Rabbit Anti-BRSK1 Polyclonal Antibody – Cat# MBS6465749

BRSK1 Antibody – Rabbit Polyclonal

Name: BRSK1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6465749
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6465749

MBS6465749 is an antibody targeting BRSK1. Also known as BRSK1, NT (BR Serine/Threonine-protein Kinase 1, SAD1 Kinase, Serine/Threonine-protein Kinase SAD-B, KIAA1811, SAD1) (MaxLight 550). Reactive in Human. Host: Rabbit. More details

$1060 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BRSK1, Polyclonal Antibody

Full Product Name

BRSK1, NT (BR Serine/Threonine-protein Kinase 1, SAD1 Kinase, Serine/Threonine-protein Kinase SAD-B, KIAA1811, SAD1) (MaxLight 550)

Product Gene Name

anti-BRSK1 antibody

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

Purity/Purification

Purified by Protein G Affinity Chromatography.

Specificity

Recognizes human BRSK1.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

38,782 Da

OMIM

609235

3D Structure

ModBase 3D Structure for Q8TDC3

Immunogen

Synthetic peptide selected from the N-terminal region of human BRSK1 (KLH).

Conjugate

MaxLight550

Note

Preservative Free

Product Categories/Family for anti-BRSK1 antibody

Antibodies; Protein Kinases

Applications Tested/Suitable for anti-BRSK1 antibody

Western Blot (WB), FLISA

Application Notes for anti-BRSK1 antibody

WB: 1:100-1:500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-BRSK1 antibody

1. Lu, R., et al., J. Biol. Chem. 279(30):31164-31170 (2004). 2. Lizcano, J.M., et al., EMBO J. 23(4):833-843 (2004).

Other Notes

Small volumes of anti-BRSK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BRSK1. It may not necessarily be applicable to this product.

NCBI GI #

24308326

NCBI GeneID

84446

NCBI Accession #

NP_115806

UniProt Primary Accession #

Q8TDC3

UniProt Secondary Accession #

Q5J5B5; Q8NDD0; Q8NDR4; Q8TDC2; Q96AV4; Q96JL4; F1DG44

UniProt Related Accession #

Q8TDC3

GenBank Nucleotide #

NM_032430.1

NCBI Official Full Name

serine/threonine-protein kinase BRSK1

NCBI Official Synonym Full Names

BR serine/threonine kinase 1

NCBI Official Symbol

BRSK1

NCBI Official Synonym Symbols

hSAD1

UniProt Protein Name

Serine/threonine-protein kinase BRSK1

UniProt Synonym Protein Names

Brain-selective kinase 1 (EC:2.7.11.26); Brain-specific serine/threonine-protein kinase 1; BR serine/threonine-protein kinase 1; Serine/threonine-protein kinase SAD-B; Synapses of Amphids Defective homolog 1; SAD1 homolog; hSAD1

Protein Family

Serine/threonine-protein kinase

UniProt Gene Name

BRSK1

UniProt Synonym Gene Names

KIAA1811; SAD1; SADB; BR serine/threonine-protein kinase 1; SAD1 homolog; hSAD1

UniProt Entry Name

BRSK1_HUMAN

NCBI Protein Information

serine/threonine-protein kinase BRSK1

UniProt Comments for BRSK1

BRSK1: a serine/threonine protein kinase of the CAMK group. Closely related to AMPK. Activated by the kinase LKB1. Acts as checkpoint kinase upon DNA damage induced by UV or methyl methane sulfonate. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo. Translocates from the cytoplasm to the nucleus in response to UV- or MMS-induced DNA damage. BRSK1 and BRSK2 are required for neuronal polarization. Widely expressed with highest levels in the brain and testis. Two alternatively spliced isoforms have been described.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.26; EC 2.7.11.1; Protein kinase, CAMK; Kinase, protein; CAMK group; CAMKL family; BRSK subfamily

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: nucleoplasm; centrosome; synaptic vesicle; cytoplasm; cell junction; nucleus

Molecular Function: protein serine/threonine kinase activity; gamma-tubulin binding; tau-protein kinase activity; magnesium ion binding; protein kinase binding; ATP binding

Biological Process: neuron differentiation; axonogenesis; establishment of cell polarity; neurotransmitter secretion; response to ionizing radiation; G2/M transition DNA damage checkpoint; centrosome duplication; response to DNA damage stimulus; protein amino acid phosphorylation; response to UV

Research Articles on BRSK1

1. BRSK1 is a novel tumor suppressor in breast cancer which inversely correlated with Jab1 expression.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-BRSK1 antibody

Reference Product	PubMed Publications
WEE1 antibody	>1 publications with BRSK1 and WEE1
CDC25C antibody	>1 publications with BRSK1 and CDC25C

Pathways associated with anti-BRSK1 antibody

Products by Pathway	Pathway Diagram
LKB1 Signaling Events Pathway antibodies	LKB1 Signaling Events Pathway Diagram

Organs/Tissues associated with anti-BRSK1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>10 publications with BRSK1 and Brain
Nerve Antibodies	>3 publications with BRSK1 and Nerve
Testis Antibodies	>1 publications with BRSK1 and Testis