Rabbit Anti-CD2 Polyclonal Antibody – Cat# MBS8104519

Anti-CD2 rabbit polyclonal antibody at 1:500 dilution
Lane A: Jurkat Membrane Lysate
Lane B: MOLt-4 Membrane Lysate

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.
Performed under reducing conditions.

Predicted band size:39 kDa
Observed band size:52 kDa

CD2 Antibody – Rabbit Polyclonal

Name: CD2 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS8104519
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8104519

T-cell surface antigen CD2, also known as T-cell surface antigen T11/Leu-5, and SRBC, is a single-pass type I membrane protein. It contains one Ig-like C2-type domain and one Ig-like V-type domain. CD2 is a cell adhesion molecule expressed on T cells and is… More details

$370 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD2, Polyclonal Antibody

Full Product Name

Anti-CD2 Antibody, Rabbit Polyclonal

Product Gene Name

anti-CD2 antibody

Product Synonym Names

CD2 Antibody, Rabbit PAb, Antigen Affinity Purified; CD2 molecule; Anti-LFA-2 Antibody; Anti-SRBC Antibody; Anti-T11 Antibody

Clonality

Polyclonal

Isotype

Rabbit IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Liquid; 0.2um filtered solution in PBS

Purity/Purification

Protein A & Antigen Affinity

Specificity

Human CD2

Preparation and Storage

This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Molecular Weight

39,448 Da

OMIM

186990

3D Structure

ModBase 3D Structure for P06729

Immunogen

Recombinant Human CD2 protein

Conjugation

Unconjugated

Preparation

Produced in rabbits immunized with purified, recombinant Human CD2 (rh CD2). CD2 specific IgG was purified by Human CD2 affinity chromatography.

Applications Tested/Suitable for anti-CD2 antibody

Western Blot (WB), ELISA (EIA)

Application Notes for anti-CD2 antibody

WB: 1:500-1:2000
ELISA: 1:1000-1:2000

Product References and Citations for anti-CD2 antibody

Yang JJ, et al. (2001) Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. Curr Protein Pept Sci. 2(1): 1-17.
Wilkins AL, et al. (2003) Structural biology of the cell adhesion protein CD2: from molecular recognition to protein folding and design. Curr Protein Pept Sci. 4(5): 367-73.
McNerney ME, et al. (2006) The CD2 family of natural killer cell receptors. Curr Top Microbiol Immunol. 298: 91-120.

Other Notes

Small volumes of anti-CD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD2 purchase

MBS8104519 is an antibody targeting CD2. Also known as Anti-CD2 Antibody, Rabbit Polyclonal. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD2. It may not necessarily be applicable to this product.

NCBI GI #

156071472

NCBI GeneID

914

NCBI Accession #

NP_001758.2

UniProt Primary Accession #

P06729

UniProt Secondary Accession #

Q96TE5

UniProt Related Accession #

P06729

GenBank Nucleotide #

NM_001767.3

NCBI Official Full Name

T-cell surface antigen CD2

NCBI Official Synonym Full Names

CD2 molecule

NCBI Official Symbol

CD2

NCBI Official Synonym Symbols

T11; SRBC; LFA-2

UniProt Protein Name

T-cell surface antigen CD2

UniProt Synonym Protein Names

Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD_antigen: CD2

Protein Family

T-cell surface antigen

UniProt Gene Name

CD2

UniProt Synonym Gene Names

SRBC

UniProt Entry Name

CD2_HUMAN

NCBI Protein Information

T-cell surface antigen CD2; CD2 antigen (p50), sheep red blood cell receptor; LFA-3 receptor; T-cell surface antigen T11/Leu-5; erythrocyte receptor; lymphocyte-function antigen-2; rosette receptor

NCBI Summary for CD2

CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]

UniProt Comments for CD2

CD2: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function.

Protein type: Cell surface; Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: internal side of plasma membrane; cell surface; anchored to plasma membrane; integral to plasma membrane; plasma membrane; extracellular region; intercellular junction; external side of plasma membrane

Molecular Function: protein binding; protein homodimerization activity; receptor activity; receptor binding

Biological Process: heterotypic cell-cell adhesion; cell-cell adhesion; cell surface receptor linked signal transduction; T cell activation; apoptosis; natural killer cell activation; regulation of T cell differentiation; blood coagulation; lipid raft polarization; positive regulation of tumor necrosis factor production; leukocyte migration; positive regulation of myeloid dendritic cell activation

Research Articles on CD2

1. Although sMCs displayed immunoreactivity for one of the neoplastic antigens in the majority of SM patients, the aberrant CD2 and/or CD25 expression on sMCs is not as indicative of SM as the BMMC immunophenotype.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD2 antibody

Reference Product	PubMed Publications
CD58 antibody	>416 publications with CD2 and CD58
PTPRC antibody	>344 publications with CD2 and PTPRC
CD2AP antibody	>164 publications with CD2 and CD2AP
CD48 antibody	>147 publications with CD2 and CD48
LCK antibody	>79 publications with CD2 and LCK
SH3KBP1 antibody	>19 publications with CD2 and SH3KBP1
CD2BP2 antibody	>13 publications with CD2 and CD2BP2
ITK antibody	>11 publications with CD2 and ITK
CD8A antibody	>3 publications with CD2 and CD8A

Pathways associated with anti-CD2 antibody

Products by Pathway	Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Surface Interactions At The Vascular Wall Pathway antibodies	Cell Surface Interactions At The Vascular Wall Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram

Diseases associated with anti-CD2 antibody

Disease Name	Pubmed Publications
Lymphoma Antibodies	>872 publications with CD2 and Lymphoma
Skin Diseases Antibodies	>328 publications with CD2 and Skin Diseases
Necrosis Antibodies	>317 publications with CD2 and Necrosis
Inflammation Antibodies	>241 publications with CD2 and Inflammation
Kidney Diseases Antibodies	>154 publications with CD2 and Kidney Diseases
Liver Diseases Antibodies	>127 publications with CD2 and Liver Diseases
Skin Neoplasms Antibodies	>126 publications with CD2 and Skin Neoplasms
Lung Diseases Antibodies	>105 publications with CD2 and Lung Diseases
Vascular Diseases Antibodies	>103 publications with CD2 and Vascular Diseases
Fever Antibodies	>101 publications with CD2 and Fever

Organs/Tissues associated with anti-CD2 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>4682 publications with CD2 and Blood
Bone Antibodies	>773 publications with CD2 and Bone
Muscle Antibodies	>543 publications with CD2 and Muscle
Kidney Antibodies	>496 publications with CD2 and Kidney
Thymus Antibodies	>438 publications with CD2 and Thymus
Lymph Node Antibodies	>391 publications with CD2 and Lymph Node
Heart Antibodies	>309 publications with CD2 and Heart
Spleen Antibodies	>280 publications with CD2 and Spleen
Intestine Antibodies	>254 publications with CD2 and Intestine
Lung Antibodies	>187 publications with CD2 and Lung