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BVES Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6279348

This gene encodes a member of the POP family of proteins containing three putative transmembrane domains. This gene is expressed in cardiac and skeletal muscle and may play an important role in development of these tissues. The mouse ortholog may be involved… More details

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Product Overview

Online Datasheet in PDF
Product Name
BVES, Polyclonal Antibody
Full Product Name
BVES, CT (BVES, POP1, POPDC1, Blood vessel epicardial substance, Popeye domain-containing protein 1) (MaxLight 550)
Product Gene Name
anti-BVES antibody
Product Synonym Names
BVES; POP1; POPDC1; Blood vessel epicardial substance; Popeye domain-containing protein 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
OMIM
604577
3D Structure
ModBase 3D Structure for Q8NE79
Immunogen
BVES antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 312-342 amino acids from the C-terminal region of human BVES.
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-BVES antibody

Antibodies; Cardiac Markers
Applications Tested/Suitable for anti-BVES antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-BVES antibody
IHC: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-BVES antibody

Kim, M., et al. Carcinogenesis 31(9):1685-1693(2010). Zhao, J., et al. BMC Med. Genet. 11, 96 (2010): Sulem, P., et al. Nat. Genet. 41(6):734-738(2009). Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008). Feng, Q., et al. Cancer Epidemiol. Biomarkers Prev. 17(3):645-654(2008).

Other Notes

Small volumes of anti-BVES antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BVES purchase

MBS6279348 is an antibody targeting BVES. Also known as BVES, CT (BVES, POP1, POPDC1, Blood vessel epicardial substance, Popeye domain-containing protein 1) (MaxLight 550). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for BVES. It may not necessarily be applicable to this product.

NCBI GI #
22202608
NCBI GeneID
11149
NCBI Accession #
NP_009004.2
NCBI Related Accession #
NP_671488.1
UniProt Primary Accession #
Q8NE79
UniProt Related Accession #
Q8NE79
GenBank Nucleotide #
NP_009004.2
NCBI Official Full Name
blood vessel epicardial substance
NCBI Official Synonym Full Names
blood vessel epicardial substance
NCBI Official Symbol
BVES
NCBI Official Synonym Symbols
POP1; HBVES; CARICK; LGMD2X; POPDC1; LGMDR25
UniProt Protein Name
Blood vessel epicardial substance
UniProt Synonym Protein Names
Popeye domain-containing protein 1; Popeye protein 1
Protein Family
Blood vessel epicardial substance
UniProt Gene Name
BVES
UniProt Synonym Gene Names
POP1; POPDC1; hBVES; Popeye protein 1
UniProt Entry Name
POPD1_HUMAN
NCBI Protein Information
blood vessel epicardial substance

NCBI Summary for BVES

This gene encodes a member of the POP family of proteins containing three putative transmembrane domains. This gene is expressed in cardiac and skeletal muscle and may play an important role in development of these tissues. The mouse ortholog may be involved in the regeneration of adult skeletal muscle and may act as a cell adhesion molecule in coronary vasculogenesis. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]
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UniProt Comments for BVES

BVES: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3- mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading. Belongs to the popeye family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: tight junction; plasma membrane; integral to membrane; lateral plasma membrane

Molecular Function: cAMP binding; structural molecule activity

Biological Process: vesicle-mediated transport; regulation of cell shape; regulation of membrane potential; muscle development; positive regulation of locomotion; regulation of heart rate; hemopoietic progenitor cell differentiation; positive regulation of receptor recycling
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Research Articles on BVES

1. c.385C>T (p.R129W) is a functional SNP of the BVES gene that reduces the transcriptional activity of BVES in vitro and in vivo in TOF tissues. This subsequently affects the transcriptional activities of GATA4 and NKX2.5 related to TOF. These findings suggest that c.385C>T may be associated with the risk of TOF in the Han Chinese population.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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