BRD7 Antibody – Rabbit Polyclonal

BRD7: a bromodomain protein that binds dishevelled-1 (DVL1) and enhances Wnt signaling by inhibiting GSK3B. Interacts with DVL1, PTPN13, IRF2 and HNRPUL1. Associates with histones and E1B-AP5. Binds acetylated histone peptides, most notably H3 peptide acetylated at Lys14. Associates with histones and E1B-AP5. Its bromodomain is found in many chromatin-associated proteins and most known histone acetyltransferases. Inhibits G1-S progression by transcriptional regulation of molecules in the ras and Rb pathways. Plays an important role in transcriptional activation and chromatin remodeling. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription regulation; Tumor suppressor; Cell cycle regulation; Histone-binding

Chromosomal Location of Human Ortholog: 16q12

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding; histone binding; p53 binding; transcription coactivator activity; transcription factor binding; transcription corepressor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; negative regulation of cell proliferation; Wnt receptor signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of histone acetylation; negative regulation of transcription, DNA-dependent; cell cycle