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CACNB3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6371866

MaxLight490 is a new Blue-Green photostable dye conjugate comparable to DyLight488, Alexa Fluor488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. More details

$1165 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CACNB3, Polyclonal Antibody
Full Product Name
CACNB3 (Voltage-dependent L-type Calcium Channel Subunit beta-3, CAB3, Calcium Channel Voltage-dependent Subunit beta 3, CACNLB3) (MaxLight 490)
Product Gene Name
anti-CACNB3 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human CACNB3.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
50,015 Da
OMIM
601958
3D Structure
ModBase 3D Structure for P54284
Immunogen
Full length human CACNB3, aa1-484 (NP_000716.2).
Immunogen Sequence
MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRLESIRLKQEQKARRSGNPSSLSDIGNRRSPPPSLAKQKQKQAEHVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIERSSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVLQRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRATHHPAPGPGLLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDEASESSRQAWTGSSQRSSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHNHSDRNWQRNRPWPKDSY
Conjugate
MaxLight490
Note
Preservative Free

Product Categories/Family for anti-CACNB3 antibody

Antibodies; Ion Channel
Applications Tested/Suitable for anti-CACNB3 antibody
Western Blot (WB)
Application Notes for anti-CACNB3 antibody
Applications are based on unconjugated antibody.

Other Notes

Small volumes of anti-CACNB3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CACNB3 purchase

MBS6371866 is an antibody targeting CACNB3. Also known as CACNB3 (Voltage-dependent L-type Calcium Channel Subunit beta-3, CAB3, Calcium Channel Voltage-dependent Subunit beta 3, CACNLB3) (MaxLight 490). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CACNB3. It may not necessarily be applicable to this product.

NCBI GI #
40316928
NCBI GeneID
784
NCBI Accession #
NP_000716.2
UniProt Primary Accession #
P54284
UniProt Secondary Accession #
Q13913; A8K0Z4; B7Z4Q1; B7Z973; B7ZAK8; F5GZW7; F5H2P6; F8VSG3
UniProt Related Accession #
P54284
GenBank Nucleotide #
NM_000725
NCBI Official Full Name
voltage-dependent L-type calcium channel subunit beta-3 isoform 1
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, beta 3 subunit
NCBI Official Symbol
CACNB3
NCBI Official Synonym Symbols
CAB3; CACNLB3
UniProt Protein Name
Voltage-dependent L-type calcium channel subunit beta-3
UniProt Synonym Protein Names
Calcium channel voltage-dependent subunit beta 3
Protein Family
Voltage-dependent L-type calcium channel
UniProt Gene Name
CACNB3
UniProt Synonym Gene Names
CACNLB3; CAB3
UniProt Entry Name
CACB3_HUMAN
NCBI Protein Information
voltage-dependent L-type calcium channel subunit beta-3

NCBI Summary for CACNB3

This gene encodes a regulatory beta subunit of the voltage-dependent calcium channel. Beta subunits are composed of five domains, which contribute to the regulation of surface expression and gating of calcium channels and may also play a role in the regulation of transcription factors and calcium transport. [provided by RefSeq, Oct 2011]
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UniProt Comments for CACNB3

CACNB3: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Belongs to the calcium channel beta subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium

Chromosomal Location of Human Ortholog: 12q13

Cellular Component: membrane; apical plasma membrane; voltage-gated calcium channel complex; cytosol

Molecular Function: voltage-gated calcium channel activity; high voltage-gated calcium channel activity; protein kinase binding

Biological Process: membrane depolarization; axon guidance; synaptic transmission; transport; calcium ion transport; T cell receptor signaling pathway; neuromuscular junction development
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Research Articles on CACNB3

1. in the presence of Pax6(S), beta(3) is translocated from the cytoplasm to the nucleus;full-length Ca(v)beta may act directly as a transcription regulator independent of its role in regulating Ca(2+) channel activity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CACNB3 antibody

 Reference Product  PubMed Publications
 CACNA1B antibody  >3 publications with CACNB3 and CACNA1B
 CACNA1F antibody  >1 publications with CACNB3 and CACNA1F

Pathways associated with anti-CACNB3 antibody

 Products by Pathway  Pathway Diagram
 Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway antibodies  Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram

Diseases associated with anti-CACNB3 antibody

 Disease Name  Pubmed Publications
 Atrophy Antibodies  >2 publications with CACNB3 and Atrophy
 Nervous System Malformations Antibodies  >1 publications with CACNB3 and Nervous System Malformations
 Lung Neoplasms Antibodies  >1 publications with CACNB3 and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >1 publications with CACNB3 and Cardiovascular Diseases
 Learning Disorders Antibodies  >1 publications with CACNB3 and Learning Disorders
 Neoplasms, Experimental Antibodies  >1 publications with CACNB3 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >1 publications with CACNB3 and Disease Models, Animal
 Memory Disorders Antibodies  >1 publications with CACNB3 and Memory Disorders
 Hyperplasia Antibodies  >1 publications with CACNB3 and Hyperplasia

Organs/Tissues associated with anti-CACNB3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with CACNB3 and Brain
 Blood Antibodies  >6 publications with CACNB3 and Blood
 Muscle Antibodies  >4 publications with CACNB3 and Muscle
 Nerve Antibodies  >3 publications with CACNB3 and Nerve
 Kidney Antibodies  >2 publications with CACNB3 and Kidney
 Heart Antibodies  >2 publications with CACNB3 and Heart
 Placenta Antibodies  >1 publications with CACNB3 and Placenta
 Pancreas Antibodies  >1 publications with CACNB3 and Pancreas
 Lung Antibodies  >1 publications with CACNB3 and Lung
 Eye Antibodies  >1 publications with CACNB3 and Eye
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