Bone Morphogenetic Protein 7 (BMP7) Antibody – Rabbit Polyclonal

BMP7: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Expressed in the kidney and bladder. Lower levels seen in the brain. Belongs to the TGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; protein binding; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; cardiac muscle development; dendrite development; epithelial to mesenchymal transition; hindbrain development; inhibition of NF-kappaB transcription factor; mesenchymal cell differentiation; mesonephros development; metanephros development; negative regulation of cell cycle; negative regulation of MAP kinase activity; negative regulation of mitosis; negative regulation of neuron differentiation; negative regulation of NF-kappaB import into nucleus; negative regulation of phosphorylation; negative regulation of transcription, DNA-dependent; neural fold elevation formation; neurite morphogenesis; pharyngeal system development; positive regulation of bone mineralization; positive regulation of heterotypic cell-cell adhesion; positive regulation of osteoblast differentiation; positive regulation of transcription, DNA-dependent; regulation of apoptosis; skeletal development; steroid hormone mediated signaling; ureteric bud development