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BMP15 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6465619

MBS6465619 is an antibody targeting BMP15. Also known as BMP15, ID (Bone Morphogenetic Protein 15, BMP-15, Growth/Differentiation Factor 9B, GDF-9B, GDF9B) (FITC). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BMP15, Polyclonal Antibody
Full Product Name
BMP15, ID (Bone Morphogenetic Protein 15, BMP-15, Growth/Differentiation Factor 9B, GDF-9B, GDF9B) (FITC)
Product Gene Name
anti-BMP15 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human BMP15.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer.
Molecular Weight
45,055 Da
OMIM
300247
3D Structure
ModBase 3D Structure for O95972
Immunogen
Synthetic peptide selected from the center region of human BMP15 (KLH).
Conjugate
FITC
Note
Preservative Free

Product Categories/Family for anti-BMP15 antibody

Antibodies; Growth Factors; Cytokines
Applications Tested/Suitable for anti-BMP15 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-BMP15 antibody
IHC: 1:10-1:50
ELISA: 1:1,000
WB: 1:50-1:100
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-BMP15 antibody

Western blot analysis of BMP15 Antibody (Center) in CEM cell line lysates (35ug/lane). BMP15 (arrow) was detected using the purified Pab.
Rabbit Anti-BMP15 Polyclonal Antibody – Cat# MBS6465619

Immunohistochemistry (IHC) of anti-BMP15 antibody

Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with BMP15 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-BMP15 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6465619

Product References and Citations for anti-BMP15 antibody

1. Liao, W.X., et al., J. Biol. Chem. 278(6):3713-3719 (2003). 2. Moore, R.K., et al., J. Biol. Chem. 278(1):304-310 (2003). 3. Galloway, S.M., et al., Nat. Genet. 25(3):279-283 (2000). 4. Aaltonen, J., et al., J. Clin. Endocrinol. Metab. 84(8):2744-2750 (1999). 5. Dube, J.L., et al., Mol. Endocrinol. 12(12):1809-1817 (1998).

Other Notes

Small volumes of anti-BMP15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BMP15. It may not necessarily be applicable to this product.

NCBI GI #
257743454
NCBI GeneID
9210
NCBI Accession #
NP_005439
UniProt Primary Accession #
O95972
UniProt Secondary Accession #
Q17RM6; Q5JST1; Q9UMS1
UniProt Related Accession #
O95972
GenBank Nucleotide #
NM_005448.2
NCBI Official Full Name
bone morphogenetic protein 15
NCBI Official Synonym Full Names
bone morphogenetic protein 15
NCBI Official Symbol
BMP15
NCBI Official Synonym Symbols
ODG2; POF4; GDF9B
UniProt Protein Name
Bone morphogenetic protein 15
UniProt Synonym Protein Names
Growth/differentiation factor 9B
Protein Family
Bone morphogenetic protein
UniProt Gene Name
BMP15
UniProt Synonym Gene Names
GDF9B; BMP-15; GDF-9B
UniProt Entry Name
BMP15_HUMAN
NCBI Protein Information
bone morphogenetic protein 15; BMP-15; GDF-9B; growth/differentiation factor 9B

NCBI Summary for BMP15

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9. Defects in this gene are the cause of ovarian dysgenesis 2.[provided by RefSeq, Sep 2009]
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UniProt Comments for BMP15

BMP15: May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. Defects in BMP15 are the cause of ovarian dysgenesis type 2 (ODG2); also known as X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian dysgenesis leads to ovarian failure and accounts for about half of the cases of primary amenorrhea. Defects in BMP15 are the cause of premature ovarian failure type 4 (POF4). An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: extracellular space; cytoplasm

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; regulation of apoptosis; granulosa cell development; ovarian follicle development; positive regulation of transcription, DNA-dependent; regulation of MAPKKK cascade; female gamete generation; cell development

Disease: Ovarian Dysgenesis 2
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Research Articles on BMP15

1. Oocyte-derived BMP15 decreases gap junction intercellular communication activity between human granulosa cells by down-regulating Cx43 expression, most likely via a Smad-dependent signaling pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BMP15 antibody

 Reference Product  PubMed Publications
 GDF9 antibody  >292 publications with BMP15 and GDF9
 BMPR2 antibody  >34 publications with BMP15 and BMPR2
 BMPR1B antibody  >18 publications with BMP15 and BMPR1B
 FSHR antibody  >13 publications with BMP15 and FSHR
 NOBOX antibody  >5 publications with BMP15 and NOBOX
 FIGLA antibody  >5 publications with BMP15 and FIGLA
 FGF7 antibody  >2 publications with BMP15 and FGF7
 DIAPH2 antibody  >1 publications with BMP15 and DIAPH2
 POF1B antibody  >1 publications with BMP15 and POF1B

Pathways associated with anti-BMP15 antibody

 Products by Pathway  Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram
 Ovarian Steroidogenesis Pathway antibodies  Ovarian Steroidogenesis Pathway Diagram

Diseases associated with anti-BMP15 antibody

 Disease Name  Pubmed Publications
 Infertility, Female Antibodies  >55 publications with BMP15 and Infertility, Female
 Neoplasms Antibodies  >13 publications with BMP15 and Neoplasms
 Polycystic Ovary Syndrome Antibodies  >12 publications with BMP15 and Polycystic Ovary Syndrome
 Urogenital Abnormalities Antibodies  >8 publications with BMP15 and Urogenital Abnormalities
 Necrosis Antibodies  >4 publications with BMP15 and Necrosis
 Abnormalities, Drug-Induced Antibodies  >2 publications with BMP15 and Abnormalities, Drug-Induced
 Weight Loss Antibodies  >2 publications with BMP15 and Weight Loss
 Immune System Diseases Antibodies  >2 publications with BMP15 and Immune System Diseases
 Hyperplasia Antibodies  >1 publications with BMP15 and Hyperplasia
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