SIM1, and TCF7L1 were >/=30% higher than in normal samples, representing potential biomarkers for tumor diagnosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BCAN antibody

 Reference Product  PubMed Publications
 NCAN antibody  >22 publications with BCAN and NCAN
 VCAN antibody  >12 publications with BCAN and VCAN
 DCN antibody  >2 publications with BCAN and DCN
 BGN antibody  >1 publications with BCAN and BGN

Pathways associated with anti-BCAN antibody

 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 CS/DS Degradation Pathway antibodies  CS/DS Degradation Pathway Diagram
 Chondroitin Sulfate Biosynthesis Pathway antibodies  Chondroitin Sulfate Biosynthesis Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Dermatan Sulfate Biosynthesis Pathway antibodies  Dermatan Sulfate Biosynthesis Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway antibodies  Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway Diagram

Diseases associated with anti-BCAN antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >33 publications with BCAN and Neoplasms
 Nervous System Diseases Antibodies  >25 publications with BCAN and Nervous System Diseases
 Urinary Bladder Neoplasms Antibodies  >7 publications with BCAN and Urinary Bladder Neoplasms
 Disease Models, Animal Antibodies  >5 publications with BCAN and Disease Models, Animal
 Spinal Cord Diseases Antibodies  >4 publications with BCAN and Spinal Cord Diseases
 Skin Diseases Antibodies  >4 publications with BCAN and Skin Diseases
 Neoplasms, Experimental Antibodies  >3 publications with BCAN and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >3 publications with BCAN and Cardiovascular Diseases
 Inflammation Antibodies  >3 publications with BCAN and Inflammation
 Lung Neoplasms Antibodies  >2 publications with BCAN and Lung Neoplasms

Organs/Tissues associated with anti-BCAN antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >61 publications with BCAN and Brain
 Embryonic Tissue Antibodies  >6 publications with BCAN and Embryonic Tissue
 Skin Antibodies  >2 publications with BCAN and Skin
 Kidney Antibodies  >1 publications with BCAN and Kidney
 Eye Antibodies  >1 publications with BCAN and Eye
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