CAF-1 Antibody – Rabbit Polyclonal

The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The encoded protein downregulates the innate immune response and therefore provides a therapeutic target for enhancing its antimicrobial activity against foreign agents. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Apr 2016]

CNOT7: Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression. Belongs to the CAF1 family.

Protein type: EC 3.1.13.4; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 8p22-p21.3

Cellular Component: membrane; cytosol; nucleus; CCR4-NOT complex

Molecular Function: signal transducer activity; protein binding; 3'-5'-exoribonuclease activity; poly(A)-specific ribonuclease activity; exoribonuclease activity; RNA binding; metal ion binding; transcription factor activity

Biological Process: deadenylation-dependent decapping; transcription, DNA-dependent; signal transduction; miRNA-mediated gene silencing; regulation of translation; negative regulation of cell proliferation; poly(A) tail shortening; positive regulation of cell proliferation; carbohydrate metabolic process; RNA-mediated gene silencing; positive regulation of transcription from RNA polymerase II promoter; gene expression; cytoplasmic mRNA processing body assembly; mRNA catabolic process, deadenylation-dependent decay