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BIRC6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9231057

Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with… More details

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Product Overview

Online Datasheet in PDF
Product Name
BIRC6, Polyclonal Antibody
Full Product Name
BIRC6 Antibody (C-Term)
Product Gene Name
anti-BIRC6 antibody
Product Synonym Gene Name
KIAA1289
Product Synonym Names
Baculoviral IAP repeat-containing protein 6; 6.3.2.-; BIR repeat-containing ubiquitin-conjugating enzyme; BRUCE; Ubiquitin-conjugating BIR domain enzyme apollon; APOLLON; BIRC6; KIAA1289
Clonality
Polyclonal
Isotype
Ig
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Specificity
This BIRC6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 4810-4844 amino acids from human BIRC6.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Molecular Weight
530255 Da
OMIM
AC079837 Genomic DNA
3D Structure
ModBase 3D Structure for Q9NR09
Antigen Type
Synthesized Peptide
Antigen Source
Human
Cellular Location
Golgi apparatus, trans-Golgi network membrane. Midbody. Endosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis
Tissue Location
Expressed in brain cancer cells.

Product Categories/Family for anti-BIRC6 antibody

Primary Antibodies; Cell Biology
Applications Tested/Suitable for anti-BIRC6 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-BIRC6 antibody
WB: 1:1000

Western Blot (WB) of anti-BIRC6 antibody

All lanes : Anti-BIRC6 Antibody (C-Term) at 1:1000 dilution
Lane 1: SH-SY5Y whole cell lysate
Lane 2: Hela whole cell lysate


Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 530 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.
Rabbit Anti-BIRC6 Polyclonal Antibody – Cat# MBS9231057

Product References and Citations for anti-BIRC6 antibody

Hillier L.W.,et al.Nature 434:724-731 (2005). Chen Z.,et al.Biochem. Biophys. Res. Commun. 264:847-854 (1999). Nagase T.,et al.DNA Res. 6:337-345 (1999). Nakajima D.,et al.DNA Res. 9:99-106 (2002). Qiu X.B.,et al.EMBO J. 23:800-810 (2004).

Other Notes

Small volumes of anti-BIRC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BIRC6 purchase

MBS9231057 is an antibody targeting BIRC6. Also known as BIRC6 Antibody (C-Term). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BIRC6. It may not necessarily be applicable to this product.

NCBI GI #
153792694
NCBI GeneID
57448
NCBI Accession #
NP_057336.3
UniProt Primary Accession #
Q9NR09
UniProt Secondary Accession #
Q9ULD1
UniProt Related Accession #
Q9NR09
GenBank Nucleotide #
NM_016252.3
NCBI Official Full Name
baculoviral IAP repeat-containing protein 6
NCBI Official Synonym Full Names
baculoviral IAP repeat containing 6
NCBI Official Symbol
BIRC6
NCBI Official Synonym Symbols
BRUCE; APOLLON
UniProt Protein Name
Baculoviral IAP repeat-containing protein 6
UniProt Synonym Protein Names
BIR repeat-containing ubiquitin-conjugating enzyme; BRUCE; RING-type E3 ubiquitin transferase BIRC6Curated; Ubiquitin-conjugating BIR domain enzyme apollon; APOLLON
Protein Family
Baculoviral IAP repeat-containing protein
UniProt Gene Name
BIRC6
UniProt Synonym Gene Names
KIAA1289; BRUCE; APOLLON
NCBI Protein Information
baculoviral IAP repeat-containing protein 6

NCBI Summary for BIRC6

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]

UniProt Comments for BIRC6

BIRC6: Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Homodimer. Binds the activated, processed forms of CASP3, CASP6, CASP7 and CASP9. Interacts with RNF41, DIABLO/SMAC, HTRA2, KIF23/MKLP1, USP8/UBPY, BIRC5/survivin, MAP2K1/MEK1, RAB8A/RAB8, RAB11A/RAB11, PLK1, EXOC3/SEC6 and EXOC4/SEC8. Expressed in brain cancer cells. Inhibited by DIABLO/SMAC, HTRA2, CASP3, CASP6, CASP7 and CASP9.

Protein type: EC 6.3.2.-; EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 2p22.3

Cellular Component: endosome; membrane; microtubule organizing center; midbody; spindle pole; trans-Golgi network

Molecular Function: cysteine protease inhibitor activity; protein binding; ubiquitin-protein ligase activity

Biological Process: negative regulation of apoptosis; protein amino acid phosphorylation; protein ubiquitination; regulation of cell proliferation; regulation of cytokinesis
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Research Articles on BIRC6

1. Results show that in addition to the scaffolding function in complex formation, BRUCE has an E3 ligase function to promote BRIT1 deubiquitination by USP8 leading to accumulation of BRIT1 at DNA double-strand break.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BIRC6 antibody

 Reference Product  PubMed Publications
 CASP3 antibody  >12 publications with BIRC6 and CASP3
 CASP9 antibody  >10 publications with BIRC6 and CASP9
 DIABLO antibody  >7 publications with BIRC6 and DIABLO
 CASP7 antibody  >4 publications with BIRC6 and CASP7
 UBC antibody  >4 publications with BIRC6 and UBC
 RNF41 antibody  >3 publications with BIRC6 and RNF41
 HTRA2 antibody  >3 publications with BIRC6 and HTRA2
 USP8 antibody  >1 publications with BIRC6 and USP8

Pathways associated with anti-BIRC6 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram

Diseases associated with anti-BIRC6 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >6 publications with BIRC6 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >5 publications with BIRC6 and Neoplasms, Experimental
 Liver Diseases Antibodies  >3 publications with BIRC6 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with BIRC6 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >3 publications with BIRC6 and Liver Neoplasms
 Breast Neoplasms Antibodies  >2 publications with BIRC6 and Breast Neoplasms
 Fetal Death Antibodies  >2 publications with BIRC6 and Fetal Death
 Brain Diseases Antibodies  >2 publications with BIRC6 and Brain Diseases
 Ovarian Neoplasms Antibodies  >2 publications with BIRC6 and Ovarian Neoplasms
 Nervous System Diseases Antibodies  >2 publications with BIRC6 and Nervous System Diseases

Organs/Tissues associated with anti-BIRC6 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >4 publications with BIRC6 and Liver
 Placenta Antibodies  >4 publications with BIRC6 and Placenta
 Muscle Antibodies  >3 publications with BIRC6 and Muscle
 Heart Antibodies  >3 publications with BIRC6 and Heart
 Brain Antibodies  >3 publications with BIRC6 and Brain
 Lung Antibodies  >2 publications with BIRC6 and Lung
 Embryonic Tissue Antibodies  >2 publications with BIRC6 and Embryonic Tissue
 Skin Antibodies  >2 publications with BIRC6 and Skin
 Bone Marrow Antibodies  >2 publications with BIRC6 and Bone Marrow
 Bone Antibodies  >2 publications with BIRC6 and Bone
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