• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CALCRL Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2527891

Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein. The protein encoded by the CALCRL gene is a G protein-coupled receptor related to the calcitonin receptor. CALCRL is linked to one of three… More details

$160 / 0.02 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CALCRL, Polyclonal Antibody
Full Product Name
CALCRL Polyclonal Antibody
Product Gene Name
anti-CALCRL antibody
Product Synonym Names
CRLR; CGRPR
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity purification
Preparation and Storage
Store at -20°C. Avoid freeze / thaw cycles.
OMIM
114190
Immunogen
Synthetic peptide of human CALCRL
Calculated MW
53kDa
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CALCRL antibody
WB, IHC, ELISA
Application Notes for anti-CALCRL antibody
WB: 1:500-1:2000
IHC: 1:50-1:200

Western Blot (WB) of anti-CALCRL antibody

Western Blot analysis of Human lung cancer tissue using CALCRL Polyclonal Antibody at dilution of 1:550
Rabbit Anti-CALCRL Polyclonal Antibody – Cat# MBS2527891

Immunohistochemistry (IHC) of anti-CALCRL antibody

Immunohistochemistry of paraffin-embedded Rat liver using CALCRL Polyclonal Antibody at dilution of 1:50
Rabbit Anti-CALCRL Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2527891

Immunohistochemistry (IHC) of anti-CALCRL antibody

Immunohistochemistry of paraffin-embedded Human brain using CALCRL Polyclonal Antibody at dilution of 1:40
Rabbit Anti-CALCRL Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2527891

Other Notes

Small volumes of anti-CALCRL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CALCRL purchase

MBS2527891 is an antibody targeting CALCRL. Also known as CALCRL Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CALCRL. It may not necessarily be applicable to this product.

NCBI GI #
414144894
NCBI GeneID
10203
NCBI Accession #
NP_005786
UniProt Secondary Accession #
Q53S02; Q53TS5; A8K6G5; A8KAD3
UniProt Related Accession #
Q16602
GenBank Nucleotide #
NM_001271751.1
NCBI Official Full Name
calcitonin gene-related peptide type 1 receptor
NCBI Official Synonym Full Names
calcitonin receptor-like
NCBI Official Symbol
CALCRL
NCBI Official Synonym Symbols
CRLR; CGRPR
UniProt Protein Name
Calcitonin gene-related peptide type 1 receptor
UniProt Synonym Protein Names
Calcitonin receptor-like receptor
Protein Family
Calcitonin gene-related peptide type 1 receptor
UniProt Gene Name
CALCRL
UniProt Synonym Gene Names
CGRPR; CGRP type 1 receptor
UniProt Entry Name
CALRL_HUMAN
NCBI Protein Information
calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; calcitonin receptor-like receptor

UniProt Comments for CALCRL

CALCRL: Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3. Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family.

Protein type: GPCR, family 2; Membrane protein, multi-pass; Receptor, GPCR; Cell cycle regulation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q32.1

Cellular Component: lysosome; endoplasmic reticulum; integral to plasma membrane; plasma membrane; endosome

Molecular Function: G-protein coupled receptor activity; protein binding; calcitonin gene-related polypeptide receptor activity; adrenomedullin receptor activity; protein transporter activity; calcitonin receptor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; protein transport; regulation of muscle contraction; positive regulation of smooth muscle cell proliferation; receptor internalization; calcium ion transport; negative regulation of inflammatory response; heart development; positive regulation of cAMP biosynthetic process; cAMP biosynthetic process; angiogenesis; G-protein signaling, adenylate cyclase activating pathway
Show more

Research Articles on CALCRL

1. the AM system is widely expressed in human thymus from newborns; both AM1 receptor components CLR and RAMP2, but not RAMP3, are not associated with the plasma membrane of TECs and thymocytes but are located intracellularly, notably in the nucleus

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CALCRL antibody

 Reference Product  PubMed Publications
 RAMP2 antibody  >117 publications with CALCRL and RAMP2
 RAMP1 antibody  >106 publications with CALCRL and RAMP1
 RAMP3 antibody  >71 publications with CALCRL and RAMP3
 ADM antibody  >46 publications with CALCRL and ADM
 ADM2 antibody  >9 publications with CALCRL and ADM2
 CRCP antibody  >6 publications with CALCRL and CRCP
 CALCA antibody  >1 publications with CALCRL and CALCA

Pathways associated with anti-CALCRL antibody

 Products by Pathway  Pathway Diagram
 Calcitonin-like Ligand Receptors Pathway antibodies  Calcitonin-like Ligand Receptors Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Endothelin Pathway antibodies  Endothelin Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram

Diseases associated with anti-CALCRL antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >30 publications with CALCRL and Cardiovascular Diseases
 Hypertension Antibodies  >17 publications with CALCRL and Hypertension
 Heart Diseases Antibodies  >15 publications with CALCRL and Heart Diseases
 Inflammation Antibodies  >11 publications with CALCRL and Inflammation
 Disease Models, Animal Antibodies  >10 publications with CALCRL and Disease Models, Animal
 Hypertrophy Antibodies  >7 publications with CALCRL and Hypertrophy
 Necrosis Antibodies  >7 publications with CALCRL and Necrosis
 Kidney Diseases Antibodies  >6 publications with CALCRL and Kidney Diseases
 Edema Antibodies  >6 publications with CALCRL and Edema
 Fibrosis Antibodies  >4 publications with CALCRL and Fibrosis

Organs/Tissues associated with anti-CALCRL antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >77 publications with CALCRL and Vascular
 Muscle Antibodies  >53 publications with CALCRL and Muscle
 Heart Antibodies  >41 publications with CALCRL and Heart
 Kidney Antibodies  >24 publications with CALCRL and Kidney
 Brain Antibodies  >23 publications with CALCRL and Brain
 Embryonic Tissue Antibodies  >16 publications with CALCRL and Embryonic Tissue
 Lung Antibodies  >14 publications with CALCRL and Lung
 Uterus Antibodies  >12 publications with CALCRL and Uterus
 Placenta Antibodies  >11 publications with CALCRL and Placenta
 Bone Antibodies  >9 publications with CALCRL and Bone
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000