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CACNG4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6280400

The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the… More details

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Product Overview

Online Datasheet in PDF
Product Name
CACNG4, Polyclonal Antibody
Full Product Name
CACNG4, ID (CACNG4, Voltage-dependent calcium channel gamma-4 subunit, Neuronal voltage-gated calcium channel gamma-4 subunit, Transmembrane AMPAR regulatory protein gamma-4) (FITC)
Product Gene Name
anti-CACNG4 antibody
Product Synonym Names
CACNG4; Voltage-dependent calcium channel gamma-4 subunit; Neuronal voltage-gated calcium channel gamma-4 subunit; Transmembrane AMPAR regulatory protein gamma-4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
36,579 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (64960980..65029518). Location: 17q24
OMIM
606404
3D Structure
ModBase 3D Structure for Q9UBN1
Immunogen
CACNG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-183 amino acids from the Central region of human CACNG4.
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-CACNG4 antibody

Antibodies; Transmembrane Proteins
Applications Tested/Suitable for anti-CACNG4 antibody
Flow Cytometry (FC/FACS), FLISA, Western Blot (WB)
Application Notes for anti-CACNG4 antibody
FC/FACS: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CACNG4 antibody

CACNG4 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CACNG4 antibody detected the CACNG4 protein (arrow).
Rabbit Anti-CACNG4 Polyclonal Antibody – Cat# MBS6280400

Flow Cytometry (FC/FACS) of anti-CACNG4 antibody

CACNG4 Antibody (Center) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CACNG4 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6280400

Product References and Citations for anti-CACNG4 antibody

Sager, C., et al. Neuroscience 158(1):45-54(2009). Chen, R.S., et al. Cell Biochem. Biophys. 47(2):178-186(2007). Moss, F.J., et al. BMC Neurosci 4, 23 (2003): Chu, P.J., et al. Gene 280 (1-2), 37-48 (2001): Burgess, D.L., et al. Genomics 71(3):339-350(2001).

Other Notes

Small volumes of anti-CACNG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CACNG4 purchase

MBS6280400 is an antibody targeting CACNG4. Also known as CACNG4, ID (CACNG4, Voltage-dependent calcium channel gamma-4 subunit, Neuronal voltage-gated calcium channel gamma-4 subunit, Transmembrane AMPAR regulatory protein gamma-4) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CACNG4. It may not necessarily be applicable to this product.

NCBI GI #
7656948
NCBI GeneID
27092
NCBI Accession #
NP_055220.1
UniProt Primary Accession #
Q9UBN1
UniProt Secondary Accession #
B2RCK0
UniProt Related Accession #
Q9UBN1
GenBank Nucleotide #
NM_014405.3
NCBI Official Full Name
voltage-dependent calcium channel gamma-4 subunit
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, gamma subunit 4
NCBI Official Symbol
CACNG4
UniProt Protein Name
Voltage-dependent calcium channel gamma-4 subunit
UniProt Synonym Protein Names
Neuronal voltage-gated calcium channel gamma-4 subunit; Transmembrane AMPAR regulatory protein gamma-4
Protein Family
Voltage-dependent calcium channel
UniProt Gene Name
CACNG4
UniProt Synonym Gene Names
TARP gamma-4
UniProt Entry Name
CCG4_HUMAN
NCBI Protein Information
voltage-dependent calcium channel gamma-4 subunit; TARP gamma-4; transmembrane AMPAR regulatory protein gamma-4; neuronal voltage-gated calcium channel gamma-4 subunit

UniProt Comments for CACNG4

Function: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Ref.6

Subunit structure: The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG5, CACNG7 and CACNG8

By similarity.

Subcellular location: Cell membrane; Multi-pass membrane protein

By similarity.

Sequence similarities: Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
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Research Articles on CACNG4

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CACNG4 antibody

 Reference Product  PubMed Publications
 CACNG2 antibody  >4 publications with CACNG4 and CACNG2
 CACNG3 antibody  >2 publications with CACNG4 and CACNG3
 CACNG8 antibody  >1 publications with CACNG4 and CACNG8

Pathways associated with anti-CACNG4 antibody

 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway antibodies  Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway antibodies  Glutamate Binding, Activation Of AMPA Receptors And Synaptic Plasticity Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram

Diseases associated with anti-CACNG4 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with CACNG4 and Neoplasms
 Seizures Antibodies  >1 publications with CACNG4 and Seizures
 Nervous System Diseases Antibodies  >1 publications with CACNG4 and Nervous System Diseases
 Breast Neoplasms Antibodies  >1 publications with CACNG4 and Breast Neoplasms

Organs/Tissues associated with anti-CACNG4 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with CACNG4 and Brain
 Muscle Antibodies  >3 publications with CACNG4 and Muscle
 Nerve Antibodies  >1 publications with CACNG4 and Nerve
 Kidney Antibodies  >1 publications with CACNG4 and Kidney
 Embryonic Tissue Antibodies  >1 publications with CACNG4 and Embryonic Tissue
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