• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CCNA2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6471156

MBS6471156 is an antibody targeting CCNA2. Also known as CCNA2, CT (Cyclin-A2, Cyclin-A, CCN1, CCNA) (HRP). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCNA2, Polyclonal Antibody
Full Product Name
CCNA2, CT (Cyclin-A2, Cyclin-A, CCN1, CCNA) (HRP)
Product Gene Name
anti-CCNA2 antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Ammonium Sulfate Precipitation.
Specificity
Recognizes human CCNA2.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates.
Molecular Weight
51.1 kDa (456aa)
OMIM
123835
3D Structure
ModBase 3D Structure for P20248
Immunogen
Synthetic peptide selected from the C-terminal region of human CCNA2 (KLH).
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-CCNA2 antibody

Antibodies; Cyclin
Applications Tested/Suitable for anti-CCNA2 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-CCNA2 antibody
IHC: 1:10-1:50
ELISA: 1:1,000
WB: 1:100-1:500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CCNA2 antibody

Western blot analysis of CCNA2 (arrow) using rabbit polyclonal CCNA2 Antibody (C-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CCNA2 gene (Lane 2) (Origene Technologies).
Rabbit Anti-CCNA2 Polyclonal Antibody – Cat# MBS6471156

Immunohistochemistry (IHC) of anti-CCNA2 antibody

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CCNA2 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-CCNA2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6471156

Product References and Citations for anti-CCNA2 antibody

1. Henglein B., Proc. Natl. Acad. Sci. USA 91:5490-5494(1994). 2. Wang J., Nature 343:555-557(1990). 3. Tsang, W.Y., J. Cell Biol. 178(4), 621-633 (2007).

Other Notes

Small volumes of anti-CCNA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CCNA2. It may not necessarily be applicable to this product.

NCBI GI #
4502613
NCBI GeneID
890
NCBI Accession #
NP_001228
UniProt Primary Accession #
P20248
UniProt Secondary Accession #
Q2M3U6; Q4W5P4; Q6LER8; A8K7B6
UniProt Related Accession #
P20248
GenBank Nucleotide #
NM_001237.4
NCBI Official Full Name
cyclin-A2
NCBI Official Synonym Full Names
cyclin A2
NCBI Official Symbol
CCNA2
NCBI Official Synonym Symbols
CCN1; CCNA
UniProt Protein Name
Cyclin-A2
Protein Family
Cyclin
UniProt Gene Name
CCNA2
UniProt Synonym Gene Names
CCN1; CCNA; Cyclin-A
UniProt Entry Name
CCNA2_HUMAN
NCBI Protein Information
cyclin-A2

NCBI Summary for CCNA2

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016]

UniProt Comments for CCNA2

CCNA2: a member of the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions.

Protein type: Cell cycle regulation; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 4q27

Cellular Component: nucleoplasm; male pronucleus; cytoplasm; female pronucleus; nucleus

Molecular Function: protein binding; protein kinase binding

Biological Process: mitosis; positive regulation of fibroblast proliferation; organ regeneration; response to glucagon stimulus; cell division; positive regulation of transcription, DNA-dependent; mitotic cell cycle G2/M transition DNA damage checkpoint; regulation of G2/M transition of mitotic cell cycle; Ras protein signal transduction; regulation of cyclin-dependent protein kinase activity; mitotic cell cycle; G2/M transition of mitotic cell cycle; response to estradiol stimulus
Show more

Research Articles on CCNA2

1. Findings suggest that ERK1/2-mediated Cdk2/cyclin A signaling pathway is involved in 7-hydroxy-5,4'-dimethoxy-2-arylbenzofuran (Ary) - induced G1/S-phase arrest.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCNA2 antibody

 Reference Product  PubMed Publications
 CDK2 antibody  >87 publications with CCNA2 and CDK2
 CDK1 antibody  >55 publications with CCNA2 and CDK1
 CDKN1A antibody  >53 publications with CCNA2 and CDKN1A
 CDK4 antibody  >33 publications with CCNA2 and CDK4
 CDKN1B antibody  >31 publications with CCNA2 and CDKN1B
 E2F1 antibody  >17 publications with CCNA2 and E2F1
 CDK6 antibody  >12 publications with CCNA2 and CDK6
 CDC20 antibody  >11 publications with CCNA2 and CDC20
 CDC6 antibody  >5 publications with CCNA2 and CDC6

Pathways associated with anti-CCNA2 antibody

 Products by Pathway  Pathway Diagram
 AMP-activated Protein Kinase (AMPK) Signaling Pathway antibodies  AMP-activated Protein Kinase (AMPK) Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway antibodies  APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway antibodies  Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway Diagram
 Cdc20:Phospho-APC/C Mediated Degradation Of Cyclin A Pathway antibodies  Cdc20:Phospho-APC/C Mediated Degradation Of Cyclin A Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram

Diseases associated with anti-CCNA2 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >45 publications with CCNA2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >28 publications with CCNA2 and Adenocarcinoma
 Lung Neoplasms Antibodies  >23 publications with CCNA2 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >23 publications with CCNA2 and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >21 publications with CCNA2 and Disease Models, Animal
 Liver Diseases Antibodies  >21 publications with CCNA2 and Liver Diseases
 Liver Neoplasms Antibodies  >19 publications with CCNA2 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >18 publications with CCNA2 and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >14 publications with CCNA2 and Cardiovascular Diseases
 Prostatic Neoplasms Antibodies  >13 publications with CCNA2 and Prostatic Neoplasms

Organs/Tissues associated with anti-CCNA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >53 publications with CCNA2 and Liver
 Blood Antibodies  >51 publications with CCNA2 and Blood
 Lung Antibodies  >39 publications with CCNA2 and Lung
 Brain Antibodies  >28 publications with CCNA2 and Brain
 Vascular Antibodies  >27 publications with CCNA2 and Vascular
 Muscle Antibodies  >26 publications with CCNA2 and Muscle
 Bone Antibodies  >22 publications with CCNA2 and Bone
 Embryonic Tissue Antibodies  >22 publications with CCNA2 and Embryonic Tissue
 Testis Antibodies  >17 publications with CCNA2 and Testis
 Prostate Antibodies  >16 publications with CCNA2 and Prostate
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000