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CCL7 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6282084

This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CCL7, Polyclonal Antibody
Full Product Name
CCL7, ID (CCL7, MCP3, SCYA6, SCYA7, C-C motif chemokine 7, Monocyte chemoattractant protein 3, Monocyte chemotactic protein 3, NC28, Small-inducible cytokine A7) (Azide free) (HRP)
Product Gene Name
anti-CCL7 antibody
Product Synonym Names
CCL7; MCP3; SCYA6; SCYA7; C-C motif chemokine 7; Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; NC28; Small-inducible cytokine A7
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
11,200 Da
OMIM
158106
3D Structure
ModBase 3D Structure for P80098
Immunogen
Synthetic peptide corresponding to a portion within aa25-54 from the central region of human CCL7 conjugated to KLH (NP_006246.2).
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-CCL7 antibody

Antibodies; Growth Factors; Cytokines
Applications Tested/Suitable for anti-CCL7 antibody
Western Blot (WB)
Application Notes for anti-CCL7 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CCL7 antibody

CCL7 Antibody (Center) MBS6001451 western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the CCL7 antibody detected the CCL7 protein (arrow).
Rabbit Anti-CCL7 Polyclonal Antibody – Cat# MBS6282084

Product References and Citations for anti-CCL7 antibody

McGovern, D.P., et al. Hum. Mol. Genet. 19(17):3468-3476(2010). Han, S., et al. Hum. Immunol. 71(7):727-730(2010). Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010). Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010). Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010).

Other Notes

Small volumes of anti-CCL7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL7 purchase

MBS6282084 is an antibody targeting CCL7. Also known as CCL7, ID (CCL7, MCP3, SCYA6, SCYA7, C-C motif chemokine 7, Monocyte chemoattractant protein 3, Monocyte chemotactic protein 3, NC28, Small-inducible cytokine A7) (Azide free) (HRP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL7. It may not necessarily be applicable to this product.

NCBI GI #
13435402
NCBI GeneID
6354
NCBI Accession #
NP_006264.2
UniProt Primary Accession #
P80098
UniProt Secondary Accession #
Q569J6
UniProt Related Accession #
P80098
GenBank Nucleotide #
NM_006273.3
NCBI Official Full Name
C-C motif chemokine 7
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 7
NCBI Official Symbol
CCL7
NCBI Official Synonym Symbols
FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7
UniProt Protein Name
C-C motif chemokine 7
UniProt Synonym Protein Names
Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; MCP-3; NC28; Small-inducible cytokine A7
Protein Family
C-C motif chemokine
UniProt Gene Name
CCL7
UniProt Synonym Gene Names
MCP3; SCYA6; SCYA7; MCP-3
UniProt Entry Name
CCL7_HUMAN
NCBI Protein Information
C-C motif chemokine 7; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; small inducible cytokine A7 (monocyte chemotactic protein 3); small-inducible cytokine A7

UniProt Comments for CCL7

CCL7: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q11.2-q12

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; CCR1 chemokine receptor binding; CCR2 chemokine receptor binding; chemokine activity

Biological Process: cellular calcium ion homeostasis; regulation of cell shape; monocyte chemotaxis; cell-cell signaling; eosinophil chemotaxis; response to gamma radiation; cytoskeleton organization and biogenesis; immune response; inflammatory response; chemotaxis; signal transduction; positive regulation of cell migration
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Research Articles on CCL7

1. Overexpression of ISL1 in human mesnchymal stem cells promotes angiogenesis in vitro and in vivo through increasing secretion of MCP3 and other paracrine factors.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCL7 antibody

 Reference Product  PubMed Publications
 CCL2 antibody  >260 publications with CCL7 and CCL2
 CCL5 antibody  >124 publications with CCL7 and CCL5
 CCR2 antibody  >92 publications with CCL7 and CCR2
 CCL11 antibody  >71 publications with CCL7 and CCL11
 CCR1 antibody  >44 publications with CCL7 and CCR1
 CCR3 antibody  >43 publications with CCL7 and CCR3
 CCR5 antibody  >37 publications with CCL7 and CCR5
 CCL17 antibody  >24 publications with CCL7 and CCL17
 CXCR3 antibody  >10 publications with CCL7 and CXCR3
 CCR10 antibody  >3 publications with CCL7 and CCR10

Pathways associated with anti-CCL7 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram

Diseases associated with anti-CCL7 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >190 publications with CCL7 and Inflammation
 Respiratory Tract Diseases Antibodies  >65 publications with CCL7 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >57 publications with CCL7 and Lung Diseases
 Necrosis Antibodies  >52 publications with CCL7 and Necrosis
 Hypersensitivity Antibodies  >52 publications with CCL7 and Hypersensitivity
 Disease Models, Animal Antibodies  >48 publications with CCL7 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >25 publications with CCL7 and Cardiovascular Diseases
 Fibrosis Antibodies  >23 publications with CCL7 and Fibrosis
 Heart Diseases Antibodies  >12 publications with CCL7 and Heart Diseases
 Carcinoma Antibodies  >10 publications with CCL7 and Carcinoma

Organs/Tissues associated with anti-CCL7 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >280 publications with CCL7 and Blood
 Lung Antibodies  >70 publications with CCL7 and Lung
 Skin Antibodies  >34 publications with CCL7 and Skin
 Intestine Antibodies  >14 publications with CCL7 and Intestine
 Uterus Antibodies  >10 publications with CCL7 and Uterus
 Placenta Antibodies  >4 publications with CCL7 and Placenta
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