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BLIMP1 (PRDM1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6010086

This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus… More details

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Product Overview

Online Datasheet in PDF
Product Name
BLIMP1 (PRDM1), Polyclonal Antibody
Full Product Name
BLIMP1, CT (PRDM1, PR Domain Zinc Finger Protein 1, BLIMP-1, Beta-interferon Gene Positive Regulatory Domain I-binding Factor, PR Domain-containing Protein 1, Positive Regulatory Domain I-binding Factor 1, PRDI-BF1, PRDI-binding factor 1)
Product Gene Name
anti-PRDM1 antibody
Product Synonym Names
Anti -BLIMP1, CT (PRDM1, PR Domain Zinc Finger Protein 1, BLIMP-1, Beta-interferon Gene Positive Regulatory Domain I-binding Factor, PR Domain-containing Protein 1, Positive Regulatory Domain I-binding Factor 1, PRDI-BF1, PRDI-binding factor 1)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human PRDM1. Species sequence homology: mouse and rat
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
91,771 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (106534195..106557814). Location: 6q21
OMIM
603423
3D Structure
ModBase 3D Structure for O75626
Immunogen
Synthetic peptide corresponding to 13aa from near the C-terminal of human BLIMP1 (KLH).

Product Categories/Family for anti-PRDM1 antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-PRDM1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-PRDM1 antibody
Suitable for use in Immunofluorescence, ELISA, Western Blot and Immunohistochemistry.,
Dilution: Immunofluorescence: 20ug/ml
Western Blot: 0.5-1ug/ml
Immunohistochemistry (Formalin-fixed, paraffin-embedded): 3ug/ml

Immunohistochemistry (IHC) of anti-PRDM1 antibody

Human Colon, Lymphoid Follicle (formalin-fixed, paraffin-embedded) stained with PRDM1 antibody at 3ug/ml followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.
Rabbit Anti-PRDM1 Polyclonal Antibody – Cat# MBS6010086

Western Blot (WB) of anti-PRDM1 antibody

Western blot analysis of Blimp-1 in A549 cell lysate with Blimp-1 antibody at (A) 0.5 and (B) 1ug/ml.
Rabbit Anti-PRDM1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6010086

Other Notes

Small volumes of anti-PRDM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRDM1 purchase

MBS6010086 is an antibody targeting PRDM1. Also known as BLIMP1, CT (PRDM1, PR Domain Zinc Finger Protein 1, BLIMP-1, Beta-interferon Gene Positive Regulatory Domain I-binding Factor, PR Domain-containing Protein 1, Positive Regulatory Domain I-binding Factor 1, PRDI-BF1, PRDI-binding factor 1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRDM1. It may not necessarily be applicable to this product.

NCBI GI #
3493158
NCBI GeneID
639
NCBI Accession #
AAC33300.1
UniProt Primary Accession #
O75626
UniProt Secondary Accession #
Q86WM7; B2REA6; E1P5E0
UniProt Related Accession #
O75626
NCBI Official Full Name
beta-interferon gene positive-regulatory domain I binding factor
NCBI Official Synonym Full Names
PR domain containing 1, with ZNF domain
NCBI Official Symbol
PRDM1
NCBI Official Synonym Symbols
BLIMP1; PRDI-BF1
UniProt Protein Name
PR domain zinc finger protein 1
UniProt Synonym Protein Names
BLIMP-1; Beta-interferon gene positive regulatory domain I-binding factor; PR domain-containing protein 1; Positive regulatory domain I-binding factor 1
Protein Family
PR domain zinc finger protein
UniProt Gene Name
PRDM1
UniProt Synonym Gene Names
BLIMP1; PRDI-BF1
UniProt Entry Name
PRDM1_HUMAN
NCBI Protein Information
PR domain zinc finger protein 1; BLIMP-1; PRDI-binding factor-1; B-lymphocyte-induced maturation protein 1; beta-interferon gene positive-regulatory domain I binding factor

