• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CASP6 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6280938

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo… More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CASP6, Polyclonal Antibody
Full Product Name
CASP6, NT (CASP6, MCH2, Caspase-6, Apoptotic protease Mch-2, Caspase-6 subunit p18, Caspase-6 subunit p11) (Biotin)
Product Gene Name
anti-CASP6 antibody
Product Synonym Names
CASP6; MCH2; Caspase-6; Apoptotic protease Mch-2; Caspase-6 subunit p18; Caspase-6 subunit p11
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
22,574 Da
OMIM
601532
3D Structure
ModBase 3D Structure for P55212
Immunogen
CASP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human CASP6.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-CASP6 antibody

Antibodies; Apoptosis; Caspase
Applications Tested/Suitable for anti-CASP6 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-CASP6 antibody
IHC: 1:10-50
ELISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CASP6 antibody

Western blot analysis of CASP6 (arrow) using rabbit polyclonal CASP6 Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CASP6 gene.
Rabbit Anti-CASP6 Polyclonal Antibody – Cat# MBS6280938

Immunohistochemistry (IHC) of anti-CASP6 antibody

CASP6 Antibody (N-term) (AP13835a)immunohistochemistry analysis in formalin fixed and paraffin embedded human bladder carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of CASP6 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CASP6 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6280938

Product References and Citations for anti-CASP6 antibody

Wurstle, M.L., et al. J. Biol. Chem. 285(43):33209-33218(2010). Lee, S.Y., et al. J Thorac Oncol 5(8):1152-1158(2010). Halawani, D., et al. J. Neurosci. 30(17):6132-6142(2010). Kim, M.S., et al. APMIS 118(4):308-312(2010). Yoo, N.J., et al. Tumori 96(1):138-142(2010).

Other Notes

Small volumes of anti-CASP6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CASP6 purchase

MBS6280938 is an antibody targeting CASP6. Also known as CASP6, NT (CASP6, MCH2, Caspase-6, Apoptotic protease Mch-2, Caspase-6 subunit p18, Caspase-6 subunit p11) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CASP6. It may not necessarily be applicable to this product.

NCBI GI #
14916485
NCBI GeneID
839
NCBI Accession #
NP_116787.1
NCBI Related Accession #
NP_001217.2
UniProt Primary Accession #
P55212
UniProt Secondary Accession #
Q9BQE7
UniProt Related Accession #
P55212
GenBank Nucleotide #
NM_032992.2
NCBI Official Full Name
caspase-6 isoform beta
NCBI Official Synonym Full Names
caspase 6
NCBI Official Symbol
CASP6
NCBI Official Synonym Symbols
MCH2
UniProt Protein Name
Caspase-6
UniProt Synonym Protein Names
Apoptotic protease Mch-2
Protein Family
Caspase
UniProt Gene Name
CASP6
UniProt Synonym Gene Names
MCH2; CASP-6
UniProt Entry Name
CASP6_HUMAN
NCBI Protein Information
caspase-6

NCBI Summary for CASP6

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]
Show more

UniProt Comments for CASP6

CASP6: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Activation is suppressed by phosphorylation at Ser-257. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.22.59; Protease; Apoptosis

Chromosomal Location of Human Ortholog: 4q25

Cellular Component: nucleoplasm; cytoplasm; cytosol

Molecular Function: identical protein binding; protein binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity

Biological Process: epithelial cell differentiation; apoptosis; proteolysis; cell structure disassembly during apoptosis
Show more

Research Articles on CASP6

1. The prodomain region was found to be intrinsically disordered independent of the activation state of caspase-6; however, its complete removal resulted in the protection of the adjacent 26-32 region, suggesting that this region may play a regulatory role. The molecular details of caspase-6 dynamics in solution provide a comprehensive scaffold for strategic design of therapeutic approaches for neurodegenerative disorders.
Show more

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CASP6 antibody

 Reference Product  PubMed Publications
 CASP3 antibody  >402 publications with CASP6 and CASP3
 CASP8 antibody  >176 publications with CASP6 and CASP8
 APP antibody  >9 publications with CASP6 and APP
 SATB1 antibody  >5 publications with CASP6 and SATB1
 TFAP2A antibody  >3 publications with CASP6 and TFAP2A
 LMNA antibody  >3 publications with CASP6 and LMNA
 KRT18 antibody  >1 publications with CASP6 and KRT18

Pathways associated with anti-CASP6 antibody

 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Apoptosis Modulation By HSP70 Pathway antibodies  Apoptosis Modulation By HSP70 Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Breakdown Of The Nuclear Lamina Pathway antibodies  Breakdown Of The Nuclear Lamina Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram

Diseases associated with anti-CASP6 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >179 publications with CASP6 and Neoplasms
 Necrosis Antibodies  >77 publications with CASP6 and Necrosis
 Nervous System Diseases Antibodies  >72 publications with CASP6 and Nervous System Diseases
 Drug Toxicity Antibodies  >41 publications with CASP6 and Drug Toxicity
 Disease Models, Animal Antibodies  >34 publications with CASP6 and Disease Models, Animal
 Breast Neoplasms Antibodies  >32 publications with CASP6 and Breast Neoplasms
 Adenocarcinoma Antibodies  >27 publications with CASP6 and Adenocarcinoma
 Inflammation Antibodies  >22 publications with CASP6 and Inflammation
 Nerve Degeneration Antibodies  >20 publications with CASP6 and Nerve Degeneration
 Cognition Disorders Antibodies  >18 publications with CASP6 and Cognition Disorders

Organs/Tissues associated with anti-CASP6 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >74 publications with CASP6 and Blood
 Brain Antibodies  >71 publications with CASP6 and Brain
 Liver Antibodies  >30 publications with CASP6 and Liver
 Lung Antibodies  >26 publications with CASP6 and Lung
 Muscle Antibodies  >21 publications with CASP6 and Muscle
 Skin Antibodies  >21 publications with CASP6 and Skin
 Kidney Antibodies  >21 publications with CASP6 and Kidney
 Prostate Antibodies  >17 publications with CASP6 and Prostate
 Embryonic Tissue Antibodies  >15 publications with CASP6 and Embryonic Tissue
 Eye Antibodies  >14 publications with CASP6 and Eye
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000