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CACNG3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6280391

The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the… More details

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Product Overview

Online Datasheet in PDF
Product Name
CACNG3, Polyclonal Antibody
Full Product Name
CACNG3, NT (CACNG3, Voltage-dependent calcium channel gamma-3 subunit, Neuronal voltage-gated calcium channel gamma-3 subunit, Transmembrane AMPAR regulatory protein gamma-3) (MaxLight 405)
Product Gene Name
anti-CACNG3 antibody
Product Synonym Names
CACNG3; Voltage-dependent calcium channel gamma-3 subunit; Neuronal voltage-gated calcium channel gamma-3 subunit; Transmembrane AMPAR regulatory protein gamma-3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
35,549 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (24266874..24373737). Location: 16p12.1
OMIM
606403
3D Structure
ModBase 3D Structure for O60359
Immunogen
CACNG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-56 amino acids from the N-terminal region of human CACNG3.
Conjugate
MaxLight405
Note
Preservative Free

Product Categories/Family for anti-CACNG3 antibody

Antibodies; Transmembrane Proteins
Applications Tested/Suitable for anti-CACNG3 antibody
Western Blot (WB), FLISA
Application Notes for anti-CACNG3 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-CACNG3 antibody

Kato, A.S., et al. Trends Neurosci. 33(5):241-248(2010). Sager, C., et al. Neuroscience 158(1):45-54(2009). Everett, K.V., et al. Eur. J. Hum. Genet. 15(4):463-472(2007). Lamesch, P., et al. Genomics 89(3):307-315(2007). Chen, R.S., et al. Cell Biochem. Biophys. 47(2):178-186(2007).

Other Notes

Small volumes of anti-CACNG3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CACNG3 purchase

MBS6280391 is an antibody targeting CACNG3. Also known as CACNG3, NT (CACNG3, Voltage-dependent calcium channel gamma-3 subunit, Neuronal voltage-gated calcium channel gamma-3 subunit, Transmembrane AMPAR regulatory protein gamma-3) (MaxLight 405). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CACNG3. It may not necessarily be applicable to this product.

NCBI GI #
5729756
NCBI GeneID
10368
NCBI Accession #
NP_006530.1
UniProt Primary Accession #
O60359
UniProt Related Accession #
O60359
GenBank Nucleotide #
NM_006539.3
NCBI Official Full Name
voltage-dependent calcium channel gamma-3 subunit
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, gamma subunit 3
NCBI Official Symbol
CACNG3
UniProt Protein Name
Voltage-dependent calcium channel gamma-3 subunit
UniProt Synonym Protein Names
Neuronal voltage-gated calcium channel gamma-3 subunit; Transmembrane AMPAR regulatory protein gamma-3
Protein Family
Voltage-dependent calcium channel
UniProt Gene Name
CACNG3
UniProt Synonym Gene Names
TARP gamma-3
UniProt Entry Name
CCG3_HUMAN
NCBI Protein Information
voltage-dependent calcium channel gamma-3 subunit; TARP gamma-3; voltage-gated calcium channel gamma subunit; transmembrane AMPAR regulatory protein gamma-3; neuronal voltage-gated calcium channel gamma-3 subunit

UniProt Comments for CACNG3

Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state

By similarity.

Subunit structure: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG4, CACNG5, CACNG7 and CACNG8

By similarity.

Subcellular location: Membrane; Multi-pass membrane protein.

Sequence similarities: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
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Research Articles on CACNG3

1. These results suggest that CACNG3 is the best candidate for an age-related macular degeneration risk gene within the 16p12 linkage peak.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CACNG3 antibody

 Reference Product  PubMed Publications
 CACNG4 antibody  >2 publications with CACNG3 and CACNG4
 CACNG1 antibody  >2 publications with CACNG3 and CACNG1
 CACNG7 antibody  >1 publications with CACNG3 and CACNG7
 CACNG6 antibody  >1 publications with CACNG3 and CACNG6

Pathways associated with anti-CACNG3 antibody

 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway antibodies  Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram

Diseases associated with anti-CACNG3 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with CACNG3 and Nervous System Diseases
 Seizures Antibodies  >3 publications with CACNG3 and Seizures
 Brain Diseases Antibodies  >3 publications with CACNG3 and Brain Diseases
 Movement Disorders Antibodies  >1 publications with CACNG3 and Movement Disorders
 Disease Models, Animal Antibodies  >1 publications with CACNG3 and Disease Models, Animal

Organs/Tissues associated with anti-CACNG3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with CACNG3 and Brain
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