• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CACNA2D4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9210313

CACNA2D4 is a member of the alpha-2/delta subunitfamily, a protein in the voltage-dependent calcium channel complex.Calcium channels mediate the influx of calcium ions into the cellupon membrane polarization and consist of a complex of alpha-1,alpha-2/delta,… More details

$240 / 0.08 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CACNA2D4, Polyclonal Antibody
Full Product Name
CACNA2D4 Antibody (N-term)
Product Gene Name
Product Synonym Names
Voltage-dependent calcium channel subunit alpha-2/delta-4; Voltage-gated calcium channel subunit alpha-2/delta-4; Voltage-dependent calcium channel subunit alpha-2-4; Voltage-dependent calcium channel subunit delta-4; CACNA2D4
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 0.5 (lot specific)
Specificity
This CACNA2D4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-118 amino acids from the N-terminal region of human CACNA2D4.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
Molecular Weight
127938
Immunogen Sequence Positions
89-118
OMIM
608171
3D Structure
ModBase 3D Structure for Q7Z3S7
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Applications Tested/Suitable for anti-CACNA2D4 antibody
Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS)
Application Notes for anti-CACNA2D4 antibody
WB~~1:1000

Western Blot (WB) of anti-CACNA2D4 antibody

CACNA2D4 Antibody (N-term) western blot analysis in K562 cell line lysates (15ug/lane).This demonstrates the CACNA2D4 antibody detected the CACNA2D4 protein (arrow).
Rabbit Anti-CACNA2D4 Polyclonal Antibody – Cat# MBS9210313

Flow Cytometry (FC/FACS) of anti-CACNA2D4 antibody

CACNA2D4 Antibody (N-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CACNA2D4 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS9210313

Product References and Citations for anti-CACNA2D4 antibody

Wycisk, K.A., et al. Am. J. Hum. Genet. 79(5):973-977(2006)
Qin, N., et al. Mol. Pharmacol. 62(3):485-496(2002)

Other Notes

Small volumes of anti-CACNA2D4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CACNA2D4 purchase

MBS9210313 is an antibody targeting CACNA2D4. Also known as CACNA2D4 Antibody (N-term). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CACNA2D4. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
voltage-dependent calcium channel subunit alpha-2/delta-4
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, alpha 2/delta subunit 4
NCBI Official Symbol
CACNA2D4
NCBI Official Synonym Symbols
RCD4
UniProt Protein Name
Voltage-dependent calcium channel subunit alpha-2/delta-4
UniProt Synonym Protein Names
Voltage-gated calcium channel subunit alpha-2/delta-4
UniProt Gene Name
CACNA2D4
UniProt Entry Name
CA2D4_HUMAN
NCBI Protein Information
voltage-dependent calcium channel subunit alpha-2/delta-4

NCBI Summary for CACNA2D4

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for CACNA2D4

CACNA2D4: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Defects in CACNA2D4 are the cause of retinal cone dystrophy 4 (RCD4). RCD4 is characterized by minimal symptoms except for slowly progressive reduction in visual acuity. Belongs to the calcium channel subunit alpha-2/delta family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13.33

Cellular Component: voltage-gated calcium channel complex

Molecular Function: voltage-gated calcium channel activity; metal ion binding

Biological Process: detection of light stimulus involved in visual perception

Disease: Retinal Cone Dystrophy 4
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-CACNA2D4 antibody

Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000