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C6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6469975

MBS6469975 is an antibody targeting C6. Also known as C6, NT (Complement Component C6) (MaxLight 490). Reactive in Human. Host: Rabbit. More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
C6, Polyclonal Antibody
Full Product Name
C6, NT (Complement Component C6) (MaxLight 490)
Product Gene Name
anti-C6 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human C6.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
105 KD
Chromosome Location
Chromosome: 5; NC_000005.9 (41142336..41261540, complement). Location: 5p13
OMIM
217050
3D Structure
ModBase 3D Structure for P13671
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 30-58 in the N-terminal region of human C6.
Conjugate
MaxLight490
Note
Preservative Free

Product Categories/Family for anti-C6 antibody

Antibodies; Complement
Applications Tested/Suitable for anti-C6 antibody
Immunohistochemistry (IHC) Paraffin, FLISA, Western Blot (WB), Immunofluorescence (IF), Flow Cytometry (FC/FACS)
Application Notes for anti-C6 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-C6 antibody

Western Blot analysis of MDA-MB231 cell line lysates (35ug/lane) using C7850-35G. C6 (arrow) was detected using C7850-35G.
Rabbit Anti-C6 Polyclonal Antibody – Cat# MBS6469975

Immunohistochemistry (IHC) of anti-C6 antibody

Immunohistochemistry analysis in formalin-fixed and paraffin-embedded human breast carcinoma reacted with C7850-35G, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of C7850-35G for immunohistochemistry.
Rabbit Anti-C6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6469975

Flow Cytometry (FC/FACS) of anti-C6 antibody

Flow Cytometric analysis of MDA-231 cells using C7850-35G (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-C6 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6469975

Immunofluorescence (IF) of anti-C6 antibody

Confocal immunofluorescent analysis with MDA-MB231 cells using C7850-35G followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-C6 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6469975

Product References and Citations for anti-C6 antibody

1. Wu, C., et.al., Proteomics 7(11), 1775-1785 (2007).

Other Notes

Small volumes of anti-C6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for C6. It may not necessarily be applicable to this product.

NCBI GI #
169636415
NCBI GeneID
729
NCBI Accession #
NP_000056.2
UniProt Primary Accession #
P13671
UniProt Related Accession #
P13671
GenBank Nucleotide #
NM_000065.3
NCBI Official Full Name
complement component C6
NCBI Official Synonym Full Names
complement component 6
NCBI Official Symbol
C6
UniProt Protein Name
Complement component C6
Protein Family
Complement component
UniProt Gene Name
C6
UniProt Entry Name
CO6_HUMAN
NCBI Protein Information
complement component C6

NCBI Summary for C6

This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]
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UniProt Comments for C6

C6: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C6 are the cause of complement component 6 deficiency (C6D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 5p13

Cellular Component: membrane attack complex; extracellular region

Molecular Function: protein binding

Biological Process: positive regulation of angiogenesis; positive regulation of activation of membrane attack complex; in utero embryonic development; cytolysis; regulation of complement activation; innate immune response; complement activation, classical pathway; complement activation

Disease: Complement Component 6 Deficiency
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Research Articles on C6

1. Crystal structure of C5b-6 suggests structural basis for priming assembly of the membrane attack complex.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-C6 antibody

 Products by Pathway  Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Systemic Lupus Erythematosus Pathway antibodies  Systemic Lupus Erythematosus Pathway Diagram

Diseases associated with anti-C6 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3915 publications with C6 and Neoplasms
 Nervous System Diseases Antibodies  >2937 publications with C6 and Nervous System Diseases
 Brain Diseases Antibodies  >1430 publications with C6 and Brain Diseases
 Necrosis Antibodies  >372 publications with C6 and Necrosis
 Complement Component 6 Deficiency Antibodies  >301 publications with C6 and Complement Component 6 Deficiency
 Immune System Diseases Antibodies  >290 publications with C6 and Immune System Diseases
 Inflammation Antibodies  >256 publications with C6 and Inflammation
 Edema Antibodies  >154 publications with C6 and Edema
 Congenital Abnormalities Antibodies  >132 publications with C6 and Congenital Abnormalities
 Kidney Diseases Antibodies  >131 publications with C6 and Kidney Diseases

Organs/Tissues associated with anti-C6 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >472 publications with C6 and Liver
 Kidney Antibodies  >370 publications with C6 and Kidney
 Heart Antibodies  >299 publications with C6 and Heart
 Lung Antibodies  >241 publications with C6 and Lung
 Connective Tissue Antibodies  >85 publications with C6 and Connective Tissue
 Bladder Antibodies  >72 publications with C6 and Bladder
 Pancreas Antibodies  >36 publications with C6 and Pancreas
 Testis Antibodies  >35 publications with C6 and Testis
 Uterus Antibodies  >15 publications with C6 and Uterus
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