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BGLAP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6278309

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BGLAP, Polyclonal Antibody
Full Product Name
BGLAP, CT (C80) (BGLAP, Osteocalcin, Bone Gla protein, Gamma-carboxyglutamic acid-containing protein) (Biotin)
Product Gene Name
anti-BGLAP antibody
Product Synonym Names
BGLAP; Osteocalcin; Bone Gla protein; Gamma-carboxyglutamic acid-containing protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
10,963 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (156211951..156213123). Location: 1q22
OMIM
112260
3D Structure
ModBase 3D Structure for P02818
Immunogen
BGLAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-100 amino acids from the C-terminal region of human BGLAP.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-BGLAP antibody

Antibodies; Osteocalcin
Applications Tested/Suitable for anti-BGLAP antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-BGLAP antibody
WB: 1:50-100
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-BGLAP antibody

BGLAP Antibody (C80) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the BGLAP antibody detected the BGLAP protein (arrow).
Rabbit Anti-BGLAP Polyclonal Antibody – Cat# MBS6278309

Product References and Citations for anti-BGLAP antibody

Yeap, B.B., et al. Eur. J. Endocrinol. 163(2):265-272(2010). Lee, Y.J., et al. Diabetes Care 33 (7), E90 (2010): Foresta, C., et al. J. Clin. Endocrinol. Metab. 95(7):3502-3506(2010). Saleem, U., et al. Arterioscler. Thromb. Vasc. Biol. 30(7):1474-1478(2010). Das, S.K., et al. Dis. Markers 28(5):281-286(2010).

Other Notes

Small volumes of anti-BGLAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BGLAP purchase

MBS6278309 is an antibody targeting BGLAP. Also known as BGLAP, CT (C80) (BGLAP, Osteocalcin, Bone Gla protein, Gamma-carboxyglutamic acid-containing protein) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BGLAP. It may not necessarily be applicable to this product.

NCBI GI #
40316933
NCBI GeneID
632
NCBI Accession #
NP_954642.1
UniProt Primary Accession #
P02818
UniProt Secondary Accession #
Q5TCK6
UniProt Related Accession #
P02818
GenBank Nucleotide #
NM_199173.4
NCBI Official Full Name
osteocalcin preproprotein
NCBI Official Synonym Full Names
bone gamma-carboxyglutamate (gla) protein
NCBI Official Symbol
BGLAP
NCBI Official Synonym Symbols
OC; BGP; OCN
UniProt Protein Name
Osteocalcin
UniProt Synonym Protein Names
Bone Gla protein; BGP; Gamma-carboxyglutamic acid-containing protein
Protein Family
Osteocalcin
UniProt Gene Name
BGLAP
UniProt Synonym Gene Names
BGP
UniProt Entry Name
OSTCN_HUMAN
NCBI Protein Information
osteocalcin; bone Gla protein; gamma-carboxyglutamic acid-containing protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin)

NCBI Summary for BGLAP

This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
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UniProt Comments for BGLAP

osteocalcin: Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. Belongs to the osteocalcin/matrix Gla protein family.

Protein type: Secreted, signal peptide; Secreted; Cell development/differentiation

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: Golgi apparatus; extracellular space; rough endoplasmic reticulum; dendrite; cytoplasm; perikaryon

Molecular Function: structural constituent of bone; hydroxyapatite binding; calcium ion binding; structural molecule activity

Biological Process: response to drug; response to gravity; regulation of bone resorption; response to glucocorticoid stimulus; cell aging; response to testosterone stimulus; bone mineralization; osteoblast development; odontogenesis; osteoblast differentiation; regulation of osteoclast differentiation; response to ethanol; response to vitamin D; response to vitamin K; response to estrogen stimulus; response to mechanical stimulus; response to zinc ion; response to hydroxyisoflavone; response to activity; cell adhesion; regulation of bone mineralization; skeletal development
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Research Articles on BGLAP

1. Data suggest that serum level of total osteocalcin during the follicular phase is positively associated with fat-free mass in healthy premenopausal women.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BGLAP antibody

 Reference Product  PubMed Publications
 RUNX2 antibody  >27 publications with BGLAP and RUNX2
 BMP2 antibody  >9 publications with BGLAP and BMP2
 TGFB1 antibody  >3 publications with BGLAP and TGFB1
 VDR antibody  >3 publications with BGLAP and VDR
 LEP antibody  >1 publications with BGLAP and LEP
 PTHLH antibody  >1 publications with BGLAP and PTHLH
 PTH antibody  >1 publications with BGLAP and PTH
 ATF4 antibody  >1 publications with BGLAP and ATF4

Pathways associated with anti-BGLAP antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 Interleukin-11 Signaling Pathway antibodies  Interleukin-11 Signaling Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
 Mitotic Metaphase And Anaphase Pathway antibodies  Mitotic Metaphase And Anaphase Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram

Diseases associated with anti-BGLAP antibody

 Disease Name  Pubmed Publications
 Bone Diseases Antibodies  >8 publications with BGLAP and Bone Diseases
 Osteoporosis Antibodies  >5 publications with BGLAP and Osteoporosis
 Neoplasms Antibodies  >4 publications with BGLAP and Neoplasms
 Hemorrhage Antibodies  >1 publications with BGLAP and Hemorrhage
 Pain Antibodies  >1 publications with BGLAP and Pain
 Hypertension Antibodies  >1 publications with BGLAP and Hypertension
 Cardiovascular Diseases Antibodies  >1 publications with BGLAP and Cardiovascular Diseases
 Inflammation Antibodies  >1 publications with BGLAP and Inflammation
 Necrosis Antibodies  >1 publications with BGLAP and Necrosis
 Brain Injuries Antibodies  >1 publications with BGLAP and Brain Injuries

Organs/Tissues associated with anti-BGLAP antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >49 publications with BGLAP and Bone
 Brain Antibodies  >3 publications with BGLAP and Brain
 Parathyroid Antibodies  >1 publications with BGLAP and Parathyroid
 Prostate Antibodies  >1 publications with BGLAP and Prostate
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