UniProt Comments for PRDM1

PRDM1: a transcriptional repressor that binds specifically to the PRDI element in the promoter of the beta-interferon gene and can inhibit virus-mediated IFN-¿ production. Recruits chromatin-modifying enzymes including histone deacetylases and methyltransferases. Drives the maturation of B-lymphocytes into Ig secreting cells. Interacts with PRMT5. Expression of Blimp-1 is sufficient to drive terminal differentiation of BCL1 lymphoma cells into antibody secreting plasma cells, increasing the expression of the cell surface marker Syndecan-1. In the B-cell lineage, Blimp-1 is specifically expressed in antibody-secreting cells including activated B and plasma cells. In addition, Blimp-1 has been found during macrophage differentiation and in a subset of T-cells suggesting that it may play a wider role in homeostasis and differentiation. Target genes of Blimp-1 transcriptional repression with potential roles in differentiation include c-Myc, CIITA, Pax5, Spi-B, and Id3.Three isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor; C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted; Transcription regulation; DNA-binding

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: cytoplasm; nucleus

Molecular Function: methyltransferase activity; protein binding; metal ion binding; histone deacetylase binding; transcription factor activity

Biological Process: methylation; negative regulation of lipopolysaccharide-mediated signaling pathway; eye photoreceptor cell development; cell fate commitment; transcription, DNA-dependent; positive regulation of B cell differentiation; negative regulation of B cell proliferation; negative regulation of transcription from RNA polymerase II promoter; post-embryonic development; germ cell development; maternal placenta development
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Research Articles on PRDM1

1. Two missense SNPs, chr6:106659789 (Ser354Asn) and chr6:106660076 (Leu450Phe) at PRDM1 on chromosome 6q21, were significantly associated with Crohn's disease and ulcerative colitis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRDM1 antibody

 Reference Product  PubMed Publications
 PAX5 antibody  >46 publications with PRDM1 and PAX5
 IRF4 antibody  >31 publications with PRDM1 and IRF4
 FOS antibody  >7 publications with PRDM1 and FOS
 PRMT5 antibody  >5 publications with PRDM1 and PRMT5
 SOX6 antibody  >4 publications with PRDM1 and SOX6
 HDAC2 antibody  >3 publications with PRDM1 and HDAC2
 TP53 antibody  >2 publications with PRDM1 and TP53
 EHMT2 antibody  >1 publications with PRDM1 and EHMT2

Pathways associated with anti-PRDM1 antibody

 Products by Pathway  Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 NOD Pathway antibodies  NOD Pathway Diagram

Diseases associated with anti-PRDM1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >113 publications with PRDM1 and Neoplasms
 Hematologic Diseases Antibodies  >22 publications with PRDM1 and Hematologic Diseases
 Neoplasms, Experimental Antibodies  >13 publications with PRDM1 and Neoplasms, Experimental
 Colitis Antibodies  >10 publications with PRDM1 and Colitis
 Inflammation Antibodies  >9 publications with PRDM1 and Inflammation
 Intestinal Diseases Antibodies  >8 publications with PRDM1 and Intestinal Diseases
 Cell Transformation, Neoplastic Antibodies  >8 publications with PRDM1 and Cell Transformation, Neoplastic
 Lupus Erythematosus, Systemic Antibodies  >8 publications with PRDM1 and Lupus Erythematosus, Systemic
 Necrosis Antibodies  >7 publications with PRDM1 and Necrosis
 Nervous System Diseases Antibodies  >7 publications with PRDM1 and Nervous System Diseases

Organs/Tissues associated with anti-PRDM1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >261 publications with PRDM1 and Blood
 Bone Antibodies  >55 publications with PRDM1 and Bone
 Lymph Node Antibodies  >44 publications with PRDM1 and Lymph Node
 Bone Marrow Antibodies  >32 publications with PRDM1 and Bone Marrow
 Spleen Antibodies  >30 publications with PRDM1 and Spleen
 Embryonic Tissue Antibodies  >28 publications with PRDM1 and Embryonic Tissue
 Skin Antibodies  >12 publications with PRDM1 and Skin
 Lung Antibodies  >9 publications with PRDM1 and Lung
 Liver Antibodies  >5 publications with PRDM1 and Liver
 Thymus Antibodies  >5 publications with PRDM1 and Thymus
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