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BPGM Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6278755

2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its… More details

$1060 / 0.1 mL +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
BPGM, Polyclonal Antibody
Full Product Name
BPGM, CT (BPGM, Bisphosphoglycerate mutase, 2,3-bisphosphoglycerate mutase, erythrocyte, 2,3-bisphosphoglycerate synthase, 2,3-diphosphoglycerate mutase, BPG-dependent PGAM) (MaxLight 650)
Product Gene Name
anti-BPGM antibody
Product Synonym Names
BPGM; Bisphosphoglycerate mutase; 2,3-bisphosphoglycerate mutase; erythrocyte; 2,3-bisphosphoglycerate synthase; 2,3-diphosphoglycerate mutase; BPG-dependent PGAM
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human BPGM.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
31 kDa (267aa), confirmed by MALDI-TOF
OMIM
phenotype 613896
3D Structure
ModBase 3D Structure for P07738
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 230-259 in the C-terminal region of human BPGM. Species sequence homology: monkey
Conjugate
MaxLight650
Note
Preservative Free

Product Categories/Family for anti-BPGM antibody

Antibodies; Enzymes; Synthase
Applications Tested/Suitable for anti-BPGM antibody
Western Blot (WB), FLISA
Application Notes for anti-BPGM antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-BPGM antibody

Western Blot using MBS645558 (1:2000) Lane 1: MDA-MB-453 whole cell lysate 20ug/lane Lane 2: Hela whole cell lysate 20ug/lane Secondary IgG (HRP) Goat Anti-Rabbit Predicted band size: 30kD Blocking/Dilution buffer: 5% NFDM/TBST.
Rabbit Anti-BPGM Polyclonal Antibody – Cat# MBS6278755

Product References and Citations for anti-BPGM antibody

1. Lamesch, P., et al. Genomics 89(3):307-315(2007). 2. Wang, Y., et al. J. Biol. Chem. 281(51):39642-39648(2006). 3. Wang, Y., et al. J. Biol. Chem. 279(37):39132-39138(2004). 4. Fujita, T., et al. J. Biochem. 124(6):1237-1244(1998).

Other Notes

Small volumes of anti-BPGM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BPGM purchase

MBS6278755 is an antibody targeting BPGM. Also known as BPGM, CT (BPGM, Bisphosphoglycerate mutase, 2,3-bisphosphoglycerate mutase, erythrocyte, 2,3-bisphosphoglycerate synthase, 2,3-diphosphoglycerate mutase, BPG-dependent PGAM) (MaxLight 650). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BPGM. It may not necessarily be applicable to this product.

NCBI GI #
40353764
NCBI GeneID
669
NCBI Accession #
NP_954655.1
NCBI Related Accession #
NP_001715.1
UniProt Primary Accession #
P07738
UniProt Secondary Accession #
A4D1N9
UniProt Related Accession #
P07738
GenBank Nucleotide #
NM_199186.2
NCBI Official Full Name
bisphosphoglycerate mutase
NCBI Official Synonym Full Names
2,3-bisphosphoglycerate mutase
NCBI Official Symbol
BPGM
NCBI Official Synonym Symbols
DPGM
UniProt Protein Name
Bisphosphoglycerate mutase
UniProt Synonym Protein Names
2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase (EC:3.1.3.13, EC:5.4.2.11); 2,3-diphosphoglycerate mutase; DPGM; BPG-dependent PGAM
Protein Family
Bisphosphoglycerate mutase
UniProt Gene Name
BPGM
UniProt Synonym Gene Names
BPGM; DPGM
UniProt Entry Name
PMGE_HUMAN
NCBI Protein Information
bisphosphoglycerate mutase

UniProt Comments for BPGM

BPGM: Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities. Defects in BPGM are the cause of bisphosphoglycerate mutase deficiency (BPGMD). A disease characterized by hemolytic anemia, splenomegaly, cholelithiasis and cholecystitis. Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.

Protein type: EC 5.4.2.4; EC 3.1.3.13; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Phosphatase (non-protein); EC 5.4.2.11; Isomerase

Chromosomal Location of Human Ortholog: 7q33

Molecular Function: phosphoglycerate mutase activity; bisphosphoglycerate mutase activity; bisphosphoglycerate phosphatase activity

Biological Process: erythrocyte development; glycolysis; dephosphorylation; carbohydrate metabolic process; respiratory gaseous exchange

Disease: Bisphosphoglycerate Mutase Deficiency
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BPGM antibody

 Reference Product  PubMed Publications
 GPI antibody  >2 publications with BPGM and GPI
 PGAM2 antibody  >1 publications with BPGM and PGAM2
 ALDOA antibody  >1 publications with BPGM and ALDOA
 GAPDH antibody  >1 publications with BPGM and GAPDH

Pathways associated with anti-BPGM antibody

 Products by Pathway  Pathway Diagram
 Biosynthesis Of Antibiotics Pathway antibodies  Biosynthesis Of Antibiotics Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycine, Serine And Threonine Metabolism Pathway antibodies  Glycine, Serine And Threonine Metabolism Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Rapoport-Luebering Glycolytic Shunt Pathway antibodies  Rapoport-Luebering Glycolytic Shunt Pathway Diagram
 Rapoport-Luebering Glycolytic Shunt Pathway antibodies  Rapoport-Luebering Glycolytic Shunt Pathway Diagram
 Gluconeogenesis Pathway antibodies  Gluconeogenesis Pathway Diagram
 Gluconeogenesis III Pathway antibodies  Gluconeogenesis III Pathway Diagram

Diseases associated with anti-BPGM antibody

 Disease Name  Pubmed Publications
 BISPHOSPHOGLYCERATE MUTASE DEFICIENCY Antibodies  >5 publications with BPGM and BISPHOSPHOGLYCERATE MUTASE DEFICIENCY
 Lung Neoplasms Antibodies  >1 publications with BPGM and Lung Neoplasms
 Lung Diseases Antibodies  >1 publications with BPGM and Lung Diseases
 Kidney Diseases Antibodies  >1 publications with BPGM and Kidney Diseases

Organs/Tissues associated with anti-BPGM antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >19 publications with BPGM and Blood
 Embryonic Tissue Antibodies  >2 publications with BPGM and Embryonic Tissue
 Placenta Antibodies  >2 publications with BPGM and Placenta
 Liver Antibodies  >1 publications with BPGM and Liver
 Lung Antibodies  >1 publications with BPGM and Lung
 Kidney Antibodies  >1 publications with BPGM and Kidney
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