Rabbit Anti-BRAK Polyclonal Antibody – Cat# MBS695529

BRAK Antibody – Rabbit Polyclonal

Name: BRAK Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS695529
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS695529

Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hBRAK. Anti-Human BRAK specific antibody was purified by affinity chromatography and then biotinylated. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

BRAK, Polyclonal Antibody

Full Product Name

Biotinylated Anti-hBRAK

Product Gene Name

anti-BRAK antibody

Product Synonym Names

Biotinylated Anti-Human BRAK

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human

Form/Format

Biotin

Preparation and Storage

At -20 degree C

Molecular Weight

13,078 Da

OMIM

604186

3D Structure

ModBase 3D Structure for O95715

Immunogen

Recombinant Human BRAK

Applications Tested/Suitable for anti-BRAK antibody

ELISA (EIA), Western Blot (WB)

Application Notes for anti-BRAK antibody

Direct Detection: To detect hBRAK by direct ELISA (using 100 mul/well antibody solution) a concentration of 0.25 - 1.0 mug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hBRAK.

Sandwich ELISA: To detect hBRAK by sandwich ELISA (using 100 mul/well antibody solution) a concentration of 0.25 - 1.0 mug/ml of this antibody is required. This biotinylated polyclonal antibody, in conjunction with Polyclonal Anti-Human BRAK as a capture antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hBRAK.

Western Blot: To detect hBRAK by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 ug/ml. Used in conjunction with compatible secondary reagents the detection limit for recombinant hBRAK is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

Other Notes

Small volumes of anti-BRAK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BRAK purchase

MBS695529 is an antibody targeting BRAK. Also known as Biotinylated Anti-hBRAK. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BRAK. It may not necessarily be applicable to this product.

NCBI GI #

292495003

NCBI GeneID

9547

NCBI Accession #

O95715.2

UniProt Primary Accession #

O95715

UniProt Secondary Accession #

Q6UW97; Q86U69; Q9BTR1; Q9NS21; B3KQU8

UniProt Related Accession #

O95715

NCBI Official Full Name

C-X-C motif chemokine 14

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 14

NCBI Official Symbol

CXCL14

NCBI Official Synonym Symbols

KEC; KS1; BMAC; BRAK; NJAC; MIP2G; MIP-2g; SCYB14

UniProt Protein Name

C-X-C motif chemokine 14

UniProt Synonym Protein Names

Chemokine BRAK; MIP-2G; Small-inducible cytokine B14

Protein Family

C-X-C motif chemokine

UniProt Gene Name

CXCL14

UniProt Synonym Gene Names

MIP2G; NJAC; SCYB14

UniProt Entry Name

CXL14_HUMAN

NCBI Protein Information

C-X-C motif chemokine 14; bolekine; MIP-2 gamma; chemokine BRAK; breast and kidney; tumor-suppressing chemokine; small-inducible cytokine B14; CXC chemokine in breast and kidney; small inducible cytokine subfamily B (Cys-X-Cys), member 14 (BRAK)

NCBI Summary for BRAK

This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]

UniProt Comments for BRAK

CXCL14: Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis; Chemokine

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: Golgi apparatus; extracellular space

Molecular Function: chemokine activity

Biological Process: cell-cell signaling; immune response; signal transduction; negative regulation of myoblast differentiation; chemotaxis; inner ear development

Research Articles on BRAK

1. CXCL14 displays antimicrobial activity against E. coli and S. aureus.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BRAK antibody

Reference Product	PubMed Publications
CXCR4 antibody	>11 publications with BRAK and CXCR4
CCR5 antibody	>2 publications with BRAK and CCR5
CXCR2 antibody	>2 publications with BRAK and CXCR2
CXCR3 antibody	>2 publications with BRAK and CXCR3
CCR7 antibody	>1 publications with BRAK and CCR7
CX3CR1 antibody	>1 publications with BRAK and CX3CR1
CXCR1 antibody	>1 publications with BRAK and CXCR1
CCR6 antibody	>1 publications with BRAK and CCR6
CCR1 antibody	>1 publications with BRAK and CCR1

Pathways associated with anti-BRAK antibody

Products by Pathway	Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Senescence And Autophagy Pathway antibodies	Senescence And Autophagy Pathway Diagram

Diseases associated with anti-BRAK antibody

Disease Name	Pubmed Publications
Carcinoma Antibodies	>36 publications with BRAK and Carcinoma
Inflammation Antibodies	>28 publications with BRAK and Inflammation
Adenocarcinoma Antibodies	>11 publications with BRAK and Adenocarcinoma
Breast Neoplasms Antibodies	>11 publications with BRAK and Breast Neoplasms
Neoplasm Metastasis Antibodies	>8 publications with BRAK and Neoplasm Metastasis
Lung Neoplasms Antibodies	>8 publications with BRAK and Lung Neoplasms
Necrosis Antibodies	>7 publications with BRAK and Necrosis
Disease Models, Animal Antibodies	>6 publications with BRAK and Disease Models, Animal
Liver Diseases Antibodies	>6 publications with BRAK and Liver Diseases
Fibrosis Antibodies	>5 publications with BRAK and Fibrosis

Organs/Tissues associated with anti-BRAK antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>29 publications with BRAK and Blood
Lung Antibodies	>17 publications with BRAK and Lung
Brain Antibodies	>16 publications with BRAK and Brain
Skin Antibodies	>13 publications with BRAK and Skin
Liver Antibodies	>13 publications with BRAK and Liver
Prostate Antibodies	>10 publications with BRAK and Prostate
Kidney Antibodies	>10 publications with BRAK and Kidney
Lymph Node Antibodies	>8 publications with BRAK and Lymph Node
Muscle Antibodies	>8 publications with BRAK and Muscle
Bone Antibodies	>7 publications with BRAK and Bone