Rabbit Anti-BLK Polyclonal Antibody – Cat# MBS6371277

Western Blot analysis of BLK expression in transfected 293T cell line by BLK polyclonal antibody. Lane 1: BLK transfected lysate (57.7kD). Lane 2: Non-transfected lysate.

BLK Antibody – Rabbit Polyclonal

Name: BLK Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6371277
Price: 1040 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6371277

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in… More details

$1040 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BLK, Polyclonal Antibody

Full Product Name

BLK (Tyrosine-protein Kinase Blk, B Lymphoid Tyrosine Kinase, p55-Blk) (AP)

Product Gene Name

anti-BLK antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Specificity

Recognizes human BLK.

Preparation and Storage

Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

57,706 Da

Chromosome Location

Chromosome: 8; NC_000008.10 (11351521..11422108). Location: 8p23-p22

OMIM

191305

3D Structure

ModBase 3D Structure for P51451

Immunogen

Full length human BLK, aa1-505 (NP_001706.2).

Immunogen Sequence

MGLVSSKKPDKEKPIKEKDKGQWSPLKVSAQDKDAPPLPPLVVFNHLTPPPPDEHLDEDKHFVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFVARVESLEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRPAPQNPWAQDEWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERLVRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSRPEERPTFEFLQSVLEDFYTATERQYELQP

Conjugate

Note

Preservative Free

Product Categories/Family for anti-BLK antibody

Antibodies; Protein Kinases

Applications Tested/Suitable for anti-BLK antibody

Western Blot (WB)

Application Notes for anti-BLK antibody

Applications are based on unconjugated antibody.

Other Notes

Small volumes of anti-BLK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BLK purchase

MBS6371277 is an antibody targeting BLK. Also known as BLK (Tyrosine-protein Kinase Blk, B Lymphoid Tyrosine Kinase, p55-Blk) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BLK. It may not necessarily be applicable to this product.

NCBI GI #

33469982

NCBI GeneID

640

NCBI Accession #

NP_001706.2

UniProt Primary Accession #

P51451

UniProt Secondary Accession #

Q16291; Q96IN1

UniProt Related Accession #

P51451

GenBank Nucleotide #

NM_001715.2

NCBI Official Full Name

tyrosine-protein kinase Blk

NCBI Official Synonym Full Names

B lymphoid tyrosine kinase

NCBI Official Symbol

BLK

NCBI Official Synonym Symbols

MODY11

UniProt Protein Name

Tyrosine-protein kinase Blk

UniProt Synonym Protein Names

B lymphocyte kinase; p55-Blk

Protein Family

Tyrosine-protein kinase

UniProt Gene Name

BLK

UniProt Entry Name

BLK_HUMAN

NCBI Protein Information

tyrosine-protein kinase Blk; p55-Blk; b lymphocyte kinase; BLK nonreceptor tyrosine kinase

NCBI Summary for BLK

This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]

UniProt Comments for BLK

BLK: a nonreceptor tyrosine kinase of the Src family. Expressed predominantly in B lymphocytes

Protein type: Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Kinase, protein; EC 2.7.10.2; TK group; Src family

Chromosomal Location of Human Ortholog: 8p23-p22

Cellular Component: extrinsic to internal side of plasma membrane

Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: B cell receptor signaling pathway; innate immune response; positive regulation of insulin secretion; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of cell proliferation; T cell differentiation

Disease: Maturity-onset Diabetes Of The Young, Type 11

Research Articles on BLK

1. Blk allele expression differences at the protein level are restricted to early B cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BLK antibody

Reference Product	PubMed Publications
BCR antibody	>18 publications with BLK and BCR
CD79A antibody	>5 publications with BLK and CD79A
CD79B antibody	>4 publications with BLK and CD79B
FCGR2B antibody	>2 publications with BLK and FCGR2B
FCGR2A antibody	>2 publications with BLK and FCGR2A
PLCG2 antibody	>1 publications with BLK and PLCG2
CBL antibody	>1 publications with BLK and CBL
BCL2 antibody	>1 publications with BLK and BCL2

Pathways associated with anti-BLK antibody

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Alpha-synuclein Signaling Pathway antibodies	Alpha-synuclein Signaling Pathway Diagram
Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway antibodies	Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway Diagram
Apoptosis Modulation And Signaling Pathway antibodies	Apoptosis Modulation And Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
CXCR4-mediated Signaling Events Pathway antibodies	CXCR4-mediated Signaling Events Pathway Diagram
Class I PI3K Signaling Events Pathway antibodies	Class I PI3K Signaling Events Pathway Diagram
EPHA Forward Signaling Pathway antibodies	EPHA Forward Signaling Pathway Diagram
Ephrin B Reverse Signaling Pathway antibodies	Ephrin B Reverse Signaling Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram

Diseases associated with anti-BLK antibody

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>64 publications with BLK and Immune System Diseases
Neoplasms Antibodies	>56 publications with BLK and Neoplasms
Lupus Erythematosus, Systemic Antibodies	>38 publications with BLK and Lupus Erythematosus, Systemic
Nervous System Diseases Antibodies	>19 publications with BLK and Nervous System Diseases
Arthritis, Rheumatoid Antibodies	>17 publications with BLK and Arthritis, Rheumatoid
Cardiovascular Diseases Antibodies	>15 publications with BLK and Cardiovascular Diseases
Brain Diseases Antibodies	>14 publications with BLK and Brain Diseases
Necrosis Antibodies	>13 publications with BLK and Necrosis
Inflammation Antibodies	>12 publications with BLK and Inflammation
Drug Toxicity Antibodies	>10 publications with BLK and Drug Toxicity

Organs/Tissues associated with anti-BLK antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>127 publications with BLK and Blood
Spleen Antibodies	>15 publications with BLK and Spleen
Lung Antibodies	>12 publications with BLK and Lung
Bone Marrow Antibodies	>10 publications with BLK and Bone Marrow
Lymph Node Antibodies	>6 publications with BLK and Lymph Node
Lymph Antibodies	>6 publications with BLK and Lymph
Thymus Antibodies	>5 publications with BLK and Thymus
Intestine Antibodies	>3 publications with BLK and Intestine
Connective Tissue Antibodies	>3 publications with BLK and Connective Tissue
Mammary Gland Antibodies	>2 publications with BLK and Mammary Gland