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CAMKK1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6466902

MBS6466902 is an antibody targeting CAMKK1. Also known as CAMKK1, NT (Calcium/Calmodulin-dependent Protein Kinase Kinase 1, CaM-kinase Kinase 1, CaM-KK 1, CaMKK 1, CaMKK 1, Calcium/Calmodulin-dependent Protein Kinase Kinase alpha, CaM-kinase Kinase alpha,… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CAMKK1, Polyclonal Antibody
Full Product Name
CAMKK1, NT (Calcium/Calmodulin-dependent Protein Kinase Kinase 1, CaM-kinase Kinase 1, CaM-KK 1, CaMKK 1, CaMKK 1, Calcium/Calmodulin-dependent Protein Kinase Kinase alpha, CaM-kinase Kinase alpha, CaM-KK alpha, CaMKK alpha, CaM-kinase IV Kinase, CAMKKA)
Product Gene Name
anti-CAMKK1 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human CAMKK1.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer.
Molecular Weight
55.735
OMIM
611411
3D Structure
ModBase 3D Structure for Q8N5S9
Immunogen
Synthetic peptide selected from the N-terminal region of human CAMKK1 (KLH).
Conjugate
FITC
Note
Preservative Free

Product Categories/Family for anti-CAMKK1 antibody

Antibodies; Calmodulin
Applications Tested/Suitable for anti-CAMKK1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CAMKK1 antibody
WB: 1:50-1:100
ELISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CAMKK1 antibody

Western blot analysis of anti-CAMKK1 Antibody (N-term) in mouse cerebellum tissue lysates (35ug/lane). CAMKK1 (arrow) was detected using the purified Pab.
Rabbit Anti-CAMKK1 Polyclonal Antibody – Cat# MBS6466902

Western Blot (WB) of anti-CAMKK1 antibody

Western blot analysis of CAMKK1 (arrow) using rabbit polyclonal CAMKK1 Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CAMKK1 gene (Lane 2).
Rabbit Anti-CAMKK1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6466902

Product References and Citations for anti-CAMKK1 antibody

1. Guest, C.B., PLoS ONE 3(2), E1606 (2008). 2. Rudd, M.F., Genome Res. 16(6), 693-701 (2006). 3. Ishikawa, Y., FEBS Lett. 550(1-3), 57-63 (2003). 4. Matsushita, M., J. Biol. Chem. 274(15), 10086-10093 (1999).

Other Notes

Small volumes of anti-CAMKK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CAMKK1. It may not necessarily be applicable to this product.

NCBI GI #
14150045
NCBI GeneID
84254
NCBI Accession #
NP_115670
UniProt Primary Accession #
Q8N5S9
UniProt Related Accession #
Q8N5S9
GenBank Nucleotide #
NP_115670.1
NCBI Official Full Name
calcium/calmodulin-dependent protein kinase kinase 1 isoform a
NCBI Official Synonym Full Names
calcium/calmodulin dependent protein kinase kinase 1
NCBI Official Symbol
CAMKK1
NCBI Official Synonym Symbols
CAMKKA
UniProt Protein Name
Calcium/calmodulin-dependent protein kinase kinase 1
UniProt Synonym Protein Names
CaM-kinase IV kinase; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha
Protein Family
Calcium/calmodulin-dependent protein kinase
UniProt Gene Name
CAMKK1
UniProt Synonym Gene Names
CAMKKA; CaM-KK 1; CaM-kinase kinase 1; CaMKK 1; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha
UniProt Entry Name
KKCC1_HUMAN
NCBI Protein Information
calcium/calmodulin-dependent protein kinase kinase 1

NCBI Summary for CAMKK1

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for CAMKK1

CAMKK1: a calcium/calmodulin-dependent S/T protein kinase of the CAMKK family. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. 2 isoforms of the human protein are produced by alternative splicing. The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition. Binding of calmodulin may releave intrasteric autoinhibition. May be regulated through phosphorylation by CAMK1 and CAMK4. Appears to be autophosphorylated in a Ca2+/calmodulin-dependent manner. Phosphorylation of Ser-458 is blocked upon binding to Ca2+/calmodulin.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Kinase, protein; EC 2.7.11.17; Other group; CAMKK family; Meta subfamily

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: nucleus; cytosol

Molecular Function: calmodulin binding; protein binding; calmodulin-dependent protein kinase activity; ATP binding

Biological Process: synaptic transmission; protein amino acid phosphorylation
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Research Articles on CAMKK1

1. Site-directed mutagenesis analysis revealed that Leu(358) in CaMKKbeta/Ile(322) in CaMKKalpha confer, at least in part, a distinct recognition of AMPK but not of CaMKIalpha.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CAMKK1 antibody

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 CREB Phosphorylation Through The Activation Of CaMKK Pathway antibodies  CREB Phosphorylation Through The Activation Of CaMKK Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram

Diseases associated with anti-CAMKK1 antibody

 Disease Name  Pubmed Publications
 Memory Disorders Antibodies  >1 publications with CAMKK1 and Memory Disorders
 Inflammation Antibodies  >1 publications with CAMKK1 and Inflammation
 Neurobehavioral Manifestations Antibodies  >1 publications with CAMKK1 and Neurobehavioral Manifestations
 Nervous System Diseases Antibodies  >1 publications with CAMKK1 and Nervous System Diseases

Organs/Tissues associated with anti-CAMKK1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with CAMKK1 and Brain
 Lung Antibodies  >4 publications with CAMKK1 and Lung
 Muscle Antibodies  >3 publications with CAMKK1 and Muscle
 Nerve Antibodies  >2 publications with CAMKK1 and Nerve
 Embryonic Tissue Antibodies  >1 publications with CAMKK1 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with CAMKK1 and Pancreas
 Heart Antibodies  >1 publications with CAMKK1 and Heart
 Ovary Antibodies  >1 publications with CAMKK1 and Ovary
 Bone Antibodies  >1 publications with CAMKK1 and Bone
 Kidney Antibodies  >1 publications with CAMKK1 and Kidney
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